Correlated response of peripheral blood cytokines with selection for reduced mycoplasma pneumonia of swine lesions in Landrace pigs

Sato, Takumi; Okamura, Toshihiro; Kojima-Shibata, Chihiro; Kadowaki, Hiroshi; Suzuki, Eisaku; Uenishi, Hirohide; Suzuki, Keiichi

doi:10.1111/asj.12462

Cited by 12 publications

(19 citation statements)

References 25 publications

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“…increased environmental stress (Bossé et al, 2002). APP is rapidly eliminated by the innate immune response with little interference in the response to other pathogens (Sato et al, 2016), which may explain the positive r G between APP mean and MH found in our study. The r G estimate of MEAN with APP mean was positive and high at all time points, which may be because the serotypes of APP composed most of the Ab responses used to calculate MEAN, in addition to Ab responses to different APP serotypes showing high positive r G with each other.…”

Section: Genetic Parameterssupporting

confidence: 50%

“…Their results are similar to ours, where we obtained an average estimate of h 2 of 0.20 for the 50% seroconverted dataset. In another study, also analyzing the score of mycoplasma pneumonia of swine based on lung lesions in slaughtered pigs after vaccination at 6 and 8 weeks of age, the estimate of h 2 was 0.09 (Sato et al, 2016). These two results are not directly comparable with ours since the animals were experimentally infected and the phenotype analyzed was not the same.…”

Section: Genetic Parametersmentioning

confidence: 58%

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Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds

et al. 2020

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Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds, where selection is performed. One alternative is to use information from the commercial level to identify and select nucleus animals genetically superior for coping with pathogen challenges. In this study, we analyzed the genetic basis of antibody (Ab) response to common infectious pathogens in health-challenged commercial swine herds as potential indicator traits for disease resilience, including Ab response to influenza A virus of swine (IAV), Mycoplasma hyopneumoniae (MH), porcine circovirus (PCV2), and Actinobacillus pleuropneumoniae (APP; different serotypes). Ab response was measured in blood at entry into gilt rearing, post-acclimation (∼40 days after entering the commercial herd), and parities 1 and 2. Heritability estimates for Ab response to IAV, MH, and PCV2 ranged from 0 to 0.76. Ab response to APP ranged from 0 to 0.40. The genetic correlation (r G) of Ab response to IAV with MH, PCV2, PRRSV, and APP mean (average Ab responses for all serotypes of APP) were positive (>0.29) at entry. APP mean was negatively correlated with PCV2 and MH at entry and parity 2 but positively correlated with MH at postacclimation and parity 1. Genomic regions associated with Ab response to different APP serotypes were identified on 13 chromosomes. The region on chromosome 14 (2 Mb) was associated with several serotypes of APP, explaining up to 4.3% of the genetic variance of Ab to APP7 at entry. In general, genomic prediction accuracies for Ab response were low to moderate, except average Ab response to all infectious pathogens evaluated. These results suggest that genetic selection of Ab response in commercial sows is possible, but with variable success depending on the trait and the time-point of collection. Future work is needed to determine genetic correlations of Ab response with disease resilience, reproductive performance, and other production traits.

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Section: Genetic Parameterssupporting

confidence: 50%

Section: Genetic Parametersmentioning

confidence: 58%

Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds

et al. 2020

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“…In our previous study, the heritability of some immunity traits, such as MPS lesions, IL‐10, IL‐13, IL‐17, TNF‐α and IFN‐γ was also estimated low (Sato et al . ). Large environmental effects can be considered as a cause of low heritability estimates.…”

Section: Discussionmentioning

confidence: 97%

Effects of mycoplasmal pneumonia of swine (MPS) lung lesion‐selected Landrace pigs on MPS resistance and immune competence in three‐way crossbred pigs

Borjigin

Shimazu

Katayama

et al. 2016

Animal Science Journal

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To clarify the genetic influence of mycoplasmal pneumonia of swine (MPS) lesion-selected Landrace (La) on MPS resistance and immune characteristics in three-way crossbred pigs (LaWaDa), the LaWaDa pigs were compared with the non-selected crossbred (LbWbDb) and purebred (La) pigs. The MPS lesion score in the three lines was as follows: La line < LaWaDa line < LbWbDb line, with significant differences among the lines. The proportions of myeloid cells and T cells were lower and higher, respectively, in the LaWaDa pigs compared with those in the other two lines. Messenger RNA (mRNA) expression of interleukin (IL)-6, IL-10, transforming growth factor-β, and interferon-γ in peripheral blood was significantly increased after vaccination in the La and LaWaDa lines. IL-4 mRNA expression in the LaWaDa line was intermediate to the La and LbWbDb lines. Furthermore, principal component analysis for immune traits and MPS lesions was executed to clarify the characteristics of each pig line. These findings suggest that the immune responses in the three pig lines are genetically distinct and that MPS resistance and some immunity characteristics from the La line were transmitted to the three-way crossbred pigs.

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“…Sato et al . () reported the strong negative genetic correlation between MPS lesions and IL‐17 and found an increase in the breeding value for IL‐17 with selection in the MPS pulmonary lesion selected La line from the first to fifth generations. However, in this study, the La line did not show a significant increase in IL‐17.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line

Borjigin

Shimazu

Katayama

et al. 2015

Animal Science Journal

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To understand the influence of crossbreeding on Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics, two crossbred lines were characterized. One crossbred line, LaWa, was generated by crossing the MPS pulmonary lesion selected Landrace line (La) and the highly immune-selected Large White line (Wa). The second crossbred line, LaWb, was generated by crossing the La line and the nonselected Large White line (Wb). The crossbred LbWb line (nonselected Landrace line × nonselected Large White line) and the La line were used as controls. The LaWa and LaWb lines had an intermediate level of MPS lung lesions between La and LbWb lines, although the difference was not statistically significant. After stimulation with sheep red blood cells (SRBCs), the LaWb and LaWa lines showed immune characteristics similar to that of the La line; the number of monocytes in peripheral blood increased, while B cells, T cells, secretion of SRBC-specific immunoglobulin G, and interleukin (IL)-13 decreased. Additionally, the number of natural killer (NK) cells and the expression of IL-4 and IL-17 were significantly higher in the LaWb and LaWa lines, respectively. These data suggested that crossbreeding of La and Wa lines resulted in the inheritance of some of the selected immune responses.

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Correlated response of peripheral blood cytokines with selection for reduced mycoplasma pneumonia of swine lesions in Landrace pigs

Cited by 12 publications

References 25 publications

Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds

Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds

Effects of mycoplasmal pneumonia of swine (MPS) lung lesion‐selected Landrace pigs on MPS resistance and immune competence in three‐way crossbred pigs

Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line

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