Correlación de los perfiles lipoproteicos y variables antropométricas con concentraciones séricas de lipoproteína(a) en la infancia

Meabe, Y. Sáez; Bernar, M Lafita; Chivite, JP Sáez de Lafuente; Gofinondo, I. Narváez; Rius, Montserrat; López, AM Magro; Gorostiza, JD Sagastagoitia; Miguel, Enrique Molinero de; Ezkurdia, JA Iriarte

doi:10.1157/13085509

Cited by 3 publications

(5 citation statements)

References 17 publications

(17 reference statements)

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“…Regarding the laboratory parameters, this study showed that patients belonging to the lower tertiles (T1) and to the upper tertiles Lp(a) (T3) did not show significant differences in all conventional lipid profile with respect to the reference category (middle tertile Lp(a)T2)) with (all P > 0.05), the median concentrations of LDL-c were similar between the higher Lp(a) tertile (T3) and the middle Lp(a) tertile (T2) with (2.5 mmol.L -1 (IQR 1.9-3.3) vs. 2.5 mmol.L -1 (IQR 1.9-3.1), P > 0.05), the some finding was reported by several sudies [35][36][37][38], Qayum, et al [36] did not find a significant association between Lp(a) and LDL-c in a cohort of 257 children with high risk cardiovascular. In contrast, Meabe YS, et al [37] found a positive correlation between Lp(a), LDL-c and apo B in a cohort of Spanish children, the same findings were reported by Gannagé-Yared MH, et al [38]. In our data, only AIP was significantly lower in patient with normal Lp(a) (T2) compared to a group with very-low Lp(a) (T1) and elevated Lp(a) (T3).…”

Section: Statements and Declarationsmentioning

confidence: 71%

Association between Lipoprotein (a) Concentration, Glycemic Control and Diabetes Complications in Moroccan Patients with Type 2 Diabetes Mellitus

Aboulmakarim¹,

Latifa²,

Soumia³

et al. 2023

Ann Endocrinol Metab

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Objective:The objective of this prospective study was to investigate the relationship of the levels of Lp(a) in Moroccan patients with type 2 diabetes mellitus (T2DM) with other metabolic factors related to the severity of T2DM.Material and methods: 231 T2DM patients aged over 18-years-old were analyzed. Fasting plasma glucose, lipid profile, liver and renal tests, glycated hemoglobin test (HbA1c), and Lp(a) level were measured. Sociodemographic data, clinical characteristics and anthropometric measures were reported by the patient's endocrinologists. Our results were analyzed using SPSS software. Results:The prevalence of Lp(a) > 75 nmol.L −1 was 31.2% with a median of 105.3 nmol.L −1 (IQR 87.4-154). Compared to the group without hyper lipoprotein (a), hyper lipoprotein (a) patients were more likely to be older (median 61 years [IQR 29-83] vs. 58 years [17-85]; P = 0.014), obese or overweight (21% vs. 2%; P < 0.05 ), have a longer duration of diabetes (11 years (6-19.5) vs. 10 (6-15), P = 0.053), and have a higher prevalence of previous myocardial infarction (22.2% vs. 5%; P < 0.001). In contrast, there were no significant differences in sex ratio, nephropathy, retinopathy, lipid profiles, and glycemic control between the two groups (P > 0.05). The higher Lp(a) tertile (T3) had significantly higher BMI, Waist circumference and overall macrovascular complications P < 0.05. There was a weak positive correlation between Lp(a) with total cholesterol concentration (r = 0.137, P = 0.037), and LDL-c (r = 0.17, P < 0.01). Conclusion:we suggest measuring Lp(a) in routine evaluation in T2DM patients.

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Section: Statements and Declarationsmentioning

confidence: 71%

Association between Lipoprotein (a) Concentration, Glycemic Control and Diabetes Complications in Moroccan Patients with Type 2 Diabetes Mellitus

Aboulmakarim¹,

Latifa²,

Soumia³

et al. 2023

Ann Endocrinol Metab

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“…A positive correlation was observed between Lp(a) and LDL cholesterol (LDL-c) (3,8,9), Lp(a) and total cholesterol (TC) ( 9 , 10 ) and Lp(a) and apolipoprotein B (Apo B) ( 3 , 9 ) , which suggests an association between Lp(a) levels and lipid profile. According to Meabe et al ( 3 ) , the fact that high Lp(a) levels are associated with high LDL-c levels proposes that the LDL metabolism may be involved in the Lp(a) synthesis. In patients with high LDL-c levels, Lp(a) is an important factor to determine atherosclerotic disease, as well as its severity and progression rate ( 15 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Observou-se correlação positiva entre Lp(a) e colesterol LDL (LDL-c) ( 3 , 8 , 9 ) , Lp(a) e colesterol total (CT) ( 9 , 10 ) e Lp(a) e apolipoproteína B (Apo B) ( 3 , 9 ) , o que sugere uma associação entre concentrações de Lp(a) e perfil lipídico. Segundo Meabe et al ( 3 ) , o fato de níveis elevados de Lp(a) se associarem a níveis elevados de LDL-c sugere que o metabolismo da LDL pode estar envolvido na síntese de Lp(a). Em pacientes com altos níveis de LDL-c, a Lp(a) é um fator importante na determinação da doença aterosclerótica, bem como da sua gravidade e velocidade de progressão ( 15 ) .…”

