Correlates of total homocysteine plasma concentration in type 2 diabetes

Russo, Giuseppina T.; Benedetto, A. Di; Giorda, Carlo; Alessi, Eugenio; Crisafulli, Giovanni; Ientile, Riccardo; Cesare, E. Di; Jacques, Paul F.; Raimondo, Giovanni; Cucinotta, Domenico

doi:10.1111/j.1365-2362.2004.01319.x

Cited by 27 publications

(14 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The elevated level of serum homocysteine in females >50 years old was found to be associated with high levels of serum lipids mainly LDL and triglycerides and low level of HDL (data is not shown), this may shed light on the role of estrogen on the metabolism of homocysteine at menopause and how this could form a risk factor of CHD in females at this age. In this study we are consistent with those of Russo et al (2004) and colleagues (WHO-ISH, 1999), who found age and sex were significantly associated with homocysteine level in type 2 diabetes. There is clear evidence that homocysteine levels can be lowered by administration of supplemental folate, with or without pyridoxine.…”

Section: Discussionsupporting

confidence: 82%

“…Predominant among the causes of mortality and major morbidity is thromboembolism, followed by cerebrovascular accident, peripheral arterial thrombosis and myocardial infarction. Hyperhmocysteinemia, regardless of its cause, is an independent risk factor for stroke, coronary or peripheral artery disease (Russo et al, 2004). The objective of this study is to examine if there is an association between elevated plasma level of homocysteine with age and sex in diabetic and nondiabetic coronary heart disease patients.…”

Section: Introductionmentioning

confidence: 99%

“…Total homocysteine level is a strong predictor of mortality in-patient with an angiographically confirmed coronary heart disease (Russo et al, 2004). Plasma total Homocysteine (tHcy) is commonly elevated in persons with diabetes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Total Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age Groups

Mohammad¹

2010

American Journal of Biochemistry and Biotechnology

View full text Add to dashboard Cite

Problem statement: Elevated plasma total homocysteine concentration is a risk factor of cardiovascular disease. Total homocysteine level is a strong predictor of mortality in-patient with an angiographically confirmed Coronary Heart Disease (CHD), so we want to know at what age in males and females elevated homocysteine will be significantly elevated and this will help for better management and prognosis by decreasing the level of homocysteine. Approach: Plasma level of homocysteine was determined in male and female patients below and above 50 years old, who have coronary heart disease with diabetes or without diabetes. Fifty two coronary heart diseases with type 2 diabetic patients and a matched number of healthy subjects as a control and another 52 coronary heart disease patients without diabetes were included in this study. Plasma homocysteine was determined by Enzymatic Immuno Sorbant Assay (ELISA). Results: Plasma homocysteine level in coronary heart disease diabetic male and female patients who are <50 years old was 10.3±2.5 and 12.66±5.4 umol L −1 , respectively, while it is 28.12±9.5 and 29.44±4.3 umol L −1 in male and female patients >50 years old, respectively. Plasma homocysteine level in coronary heart disease nondiabetic male and female patients who are <50 years old was 12.72±8.5 and 13.60±6 umol L −1 , respectively, while it is 26.9±11.1 and 27.56±6.8 umol L −1 in male and female patients >50 years old, respectively.Conclusion: It is concluded that plasma level of homocysteine is significantly elevated in diabetic coronary heart disease female patients above 50 years old and significantly elevated in nondiabetic coronary heart disease males and female patients, thus nondiabetic coronary heart disease male and female patients and diabetic coronary female patients are at high risk of vascular diseases. It is recommended that these patients may take supplementation of folate and vitamin B12 to reduce the level of homocysteine.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Total Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age Groups

Mohammad¹

2010

American Journal of Biochemistry and Biotechnology

View full text Add to dashboard Cite

show abstract

“…It may be caused by increased production, decreased removal, or both. Although homocysteine concentration is inversely related to renal function (7,15) and is associated with the development of microalbuminuria (16), the precise kinetic mechanism(s) leading to the hyperhomocysteinemia of diabetes with nephropathy has never been investigated. Also, a possible link(s) between insulin resistance and alterations of homocysteine metabolism is largely unknown (12,17).…”

mentioning

confidence: 99%

Effects of Insulin on Methionine and Homocysteine Kinetics in Type 2 Diabetes With Nephropathy

