Correlation Analysis of TSB Level and Globus Pallidus-Related Metabolite Indexes of Proton Magnetic Resonance Spectroscopy in the Newborn with Neonatal Jaundice

Abstract

Objective. To investigate the correlation between serum total serum bilirubin (TSB) levels and globus pallidus-related metabolic indexes of proton magnetic resonance spectroscopy (1H-MRS) in the newborn with neonatal jaundice. Methods. 50 children with neonatal jaundice admitted to our hospital from January 2019 to January 2021 were recruited and assigned to a mild condition group (TSB < 221 μmol/L, n = 16), a moderate condition group (221 μmol/L ≤ TSB < 3 42 μmol/L, n = 18), and a severe condition group (342 μmol/L ≤ TSB < 428 μmol/L, n = 16) based on peak TSB. The differences in globus pallidus-related metabolic indexes of 1H-MRS between the groups were compared and their correlation with TSB levels was analyzed. Results. The three groups had comparable N-acetylaspartic acid (NAA)/creatine (Cr), choline (Cho)/Cr, lactic acid (Lac)/Cr, and ml/Cr levels ( P > 0.05 ), while there were statistical differences in glutamine (Glx)/Cr levels ( P < 0.05 ). The severe condition group showed the highest levels of neuron-specific enolase (NSE), creatine kinase-MB (CK-MB), and troponin (cTnl), followed by the moderate group, and then the mild group ( P < 0.05 ). The TSB level is positively correlated with the 1H-MRS metabolic index Glx/Cr. Conclusions. The serum TSB level is correlated with the 1H-MRS metabolic index Glx/Cr in the newborn with neonatal jaundice, and the levels of TSB and Glx/Cr provide a reference for the diagnosis of bilirubin encephalopathy.

A Non-invasive Methods for Neonatal Jaundice Detection and Monitoring to Assess Bilirubin Level: A Review

“…In infants with jaundice, Liu et al [31] evaluated the relationship between total serum bilirubin (TSB) levels and globus pallidus-related metabolic markers of proton magnetic resonance spectroscopy (1H-MRS). They examined the relationship between their hypothesized categories of globus pallidus-related 1H-MRS metabolic indices and TSB concentrations.…”

Retracted: Correlation Analysis of TSB Level and Globus Pallidus‐Related Metabolite Indexes of Proton Magnetic Resonance Spectroscopy in the Newborn with Neonatal Jaundice

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”