Correlates of plasma fibrinogen (FG) levels in a random sample of community-dwelling elderly

Kostka, Tomasz; Para, Jadwiga; Kostka, B.

doi:10.1016/j.archger.2007.03.011

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…Two manuscripts required translation (French [16] and Japanese [17]). We contacted five authors for additional information, at the time of writing one author had provided useable data [18]. Twenty‐one studies were included in the final systematic review, describing 32 773 participants (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐one studies were included in the final systematic review, describing 32 773 participants (Fig. 1) [18–38].…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen hemostasis or hemorheology biomarkers were described, of which fibrinogen ( n = 17 studies) [18–27,29,30,32–37], D‐dimer ( n = 9 studies) [19,21,22,26,28,32,35,36,38] and plasma viscosity ( n = 7 studies) [24,26,30,31,33,35,36] were most prevalent. Studies varied in methodologies used and potential for bias; no study corrected for all pre‐specified co‐variates (Tables S1 and S2).…”

Section: Resultsmentioning

confidence: 99%

“…Included studies were heterogeneous in terms of study design, biomarker(s) measured and cognitive domains or diagnoses described. Six case–control studies [19–21,28,29,35] and 14 studies describing cross‐sectional or cohort data [18,22–27,30–33,36–38] were included. Only the blood marker fibrinogen was described in a sufficient number of studies to allow for funnel plot analysis.…”

Section: Resultsmentioning

confidence: 99%

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Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta‐analyzes

Quinn¹,

Gallacher²,

Deary³

et al. 2011

Journal of Thrombosis and Haemostasis

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To cite this article: Quinn TJ, Gallacher J, Deary IJ, Lowe GDO, Fenton C, Stott DJ. Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta-analyzes. J Thromb Haemost 2011; 9: 1475-82.Summary. Background and objectives: Hemostasis and thrombosis may be important contributors to cognitive decline and dementia. Certain blood markers may assist in diagnosis or management. Objectives: To collate evidence for the association of circulating hemostatic variables and dementia or cognitive impairment. Methods: A systematic review of studies describing blood markers of hemostatic function and cognition/dementia. Abstracts were reviewed by two independent assessors and studies selected based on pre-specified criteria. We described methodological quality and performed meta-analyzes where data allowed. Results: From 7103 titles, 485 abstracts and included 21 studies (n = 32 773) were assessed. In two longitudinal studies, the incident of vascular dementia risk was greater for higher D-dimer [hazard ratio (HR): 1.50, 95% confidence interval (CI): 1.15-1.96]. For case-control data, we calculated standardized mean differences (SMD) and 95% CI. Higher levels of: factor (F)VII (SMD: 0.93; 95% CI: 0.60-1.26), fibrinogen (SMD: 1.53; 95% CI: 1.17-1.87), prothrombin fragment 1 and 2 (SMD: 0.64; 95% CI: 0.32-0.96), plasminogen activator inhibitor (SMD: 0.68; 95% CI: 0.26-1.10), D-dimer (SMD: 2.00; 95% CI: 1.59-2.40) and von Willebrand factor (VWF) (SMD: 1.68; 95% CI: 1.30-2.06) showed modest but significant associations with vascular dementia. For patients with any dementia diagnosis, associations were with higher D-dimer (SMD: 0.36; 95% CI: 0.15-0.56) and VWF (SMD: 0.31; 95% CI: 0.11-0.51). For specific cognitive domains, significant (P < 0.001) positive correlations were fibrinogen and speed of processing (0.76; 95% CI: 0.67-0.84), verbal memory (0.69; 95% CI: 0.59-0.79) and non-verbal reasoning (0.57; 95% CI: 0.49-0.65). Conclusions:The present results suggest a modest association between hemostasis and vascular dementia including increased levels of thrombin generation markers (D-dimer and prothrombin fragment 1 + 2) and endothelial dysfunction (VWF and plasminogen activator inhibitor). Associations are weaker for specific cognitive tests and when all dementias are combined.

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Section: Resultsmentioning

confidence: 99%

“…Twenty‐one studies were included in the final systematic review, describing 32 773 participants (Fig. 1) [18–38].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta‐analyzes

Quinn¹,

Gallacher²,

Deary³

et al. 2011

Journal of Thrombosis and Haemostasis

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“…As mulheres apresentaram maior prevalência de incapacidade comparada aos homens, entretanto essa associação não foi confirmada por teste estatístico (p<0,05). Há relatos na literatura que mostram associação significante entre dependência e gênero feminino (Rosa et al, 2003;Strauss et al, 2003;Ottenbacher et al, 2005;Parahyba e Simões, 2006;DorantesMendonza et al, 2007;Kostka et al, 2008). A maior prevalência de incapacidade verificada no grupo feminino pode resultar em parte do fato deste grupo apresentar sobrevida maior do que os homens (Strauss et al, 2003;Tabloski, 2004).…”

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Avaliação nutricional, da capacidade funcional e do estresse oxidativo de idosos da cidade de Botucatu - SP

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Cardiovascular diseases (CVD) risk factors, physical activity (PA) and plasma plasminogen (Plg) in a random sample of community-dwelling elderly

Kostka

Para

Kostka

2009

Archives of Gerontology and Geriatrics

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Correlates of plasma fibrinogen (FG) levels in a random sample of community-dwelling elderly

Cited by 6 publications

References 32 publications

Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta‐analyzes

Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta‐analyzes

Avaliação nutricional, da capacidade funcional e do estresse oxidativo de idosos da cidade de Botucatu - SP

Cardiovascular diseases (CVD) risk factors, physical activity (PA) and plasma plasminogen (Plg) in a random sample of community-dwelling elderly

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