Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients

Shi, Liang; Nechuta, Sarah; Gao, Yu‐Tang; Zheng, Ying; Dorjgochoo, Tsogzolmaa; Wu, Jie; Cai, Qiuyin; Wang, Zheng; Lü, Wei; Shu, Xiao Ou

doi:10.1371/journal.pone.0086467

Cited by 26 publications

(24 citation statements)

References 31 publications

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“…This study showed that there was no association of vitamin D with tumor characteristics, ER or PR status or stage of breast cancer which is consistent with similar findings in a Chinese population [98]. It is in contrast with research finding of an association of high 25(OH)D concentrations with lower tumor size at early breast cancer diagnosis [99] or ER/PR status of tumor [100].…”

Section: Discussionsupporting

confidence: 87%

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

et al. 2020

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Background The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. Methods A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. Results Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (<20ng/ml), had a higher risk of breast cancer (OR = 1.65, 95%CI: 1.10, 2.50). Women with history of vitamin D supplementation one year prior to enrollment, had significant protective effect against breast cancer (OR = 0.32, 95% CI: 0.24, 0.43). Conclusions and recommendation Serum vitamin D deficiency was associated with increased risk of breast cancer, while vitamin D supplementation was associated with decreased risk of breast cancer.

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Section: Discussionsupporting

confidence: 87%

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

et al. 2020

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“…However, no studies have shown that having early-stage undiagnosed cancer affects 25 (32). A later study in China supported those results (33). Because most breast cancer tumors are diagnosed at stages I and II, most CC studies should not be subject to a cancer effect on 25(OH)D concentration.…”

Section: Resultsmentioning

confidence: 98%

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Grant

2018

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The vitamin D-cancer prevention hypothesis has been evaluated through several types of studies, including geographical ecological studies related to indices of solar ultraviolet-B (UVB) dose (the primary source of vitamin D for most people), observational studies related to UVB exposure or serum 25-hydroxyvitamin D [25(OH)D] concentrations, laboratory studies of mechanisms, and clinical trials. Each approach has strengths and limitations. Ecological studies indirectly measure vitamin D production and incorporate the assumption that vitamin D mediates the effect of UVB exposure. Findings from observational studies with long follow-up times are affected by changing 25(OH)D concentrations over time. Most clinical trials have been poorly designed and conducted, based largely on guidelines for pharmaceutical drugs rather than on nutrients. However, three clinical trials do support the hypothesis. In general, the totality of the evidence, as evaluated using Hill's criteria for causality in a biological system, supports the vitamin D-cancer prevention hypothesis.

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“…Dietary factors associated with increased BC risk included intake of total n-6 polyunsaturated fatty acids (PUFA) (Kiyabu et al, 2015), vitamin D deficiency or insufficiency (Shi et al, 2014a;Park et al, 2015a), high levels of serum cadmium (Nagata et al, 2013;Itoh et al, 2014;Ding et al, 2015), high intake of salt (Park et al, 2014b), sugar (Sulaiman et al, 2014), meat (Ko et al, 2013), and saturated fat and oils (Balasubramaniam et al, 2013;Wang et al, 2013a). In women with BC, the trace elements, cadmium, magnesium, copper, cobalt and lithium, were found in high levels.…”

Section: Dietary Factorsmentioning

confidence: 99%

“…High consumption of fruits and vegetables was associated with decreased BC risk (Sangrajrang et al, 2013), and high intake of fatty foods was associated with increased BC risk (Balasubramaniam et al, 2013;Wang et al, 2013a). Data suggested that an intake of vitamin D, dietary fiber and intake of plant-and soy-based products may be protective for BC (Ko et al, 2013;Li et al, 2013a;Wada et al, 2013;Shi et al, 2014a;Sulaiman et al, 2014;Wang et al, 2014a;Park et al, 2015a), whereas high intake of dietary salt, sugar and meat may increase the risk of BC (Ko et al, 2013;Park et al, 2014b;Sulaiman et al, 2014).…”

Section: Modifiable Risk Factorsmentioning

confidence: 99%

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

105

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Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast neoplasm, epidemiology, Asia, prevalence, incidence, risk and cost of illness. Studies of any design were included, except for review articles and meta-analyses, which were excluded to avoid duplication of data. No exclusions were made based on breast cancer treatment. We reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results: A total of 776 abstracts were retrieved. After screening against the eligibility criteria, 562 abstracts were excluded. The remaining 214 abstracts, which were published between 2013 and 2015, were included in this review. Results were summarized and reported under three categories: incidence, prevalence or outcomes for breast cancer in Asia; modifiable risk factors; and non-modifiable risk factors. We found that the increased risk of breast cancer among participants from Asia was associated with older age, family history of breast cancer, early menarche, late menopause, high body mass index, being obese or overweight, exposure to tobacco smoke, and high dietary intake of fats or fatty foods. In contrast, intake of dietary fruits, vegetables, and plant-and soy-based products was associated with a decreased breast cancer risk. While based on limited data, when compared to women from the United States, women from Asia had a decreased risk of breast cancer. Conclusions: This review of 214 abstracts of studies in Asia, published between 2013 and 2015, confirmed the relevance of known non-modifiable and modifiable risk factors for women with breast cancer.

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Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients

Cited by 26 publications

References 31 publications

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

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