Correlation Analysis between Central Corneal Thickness and Intraocular Pressure in Juveniles in Northern China: The Jinan City Eye Study

Wei, Wen Bin; Fan, Zhaoshan; Wang, Lihua; Li, Zhiwei; Jiao, Wanzhen; Li, Yun

doi:10.1371/journal.pone.0104842

Cited by 44 publications

(37 citation statements)

References 39 publications

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“…Therefore, a thinner cornea may lead to underestimation and a thicker cornea overestimation of the true IOP. [16][17][18] In this present study, we found that diabetes and poorer glycemic control have predominately direct associations with higher IOP and only minimal indirect associations through thicker CCT. These findings reassure that high IOP among diabetes is not an overestimate due to thicker CCT.…”

Section: Discussionmentioning

confidence: 68%

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Direct and Indirect Associations Between Diabetes and Intraocular Pressure: The Singapore Epidemiology of Eye Diseases Study

Luo

Tan

Chee

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.The association between diabetes and IOP is controversial; diabetes is associated with thicker central corneal thickness (CCT), and thicker CCT is associated with higher IOP. We therefore aimed to clarify the diabetes-IOP association, considering CCT as a potential mediator. METHODS.We included 8636 participants from the Singapore Epidemiology of Eye Diseases (SEED) Study. Associations of diabetes, serum glucose, or HbA1c with IOP were assessed using regressions models, with adjustments for potential confounding factors. Regressionbased mediation (path) analyses were further performed to evaluate the indirect effects of diabetes on IOP through the mediator (CCT), in addition to the direct effect of diabetes on IOP.RESULTS. Of the 8636 participants, 2524 (29.23%) had diabetes. Diabetes, higher serum glucose, or HbA1c levels were all associated with higher IOP (all P < 0.01). The effect of diabetes on IOP was partially and minimally mediated through CCT; the proportion of mediating effect of CCT was 11.09% of the total effect of diabetes on IOP. Axial length and spherical equivalent were not mediating variables in the diabetes-IOP association. Findings were consistent across three ethnicity groups.CONCLUSIONS. Diabetes or higher long-term hyperglycemia was associated with higher IOP. CCT contributed a small proportion of mediating effect to the total effect of diabetes on IOP. We conclude that high IOP observed in diabetes is mainly due to the direct association of diabetes and IOP, and this finding may have pathophysiologic significance with respect to the risk of glaucoma among persons with diabetes.

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Section: Discussionmentioning

confidence: 68%

“…14,15 Greater CCT may lead to an ''overestimation'' of the true IOP. [16][17][18] It remains unclear whether the diabetes-IOP association is mediated via thicker CCT among persons with diabetes. We hypothesize that thicker CCT in persons with diabetes partially explains the association between diabetes and IOP.…”

mentioning

confidence: 99%

Direct and Indirect Associations Between Diabetes and Intraocular Pressure: The Singapore Epidemiology of Eye Diseases Study

Luo

Tan

Chee

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Thin corneas may lead to an underestimation of IOP, 35,36 but increased IOP in these nontreated Ctns À/À mice may have been caused by corneal sclerosis or scarring. 37 In contrast, physiological IOPs were observed in the HPSC-engrafted Ctns À/À mice.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation

Rocca

Kreymerman

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Cystinosis is caused by a deficiency in the lysosomal cystine transporter, cystinosin (CTNS gene), resulting in cystine crystal accumulation in tissues. In eyes, crystals accumulate in the cornea causing photophobia and eventually blindness. Hematopoietic stem progenitor cells (HSPCs) rescue the kidney in a mouse model of cystinosis. We investigated the potential for HSPC transplantation to treat corneal defects in cystinosis. METHODS. We isolated HSPCs from transgenic DsRed mice and systemically transplanted irradiated CtnsÀ/À mice. A year posttransplantation, we investigated the fate and function of HSPCs by in vivo confocal and fluorescence microscopy (IVCM), quantitative RT-PCR (RTqPCR), mass spectrometry, histology, and by measuring the IOP. To determine the mechanism by which HSPCs may rescue disease cells, we transplanted Ctns À/À mice with Ctns À/À DsRed HSPCs virally transduced to express functional CTNS-eGFP fusion protein. RESULTS. We found that a single systemic transplantation of wild-type HSPCs prevented ocular pathology in the CtnsÀ/À mice. Engraftment-derived HSPCs were detected within the cornea, and also in the sclera, ciliary body, retina, choroid, and lens. Transplantation of HSPC led to substantial decreases in corneal cystine crystals, restoration of normal corneal thickness, and lowered IOP in mice with high levels of donor-derived cell engraftment. Finally, we found that HSPC-derived progeny differentiated into macrophages, which displayed tunneling nanotubes capable of transferring cystinosin-bearing lysosomes to diseased cells.CONCLUSIONS. To our knowledge, this is the first demonstration that HSPCs can rescue hereditary corneal defects, and supports a new potential therapeutic strategy for treating ocular pathologies.

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“…Studies have shown specular microscopy measurements of CCT are considerably lower than ultrasound pachymetry measurements of CCT [7, 14]. In our study, corresponding to parents’ consent only a single contact measurement was taken, and therefore, the authors decided to measure IOP with gold standard Goldmann applanation tonometer and CCT measurement was documented with noncontact specular microscope.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies found a relationship between ethnicity and IOP. In addition, IOP and CCT values have proven to be different among children from various races including black and white [5, 6], Chinese [7, 8], Turkish [9], Japanese [10], Indian [11] and Malay pediatric population [12]. …”

Section: Introductionmentioning

confidence: 99%

Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children

et al. 2016

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IntroductionThis study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements.MethodsThis cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma. Specular microscopy was used to measure CCT and both noncontact tonometry (NCT) and Goldmann applanation tonometer (GAT) were used to measure IOP. Correlations between IOP measurements were also examined.ResultsMean CCT was 513.47 ± 34.51 μm in the right eye (OD) and 513.93 ± 33.88 μm in the left eye (OS). The CCT was not significantly different between older (10–13 years) and younger (6–9 years) patients. Mean IOP measured with GAT was 13.86 ± 2.13 mmHg OD and 13.72 ± 2.04 mmHg OS and mean IOP measured with NCT was 15.26 ± 2.38 mmHg OD and 15.11 ± 2.18 mmHg OS. The IOP and CCT measured with GAT were weakly correlated (OD: r = 0.141, P = 0.114; OS: r = 0.236, P = 0.007). However, IOP and CCT measured with NCT (OD: r = 0.487, P = 0.000; OS: r = 0.456, P = 0.000) were moderately correlated. Our outcomes demonstrated that for 100 μm increase in CCT, IOP measured with GAT and NCT increased by 0.8 and 3.3 mmHg, respectively, in OD and by 1.4 and 2.9 mmHg in OS. Based on intraclass correlation coefficients, IOP measurements made with GAT and NCT were in fair agreement in OD and in good agreement in OS.ConclusionThe IOP and CCT in healthy Persian school children (6–13 years old) were positively correlated. Our findings revealed that corneal thickness is thinner in Persian children than in most other racial groups.FundingThis study has been funded by deputy dean in research of School of Medicine and deputy vice chancellor of Shiraz University of Medical Sciences, Shiraz, Iran.

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Correlation Analysis between Central Corneal Thickness and Intraocular Pressure in Juveniles in Northern China: The Jinan City Eye Study

Cited by 44 publications

References 39 publications

Direct and Indirect Associations Between Diabetes and Intraocular Pressure: The Singapore Epidemiology of Eye Diseases Study

Direct and Indirect Associations Between Diabetes and Intraocular Pressure: The Singapore Epidemiology of Eye Diseases Study

Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation

Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children

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