Correlation Analysis of Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Frailty in Elderly Patients With Coronary Heart Disease

Qu, Jiling; Zhou, Ting; Xue, Mengxin; Sun, Hongyan; Shen, Yijing; Chen, Yuhui; Tang, Lei; Lin, Qian; You, Jiachun; Yang, Ruohan; Liu, Yongbing

doi:10.3389/fcvm.2021.728800

Cited by 35 publications

(41 citation statements)

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“… 32 Mohindra et al 33 showed that a proposed RDW index could potentially be an important parameter in predicting the prognosis of ischemic stroke patients. In the past two years, HRR has been widely reported as an important observation indicator of cancer prognosis.Both hemoglobin and RDW are important components of HRR, and the relationship between lower hemoglobin, higher RDW, and frailty in elderly CHD patients has been confirmed, lower HRR is associated with increased frailty risk and has a certain predictive value in elderly hospitalized patients with CHD, 11 our study is consistent with previous finding. In this study, we expounded on that finding.…”

Section: Discussionsupporting

confidence: 92%

“… 6 In recent years, a series of studies on the HRR and prognosis of cancer patients have been reported, 7–10 and a few studies on the HRR and prognosis of coronary heart disease patients have been reported. 11 So far, However, there is no relevant report studies HRR on the prognosis of severe ischemic stroke patients with AF and the correlation of adverse events. To the best of our knowledge, this is one of the first studies using the MIMIC-IV database to research the results of ischemic strokes combined with AF.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database

Qin¹,

Liao²,

Lü³

et al. 2022

NDT

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Aim To investigate the association between the hemoglobin-to-red cell distribution width (RDW) ratio (HRR) and all-cause mortality in ischemic stroke patients with atrial fibrillation (AF). Design This study was a retrospective cohort analysis. In total, 1018 ischemic stroke patients with AF were enrolled using the Medical Information Mart for Intensive Care database, (MIMIC)-IV. The patients were divided into four groups according to the HRR values. The primary outcome was 180-day all-cause mortality. Methods Multivariate Cox proportional risk regression models were used to examine the association between HRR and all-cause mortality. The non-linear relationship between HRR and all-cause mortality was confirmed using a Cox proportional risk regression model fitted by cubic spline function and smooth curve fitting. Results A total of 246/1018 patients (24.17%) died. The serum HRR values were negatively associated with 180-day all-cause mortality (hazard ratio (HR) 0.80, 95% confidence interval (CI) 0.68–0.94). A two-piecewise regression model was used to obtain a threshold inflection point value of 9.74. The HR and the 95% CI on the left inflection point were 0.73 and 0.61–0.87 (p = 0.0005); on the right inflection point they were 1.06 and 0.82–1.38 (p = 0.6383). Conclusion The relationship between all-cause mortality and the HRR values was non-linear in ischemic stroke patients with AF. All-cause mortality and HRR values were negatively correlated when the HRR value was ≤9.74.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database

Qin¹,

Liao²,

Lü³

et al. 2022

NDT

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“…The red blood cell distribution width coefficient of variation (RDW-CV) is a quantitative estimate of the heterogeneity of red blood cell volume (RBC), commonly known as anisocytosis. There may be a possible association between elevated RDW and inflammation [ 16 , 17 , 18 , 19 ]. Inflammatory responses negatively affect red blood cell production [ 17 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…There may be a possible association between elevated RDW and inflammation [ 16 , 17 , 18 , 19 ]. Inflammatory responses negatively affect red blood cell production [ 17 , 20 ]. Many of the pro-inflammatory cytokines upregulated in COVID-19, such as tumor necrosis factor-α and interleukin-1, can cause lowering of erythropoietin production [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Molnupiravir as an Early Treatment for COVID-19: A Real Life Study

