Correction to “Immobilization Studies of an Engineered Arginine-Tryptophan Rich Peptide on a Silicone Surface with Antimicrobial and Antibiofilm Activity”

Lim, Kaiyang; Chua, Ray Rong Yuan; Saravanan, Rathi; Basu, Anindya; Mishra, Biswajit; Tambyah, Paul Anantharajah; Ho, Bow; Leong, Susanna Su Jan

doi:10.1021/am403162f

Cited by 4 publications

(1 citation statement)

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“…. AMPs are extensively used as antimicrobial agents on surfaces due to the broad spectrum of activity, low toxicity, long-term stability, and high potency. − Currently, there are two main kinds of AMP-based antimicrobial coating surfaces: (a) surfaces with controlled-release AMPs (from AMP reservoir) and (b) substrates with covalently immobilized AMPs . Compared with the release-based system, the covalently immobilized AMP system is more sustainable due to the lower cytotoxicity and long-term stability.…”

Section: Introductionmentioning

confidence: 99%

Interfacial Behaviors of Antimicrobial Peptide Cecropin P1 Immobilized on Different Self-Assembled Monolayers

Wang

Wei

et al. 2015

J. Phys. Chem. C

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Surfaces immobilized with biological molecules such as peptides and proteins are widely used in many important applications including biosensors, medical devices, and food packaging. It was found that the structures of surface-immobilized peptides control their surface properties. In this study, we investigated interfacial behaviors of antimicrobial peptide cecropin P1 (CP1) immobilized onto a maleimide-terminated self-assembled monolayer (Mal SAM) and a mixed SAM (Mal-OH SAM, a mixture of maleimide-terminated SAM and hydroxyl-terminated SAM) surface via C-terminus modified cysteine (CP1c). The surface coverage, secondary structure, orientation, and antimicrobial activity of immobilized CP1c were investigated using surface plasmon resonance (SPR), circular dichroism (CD), sum frequency generation (SFG) vibrational spectroscopy, dynamic contact antimicrobial assay, and coarse grained molecular dynamics (MD) simulations. It was found that the surface coverages of CP1c on the Mal SAM and the mixed Mal-OH SAM are similar. CP1c on Mal SAM possessed a dominant helical structure with a single orientation of ∼32° versus surface normal. CP1c on Mal-OH mixed SAM surface also possessed a dominant helical structure but with multiple orientations. MD simulation results can be correlated to the experimental data: the simulation results indicate a narrow distribution of orientations of CP1c immobilized on Mal SAM, but multiple orientations are sampled on the more hydrophilic Mal-OH SAM. Even though the surface orientations of CP1c immobilized on the two SAM surfaces are different, activity against both Gram-negative and Gram-positive bacteria (Escherichia coli and Staphylococcus aureus) exhibited similar results for CP1c immobilized on both SAM surfaces. We believe that this is because the antimicrobial activity of the surface-immobilized peptides is mainly affected by the electrostatic interactions between the strong basic N-terminal residues and the negatively charged bacteria cell wall/cell membrane.

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Section: Introductionmentioning

confidence: 99%

Interfacial Behaviors of Antimicrobial Peptide Cecropin P1 Immobilized on Different Self-Assembled Monolayers

Wang

Wei

et al. 2015

J. Phys. Chem. C

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Red pepper peptide coatings control Staphylococcus epidermidis adhesion and biofilm formation

Borowski

Barros

Silva

et al. 2020

International Journal of Pharmaceutics

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Controlled Retention of BMP-2-Derived Peptide on Nanofibers Based on Mussel-Inspired Adhesion for Bone Formation

Lee

Perikamana

Ahmad

et al. 2017

Tissue Engineering Part A

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Correction to “Immobilization Studies of an Engineered Arginine-Tryptophan Rich Peptide on a Silicone Surface with Antimicrobial and Antibiofilm Activity”

Cited by 4 publications

References 0 publications

Interfacial Behaviors of Antimicrobial Peptide Cecropin P1 Immobilized on Different Self-Assembled Monolayers

Interfacial Behaviors of Antimicrobial Peptide Cecropin P1 Immobilized on Different Self-Assembled Monolayers

Red pepper peptide coatings control Staphylococcus epidermidis adhesion and biofilm formation

Controlled Retention of BMP-2-Derived Peptide on Nanofibers Based on Mussel-Inspired Adhesion for Bone Formation

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