Section: Discussionunclassified

“…Accordingly, new risk markers related to lipid metabolism have been identified and studied, among which lipoprotein (a) or Lp(a) stands out because its persistently high plasma levels appear to be strong and independently associated with atherosclerosis ( 3 , 4 ) . Although the mechanisms of action associated with Lp(a) are still unclear, their involvement in atherosclerotic processes is active and silent ( 5 ) .…”

Section: Introductionmentioning

confidence: 99%

“…Nesse sentido, novos marcadores de risco relacionados ao metabolismo lipídico têm sido identificados e estudados, dentre os quais se destaca a lipoproteína (a) ou Lp(a), pois seus níveis persistentemente altos no plasma parecem estar forte e independentemente associados à aterosclerose ( 3 , 4 ) . Embora os mecanismos de ação associados à Lp(a) ainda não tenham sido totalmente esclarecidos, sua participação em processos ateroscleróticos é ativa e silenciosa ( 5 ) .…”

Section: Introductionunclassified

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Lipoprotein (a) and cardiovascular risk factors in children and adolescents

Palmeira

Leal

Ramos

et al. 2013

Rev. paul. pediatr.

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OBJECTIVE: To review the relationship between lipoprotein (a) [Lp(a)] and other risk factors for cardiovascular disease (CVD) in children and adolescents. DATA SOURCES: This systematic review included studies from 2001 to 2011, a ten-year time period. Epidemiological studies with children and/or adolescents published in English, Portuguese or Spanish and fully available online were included. The searches were performed in Science Direct, PubMed/Medline, BVS (Biblioteca Virtual em Saúde) and Cochrane Library databases, using the following combination of key-words: "lipoprotein a" and "cardiovascular diseases" and "obesity". DATA SYNTHESIS: Overall, 672 studies were obtained but only seven were included. Some studies assessed the family history for CVD. In all of them, Lp(a) levels were increased in patients with family history for CVD. There was also a positive correlation between Lp(a) and LDL-cholesterol, total cholesterol, and apolipoprotein B levels, suggesting an association between Lp(a) levels and the lipid profile. CONCLUSIONS: The evidence that CVD may originate in childhood and adolescence leads to the need for investigating the risk factors during this period in order to propose earlier and possibly more effective interventions to reduce morbidity and mortality rates.

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Prevalence and status of Lipoprotein (a) among Lebanese school children

Gannagé‐Yared

Lahoud

Younes

et al. 2020

Sci Rep

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Lipoprotein a (Lp(a) is an independent risk factor for atherosclerotic cardiovascular disease. The prevalence of high Lipoprotein (a) (Lp(a)) in the Lebanese pediatric population is unknown. Our study aims to assess this prevalence and to study the relationship of Lp(a) with the lipid profile, age, body mass index (BMI) and socio-economic status (SES) in Lebanese schoolchildren. A total of 961 children aged 8–18 years (497 boys and 464 girls) were recruited from ten private and public schools in 2013–2014 using a stratified random sample. Schools were selected from the Greater Beirut and Mount Lebanon areas, and were categorized into three subgroups according to the schools’ SES status (high, medium, low). Lp(a) was assayed in 2018 on samples previously frozen at − 80 °C. Abnormal Lp(a) levels (≥ 75 nmol/L) were observed in 14.4% of the overall sample (13.5% for boys,15.3% of girls p = 0.56). The median of Lp(a) was 20(10–50) in the whole sample with no significant gender difference. No significant relationship was found between Lp(a) and age. However, Lp(a) was significantly correlated with BMI in whole sample, as well as in boys and girls (p = 0.02, p = 0.03, p = 0.03, respectively). A significant correlation was found between Lp(a) and non-HDL-C in the whole sample as well as in boys and girls (respectively p < 0.001,p = 0.024 and p = 0.03), but not with triglycerides and HDL-C. In a multivariate linear regression analysis, Lp(a) was only independently associated with BMI and non-HDL-C in boys and girls. Lp(a) was independently associated with BMI and non-HDL-C while no significant relationship was observed with age and sex confirming the strong genetic determination of Lp(a).

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Correlación de los perfiles lipoproteicos y variables antropométricas con concentraciones séricas de lipoproteína(a) en la infancia

Cited by 3 publications

References 17 publications

Association between Lipoprotein (a) Concentration, Glycemic Control and Diabetes Complications in Moroccan Patients with Type 2 Diabetes Mellitus

Association between Lipoprotein (a) Concentration, Glycemic Control and Diabetes Complications in Moroccan Patients with Type 2 Diabetes Mellitus

Lipoprotein (a) and cardiovascular risk factors in children and adolescents

Prevalence and status of Lipoprotein (a) among Lebanese school children

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