Correlación del cociente PSA complex/PSA total con el cociente PSA libre/PSA total, sensibilidad y especificidad de ambos marcadores para el diagnóstico del cáncer de prostata

Pérez-Lanzac-Lorca, A.; Barco-Sánchez, Antonio; Romero, Elaine; Martínez-Peinado, Antonio; López-Elorza, F.; Sanchez-Sanchez, E.; Alvarez-Ossorio-Fernandez, J.L.; Castiñeiras-Fernández, J.

doi:10.1016/j.acuro.2012.11.014

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…A combination of digital rectal examination and PSA level analysis (PSAT and PSAR) represents a screening method that greatly helps in early detection of prostate cancer and in that way allows a prompt action of the clinician. Similarly, when the PSA and DRE levels are normal, the probability of missing the cancer is 10% ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Total PSA Value in Prostate Diseases Diagnosis

Prcic

Begić²,

Hiros

2016

Acta Inform Med

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Introduction:Analysis of total value of prostate specific antigen (PSAT), with the unavoidable digital rectal examination (DRE) is the basis of prostate cancer detection.Aim:The aim of this study was to determine the specificity and sensitivity of the total value of PSAT in the diagnosis of prostate cancer. The aim was also to determine the significance of PSAT in diagnosis of benign prostate hyperplasia, precancerous conditions and inflammatory and atrophic changes of the prostate.Material and methods:Data were collected from the “Register of PH biopsy” of Clinic of Urology, CCU Sarajevo.Results:Analysis of correlation between the diagnosis and the PSAT value shows statistically significant negative correlation (r =-0,186; p = 0.006) in the sense that the value of the PSAT is highest in cancer patients, and the lowest in patients with benign prostatic hyperplasia. PSAT increases with age (r = 0.152; p = 0.025). For prostate cancer optimal sensitivity and specificity for PSAT value occurs at cut off value of> 8.6 ng /mL. Values lower than 2 ng/mL and higher than 10 ng/mL are most specific, and PPV increases with increasing value of PSAT. PSAT at values of <2 ng/mL and > 10 ng/mL are at high levels of specificity, and value > 10 ng / mL is also of high sensitivity in the detection of prostate cancer, and in this moment these values represent the optimal mode for the subsequent treatment.Conclusion:PSAT has a relative significance in the detection of prostate cancer, and should not be used as a guideline without DRE.

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Section: Discussionmentioning

confidence: 99%

Usefulness of Total PSA Value in Prostate Diseases Diagnosis

Prcic

Begić²,

Hiros

2016

Acta Inform Med

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“…Moreover, fPSA% is superior to the total PSA assay in the diagnosis and distinguishing PCa from BPH [7]. Few studies have investigated the e cacy (Sum of speci city and sensitivity %) of serum complexed PSA% (cPSA%) in patients with PCa and BPH [5,8,9]. The highest amount of serum-binding tPSA is bound to α-antichymotrypsin (PSA-ACT) in immunoassays, and as tPSA levels rise, PSA-ACT levels increase [9,10].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic efficiency of calculated complex prostate-specific antigen percentage (cPSA%) for prostate cancer and benign prostate hyperplasia

Omer,

Ismail,

Altayb

et al. 2023

Preprint

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Background Serum cPSA% provides evidence for prostate cancer (PCa) staging and differential diagnosis from benign prostatic hyperplasia (BPH). This study examined the effectiveness of the calculated cPSA% as a diagnostic and prognostic marker for PCa and to differentiate between PCa and BPH. Methods In a case-control study, serum total prostate-specific antigen (tPSA) and free prostate-specific antigen (fPSA) were measured in newly diagnosed PCa and BPH patients. The cPSA% and fPSA% were calculated. The sensitivity and specificity of the tPSA-faction isoforms were analyzed and evaluated in the study groups. Results In PCa, the average cPSA% was significantly higher and fPSA% was lower (86.0 ± 30.4% and 14.0 ± 3.50%, p < 0.001). In the all levels of tPSA, cPSA showed the highest sensitivity and fPSA higher specificity (69%, AUC: 0.723, and 72%, AUC: 0.253). In the tPSA range of 4–10 ng/ml, cPSA% and fPSA% have similar efficiency, whereas, at 10–50 ng/ml, cPSA noticed higher efficiency than fPSA (92%, AUC: 0.549 and 51%, AUC: 0.369). Conclusion The cPSA achieves the requirements of PCa biomarkers and has greater efficiency for the diagnosis of PCa and differentiating it from BPH in gray-zone and late stages.

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