Correlates of cognitive impairment in first episode schizophrenia: The EUFEST study

Galderisi, Silvana; Davidson, Michael; Kahn, René S.; Mucci, Armida; Boter, Han; Gheorghe, M.D.; Rybakowski, Janusz; Libiger, Jan; Dollfus, Sonia; López-Ibor, Juan J; Peuskens, Joseph; Hranov, Luchezar; Fleischhacker, W. Wolfgang

doi:10.1016/j.schres.2009.09.022

Cited by 104 publications

(40 citation statements)

References 37 publications

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“…The recent EUFEST study indicates that the impairment of verbal memory and learning in patients with first-episode schizophrenia or schizophreniform disorder can be improved by antipsychotic drug treatment ). However, this effect is unlikely to be independent of the amelioration of positive and to some degree negative symptoms that correlate with general cognitive improvement Galderisi et al, 2009). Nevertheless, it would be of high interest to use direct receptor imaging to study the role of D2 receptors in cognition in patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Cortical dopamine D2/D3 receptors and verbal memory in man

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Cortical dopamine D2/D3 receptors and verbal memory in man

et al. 2010

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“…Nowadays, the existence of a cognitive deficit in this disorder has been well documented [15]. Cognitive dysfunction is present from the first psychotic episode, or even earlier [16,17,18,19,20,21,22], and is thought to be a primary or core component of the illness [23,24]. Interest in cognition is growing in recent years since cognitive impairment is currently considered to be one of the main factors influencing global functioning and prognosis in schizophrenia [25,26,27,28,29].…”

Section: Introductionmentioning

confidence: 99%

Negative Symptoms and Executive Function in Schizophrenia: Does Their Relationship Change with Illness Duration?

et al. 2012

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Background: Negative symptoms and cognitive dysfunction are of crucial functional and prognostic importance in schizophrenia. However, the nature of the relationship between them and the factors that may influence it have not been well established. Aims: To investigate whether the relationship between negative symptoms and executive function changes according to the duration of illness in schizophrenia. Methods: The Positive and Negative Syndrome Scale was used to assess psychopathology and the Wisconsin Card Sorting Test (WCST) to evaluate executive function in a sample of 200 schizophrenic patients who were classified in 3 groups according to their duration of illness: up to 5 years (short duration group), 6-20 years (intermediate duration group) and over 20 years of illness (long duration group). Results: Medium-sized correlations were found between negative symptoms and WCST performance as assessed by the number of completed categories in all 3 groups. However, differences were found according to the duration of schizophrenia. For patients in the short duration group, negative symptoms correlated with WCST nonperseverative errors, but for those in the long duration group the correlation was with perseverative errors. Conclusion: We found a differential relationship between negative and cognitive symptoms in different stages of schizophrenia. Illness duration should be considered when studying the relationship between negative symptoms and cognition.

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“…This reflects the growing evidence that the majority of individuals with SMI experience cognitive impairment early in the disease course [14], which often does not fully remit despite successful treatment of primary psychiatric symptoms [15][16][17][18], and that cognitive impairment is strongly related to vocational outcomes in this population [19][20][21][22][23][24]. McGurk and Mueser cite several reasons to suspect that the relationship between cognitive impairment and occupational functioning is causative, including empirical findings that cognitive impairment precedes limitations in role functioning, is prospectively related to work outcomes in the general population, is stable over time independent of work status, does not improve with return to work, and is subjectively noted as a barrier to employment success [22].…”

Section: Introductionmentioning

confidence: 72%

Cognitive impairment as barrier to engagement in vocational services among veterans with severe mental illness

O’Connor¹,

Mueller²,

Ormer³

et al. 2011

JRRD

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Abstract-Vocational services (VS), particularly supported employment models, have clear advantages for assisting adults with severe mental illness (SMI) in returning to the workplace, but a majority of eligible individuals with SMI do not receive any type of VS. The reasons for nonparticipation in VS remain poorly understood, and the potential contribution of cognitive impairment as a barrier to entry has not been explored. The present study uses a pathways-to-care design to examine the specific contribution of cognitive functioning to entry into VS among veterans with SMI. We examined 179 veterans with both SMI and un-or underemployment who completed a work history, the Pathways To Care Inventory, and the Trail-Making Test, Part B. Analysis revealed that veterans with SMI and moderate to severe cognitive impairment took significantly longer to progress through pathways-to-care than those with SMI and mild or no cognitive impairment. These results suggest that identifying veterans with SMI and cognitive impairment early and providing them with integrated and adjunct services may help them navigate VS.

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Correlates of cognitive impairment in first episode schizophrenia: The EUFEST study

Cited by 104 publications

References 37 publications

Cortical dopamine D2/D3 receptors and verbal memory in man

Cortical dopamine D2/D3 receptors and verbal memory in man

Negative Symptoms and Executive Function in Schizophrenia: Does Their Relationship Change with Illness Duration?

Cognitive impairment as barrier to engagement in vocational services among veterans with severe mental illness

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