Correlation analysis of severe aplastic anemia immunosuppressive therapy and human leukocyte antigen alleles in pediatric patients

Fu, Ru-Ting; Hou, Xue; Zhang, Bihong; Wang, Jian; Lin, Shaofen; Chen, Chun

doi:10.3892/etm.2015.2807

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…From the results of this study, the allele frequencies of the HLA loci in the population enrolled in this study were fundamentally the same as previously reported. For example, in this study, the alleles with frequencies of more than 10% at HLA-A locus were A*1101 (19.14%), A*2402 (18.18%), and A*0201 (12.87%), which was similar to Hei AL et al [3] and Deng YJ et al [12] , and was also consistent with the frequencies…”

Section: Discussionsupporting

confidence: 89%

“…Many researches have reported the difference in HLA allele frequency between hematological disease patients and healthy volunteers. For example, Fu RT et al [13] found that HLA-B*1502, -B*1511, -DQB1*0303 and -DQB1*0602 had correlation with the effects of immunosuppressive therapy in severe pediatric aplastic anemia patients. Al-Tonbary Y et al [14] reported that HLA-DQB1*0201 might be the susceptible gene in Non-Hodgkin's lymphoma, while HLA-DQB1*0502 and -DQB1*0602 might be protective genes for it.…”

Section: Table 5 Common (Hf>2%) Hla Two-locus Haplotypes In 663 Familiesmentioning

confidence: 99%

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Distribution of HLA class Ⅰ and class Ⅱ haplotypes in Chinese Han population based on family segregation

Wang¹,

Li²,

Wang³

et al. 2021

Blood and Genomics

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HLA haplotype analysis has important application value in human population genetics, anthropological research and HLA matching transplantation. Based on HLA-A, -B, -C, -DRB1 and -DQB1 genotyping data from 663 families including 663 leukemia patients and 991 related donors, the allele frequency (AF) and haplotype frequency (HF) of two-, three-and five-locus haplotype distribution patterns in the Chinese Han population were determined by family segregation. A total of 38 alleles at A locus, 75 alleles at B locus, 35 alleles at C locus, 53 alleles at DRB1 locus and 22 alleles at DQB1 locus were discovered in this population. The frequencies of these alleles were basically consistent with those of previous reports except for some tiny differences. The study found 11 A-C, 15 C-B, 4 B-DRB1 and 11 DRB1-DQB1 two-locus haplotypes with a frequency over 2%. The number of A-C-B and A-B-DRB1 three-locus haplotype with a frequency over 1% were 11 and 3 respectively. The most common HLA-A-C-B-DRB1-DQB1 haplotype (HF>1%) were A*3001-C*0602-B*1302-DR*0701-DQ*0202 (4.30%), A*0207-C*0102-B*4601-DR*0901-DQ*0303 (3.07%), A*3303-C*0302-B*5801-DR*0301-DQ*0201 (1.49%) and A*1101-C*0102-B*4601-DR*0901-DQ*0303 (1.01%). The results are helpful for finding matching donors for hematopoietic stem cell transplant patients and also contribute to transplant immunology, HLA-related diseases, research of human genetics and other fields.

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Section: Discussionsupporting

confidence: 89%

Section: Table 5 Common (Hf>2%) Hla Two-locus Haplotypes In 663 Familiesmentioning

confidence: 99%

Distribution of HLA class Ⅰ and class Ⅱ haplotypes in Chinese Han population based on family segregation

Wang¹,

Li²,

Wang³

et al. 2021

Blood and Genomics

View full text Add to dashboard Cite

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Assessment of association between HLA alleles and acquired aplastic anemia in Iranian population

Taheri

Akbari²,

Ostadali

et al. 2021

Ecological Genetics and Genomics

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Comparative study of the diversity of amino acids on human leucocyte antigen class II molecules in patients with acquired aplastic anaemia

Qi,

Wang,

Wang

et al. 2024

Br J Haematol

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SummaryHuman leucocyte antigen (HLA) class II molecules are critically involved in the pathology of acquired aplastic anaemia (AA) by regulating the immune response and autoreactive T cell‐mediated haematopoietic cell death. In the study, amino acid residue variation and molecular structure of HLA class II have been initially investigated in 96 patients with AA. The frequencies of residues 9 and 57 in pocket 9 (P9) in DQB1, and amino acid positions 9, 11, 13, 16, 26, 38, 67 and 71 in the P4, P6 and P9 pockets in DRB1 were more prevalent among AA patients. By applying a multivariate recursive approach, the DRβ‐Gln‐16 (OR = 3.003, 95% CI = 1.468–6.145, pc = 0.003), DRβ‐Ala‐71 (OR = 1.924, 95% CI = 1.233–3.002, pc = 0.004) in P4/P7 and DQβ‐Asp‐57 (OR = 3.483, 95% CI = 1.079–11.242, pc = 0.037) in P9, these critical residues were significantly discovered as risk amino acid residues on the onset of AA, as well as associated with PNH‐type cells and pathological somatic or cytogenetic mutations. In silico structural model analysis showed that identified DRβ‐Ala‐71 and DQβ‐Asp‐57 within the antigen‐binding groove interacting with a more variable antigenic segments, may impact the repertoire of peptides presented, influence the interface HLA‐antigen‐T‐cell receptor β (TCR β). These findings provided light on the immunogenetic pathophysiology of AA aetiology and their potential impact on upcoming immunotherapies.

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Correlation analysis of severe aplastic anemia immunosuppressive therapy and human leukocyte antigen alleles in pediatric patients

Cited by 4 publications

References 24 publications

Distribution of HLA class Ⅰ and class Ⅱ haplotypes in Chinese Han population based on family segregation

Distribution of HLA class Ⅰ and class Ⅱ haplotypes in Chinese Han population based on family segregation

Assessment of association between HLA alleles and acquired aplastic anemia in Iranian population

Comparative study of the diversity of amino acids on human leucocyte antigen class II molecules in patients with acquired aplastic anaemia

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