Correction to “Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins”

Lin, Jia-Le; Wang, Ze-Kun; Xu, Ziyue; Wei, Lei; Zhang, Yunchang; Wang, Hui; Zhang, Dan‐Wei; Zhou, Wei; Zhang, Yue‐Biao; Liu, Yi; Li, Zhan‐Ting

doi:10.1021/jacs.0c04230

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the pioneering research on dynamers by Skene and Lehn [30] , dynamic covalent polymers have been widely used for constructing thermodynamically controlled macromolecular and supramolecular targets [31][32][33][34][35][36][37] . We have recently constructed a kind of water-soluble flexible organic framework (FOF) through quantitative acylhydrazine or disulfide bond formation [38][39][40][41][42][43] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and intracellular basic protein delivery of a polyanionic flexible organic framework

Liu,

Wu,

Guo

et al. 2024

Chem Synth

Self Cite

View full text Add to dashboard Cite

Although cationic porous polymers have been widely used for gene and drug delivery, the delivering function of anionic porous polymers has rarely been explored. Herein, we prepare a polyanionic flexible organic framework (pa-FOF) through the quantitative formation of the acylhydrazone bond from a tetraanionic tetraaldehyde and a tetraanionic diacylhydrazine. Pa-FOF is highly water-soluble and has a size of 26 to 51 nm, which depends on the concentration of the monomers, and an aperture of approximately 3.8 nm. Fluorescence, zeta potential, confocal laser scanning microscopic and flow cytometric experiments reveal that pa-FOF can adsorb basic proteins, including lysozyme, trypsin and cytochrome c, which is driven by intermolecular ion-pairing electrostatic attraction and hydrophobicity, and realizes efficient intracellular delivery of the adsorbed proteins. Confocal laser scanning microscopic imaging experiments further illustrate that the delivery of cytochrome c can significantly increase its ability of causing cell apoptosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and intracellular basic protein delivery of a polyanionic flexible organic framework

Liu,

Wu,

Guo

et al. 2024

Chem Synth

Self Cite

View full text Add to dashboard Cite

show abstract

“…48 Up to now, many robust hydrazone-linked COFs via integrating different hydrazine-and aldehyde-containing building blocks have been prepared and demonstrated applications in moist and water conditions, such as water pollutants removal, proton conduction, energy production/storage, drug delivery, and so on. [49][50][51][52][53][54] However, no hydrazone-linked COF has been characterized using single-crystal X-ray diffraction (SCXRD). In contrast, exploring discrete hydrazone-linked organic cage compounds remains in its initial stage, regardless of their number or applications.…”

Section: Introductionmentioning

confidence: 99%