et al. 2022

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Objectives: Below we report our experience in the use of molnupiravir, the first antiviral drug against SARS-CoV-2 available to us, in the treatment of patients with COVID-19. Materials and Methods: We enrolled patients diagnosed with COVID-19 and comorbidities who were candidates for antiviral drug therapy. All patients received molnupiravir (800 mg twice daily). Blood chemistry checks were carried out at T0 and after 7/10 days after starting therapy (T1). Results: There were enrolled within the cohort 100 patients. There was 100.0% compliance with the antiviral treatment. No patient required hospitalization due to worsening of respiratory function or the appearance of serious side effects. The median downtime of viral load was ten days (IQR 8.0–13.0), regardless of the type of vaccination received. The patients who had a shorter distance from vaccination more frequently presented vomiting/diarrhea. During baseline and T1 we found significant differences in the median serum concentrations of the main parameters, in particular of platelets, RDW CV, neutrophils and lymphocytes, the eGFR, liver enzymes, as well as of the main inflammatory markers, CRP and Ferritin. Conclusion: Participants treated with molnupiravir, albeit in risk categories, demonstrated early clinical improvement, no need for hospitalization, and a low rate of adverse events.

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“… 10 Subsequently, Qu et al demonstrated that Hb/RDW is an independent risk factor for predicting frailty in patients with coronary heart disease. 11 They both found Hb/RDW to be a better prognostic indicator than either Hb alone or RDW by itself. This is considered that Hb/RDW combining Hb and RDW can provide more information than a single variable.…”

Section: Introductionmentioning

confidence: 97%

Association of Hemoglobin to Red Blood Cell Distribution Width-Standard Deviation (RDW-SD) Ratio and 3-Month Readmission in Elderly Chinese Patients with Heart Failure: A Retrospective Cohort Study

Song¹,

Yu²,

Yan³

et al. 2023

IJGM

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Purpose Hemoglobin (Hb) and red blood cell distribution width-standard deviation (RDW-SD) have clinical significance in the prognosis of heart failure (HF). Little is known regarding the prognostic value of the Hb/RDW-SD ratio in patients with HF. This study sought to investigate the association between Hb/RDW-SD ratio and HF 3-month readmission in Chinese elderly patients. Patients and Methods The present study was a retrospective cohort study. A total of 1816 HF patients were extracted from the Chinese HF database. A generalized linear model was used to explore the association between Hb/RDW-SD and 3-month readmission in HF. The generalized additive model was used to explore the nonlinear relationship, and a two-piecewise linear regression model was used to find the inflection point. Subgroup analysis explored interactions and whether each subgroup was consistent with the primary outcome direction. Results Result showed Hb/RDW-SD was negatively associated with HF 3-month readmission (OR = 0.70, 95% CI: 0.55 to 0.89, P = 0.0031). A non-linear relationship was detected between Hb/RDW-SD and HF 3-month readmission with two inflection points (1.78 and 2.17). Both Hb/RDW-SD < 1.78 and Hb/RDW-SD > 2.17 showed a significant correlation between them, with corresponding effect values of (OR = 0.38, 95% CI: 0.17 to 0.87, P = 0.0209) and (OR = 0.44, 95% CI: 0.27 to 0.71, P = 0.0007), respectively. Conclusion Hb/RDW-SD is negatively associated with HF 3-month readmission. The relationship between Hb/RDW-SD and HF 3-month readmission is also non-linear. Both Hb/RDW-SD < 1.78 and Hb/RDW-SD > 2.17 were strong negatively associated with HF 3-month readmission.

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Correlation Analysis of Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Frailty in Elderly Patients With Coronary Heart Disease

Cited by 35 publications

References 35 publications

Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database

Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and All-Cause Mortality in Ischemic Stroke Patients with Atrial Fibrillation: An Analysis from the MIMIC-IV Database

Molnupiravir as an Early Treatment for COVID-19: A Real Life Study

Association of Hemoglobin to Red Blood Cell Distribution Width-Standard Deviation (RDW-SD) Ratio and 3-Month Readmission in Elderly Chinese Patients with Heart Failure: A Retrospective Cohort Study

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