et al. 2005

View full text Add to dashboard Cite

Although hyperhomocysteinemia, an independent cardiovascular risk factor, is common in type 2 diabetes with nephropathy, the mechanism(s) of this alteration is not known. In healthy humans, hyperinsulinemia increases methionine transmethylation, homocysteine transsulfuration, and clearance. No such data exist in type 2 diabetes either in the fasting state or in response to hyperinsulinemia. To this purpose, seven male type 2 diabetic patients with albuminuria (1.2 ؎ 0.4 g/day, three with mild to moderate renal insufficiency) and seven matched control subjects were infused for 6 h with L-[methyl-2 H 3 , 1-13 C]methionine. Methionine flux, transmethylation, and disposal into proteins as well as homocysteine remethylation, transsulfuration, and clearance were determined before and after euglycemic hyperinsulinemia (ϳ1,000 pmol/l). In type 2 diabetic subjects, homocysteine concentration was twofold greater (P < 0.01) and methionine transmethylation and homocysteine clearance lower (from ϳ15 to >50% and from ϳ40 to >100%, respectively; P < 0.05) than in control subjects. The insulin-induced increments of methionine transmethylation, homocysteine transsulfuration, and clearance were markedly reduced in type 2 diabetic subjects (by more than threefold, P < 0.05 or less vs. control subjects). In contrast, methionine methyl and carbon flux were not increased in the patients. In conclusion, pathways of homocysteine disposal are impaired in type 2 diabetes with nephropathy, both in postabsorptive and insulin-stimulated states, possibly accounting for the hyperhomocysteinemia of this condition. Diabetes

show abstract

“…Russo ve ark. [26] , 312 DM'li olgu-da homosistein ile HbA1c ve AKŞ arasında ilişki saptamamış olmamalarına karşın; Abdella ve ark. [20] , 358 tip 2 diyabetli hastada yaptıkları çalışmada homosistein ve HbA1c arasında ilişki saptamışlardır.…”

Section: Hdlkolesterolunclassified

Oral antidiyabetik ilaç kullanan tip 2 diyabetli hastalarda homosistein düzeyleri ve homosistein yüksekliği ile ilişkili faktörler

Sunay¹,

Akkuş²,

Kaya³

et al. 2017

Turk J Fam Pract

View full text Add to dashboard Cite

Amaç: Oral antidiyabetik ilaç kullanan tip 2 diyabet tanılı hastalarda homosistein ve ilişkili faktörleri araştırmak.Gereç ve Yöntem: Çalışmaya Eylül 2008 ve Ocak 2009 tarihlerinde S.B. Ankara Eğitim ve Araştırma Hastanesi Diyabet ve Aile Hekimliği Polikliniklerine başvuran tip 2 diyabet tanılı oral antidiyabetik ilaç kullanan hastalar dahil edildi. Hastaların demografik ve klinik bilgileri kaydedildi. Vücut ağırlıkları, boy, bel çevresi ölçümleri yapıldı, vücut kitle indeksleri (VKİ) hesaplandı. Glukoz, üre, kreatinin, ürik asit, ALT, AST, lipid profili, sodyum, potasyum, HbA1c, homosistein, insülin, vitamin B-12, folik asit ve idrarda mikroalbumin değerleri ölçüldü. HOMA-IR değerleri hesaplandı.Bulgular: Hastaların yaş ortalaması 50,1±9,5 yıl olup, %32,7’si (n=18) erkek, %67,3’ü (n=37) kadındı. Cinsiyet (p=0,162), kadınlarda menopoz durumu (p=0,103) ve sigara içme durumu (0,499) ile homosistein değerleri arasında anlamlı fark saptanmazken, homosistein ile yaş, kreatinin ve ürik asit arasında pozitif, premenopozal kadınlarda homosistein ile yaş arasında pozitif, homosistein ile ALT arasında negatif, postmenopozal kadınlarda homosistein ile yaş, VKİ ve ürik asit arasında pozitif korelasyon saptandı. Sigara içenlerde homosistein ile yaş ve TKŞ arasında pozitif korelasyon bulundu. Homosistein düzeyleri 12 µmol/L olarak alındığında homosistein düzeyleri 12 µmol/L’den yüksek olanlarda ürik asit değerleri anlamlı olmaya yakın düzeyde yüksek saptandı (p=0,053).Sonuç: Bağımsız bir kardiyovasküler hastalık risk faktörü olarak kabul edilen homosistein özellikle başlı başına bir tür kardiyovasküler hastalık olan diyabette önemli görünmektedir. Homosisteine etki eden faktörlerin çokluğu göz önüne alındığında tüm faktörler düzeltilerek yapılacak çok merkezli, geniş çaplı, prospektif çalışmalara ihtiyaç vardır.

show abstract

Correlates of total homocysteine plasma concentration in type 2 diabetes

Abstract: Age, creatinine, folate, vitamin B12, and to a minor extent, sex, smoking, TT genotype and systolic BP were significantly associated with Hcy plasma concentration in type 2 diabetes, whereas no significant associations were noted with diabetes-related variables.

Cited by 27 publications

References 53 publications

Total Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age Groups

Total Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age Groups

Effects of Insulin on Methionine and Homocysteine Kinetics in Type 2 Diabetes With Nephropathy

Oral antidiyabetik ilaç kullanan tip 2 diyabetli hastalarda homosistein düzeyleri ve homosistein yüksekliği ile ilişkili faktörler

Contact Info

Product

Resources

About