Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules

Su, J J; Liu, Hui; Cheng, Xi; Su, Guoqiang

doi:10.4238/2015.january.15.2

Cited by 12 publications

(6 citation statements)

References 26 publications

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“…Ki67 frequently exhibits increased expression in patients with anaplastic carcinoma and malignant nodule tumors (22,23). In the present study, it was observed that SERPINE2 knockdown reduced Ki67 and PCNA expression levels.…”

Section: Discussionsupporting

confidence: 61%

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

Chu

2021

Mol Med Rep

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Section: Discussionsupporting

confidence: 61%

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

Chu

2021

Mol Med Rep

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“…In our study, we analyzed the classification of benign and malignant nodules using measures of thyroid function. Changes in FT4, FT3, TSH, and TG are common indicators of changes in thyroid function (12)(13)(14)(15). These indicators were analyzed and modeled; both FT4 and FT3 had significant effects on malignant nodules and were key factors that could be used to diagnose benign and malignant nodules.…”

Section: Association Between Thyroid Function Tests and Nodule Classi...mentioning

confidence: 99%

The analysis of differential diagnosis of benign and malignant thyroid nodules based on ultrasound reports

et al. 2020

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Background: Thyroid cancer is a common endocrine tumor, the incidence of which is increasing each year.Early diagnosis and treatment can effectively prevent thyroid cancer. This article uses Chinese's ultrasound reports to determine the value of early diagnosis. Methods:The clinical data center of the First Affiliated Hospital of Nanjing Medical University was screened for patients diagnosed with a thyroid nodule, who had undergone a thyroid function test, ultrasound records and pathological assessment. A total of 811 patients with a total of 1,290 pathologically confirmed nodules (506 benign and 784 malignant) were enrolled. Logistic regression was used to analyze the variables that significantly affected malignant nodules. The sensitivity and specificity of ultrasound thyroid imagingreporting and data system (TI-RADS) classification results for benign and malignant tumors were calculated.Results: The age of the patients had a very significant difference in the classification of benign and malignant nodules (P<0.001), and the marital status was significantly different (P<0.05). Gender and medical insurance had no significant effect (P>0.05). Thyroglobulin (TG), free thyroxine (FT4), and free triiodothyronine (FT3) had significant effects (P=0.003) on the incidence of malignant nodules in patients, while thyroid-stimulating hormone (TSH) had no significant effect (P>0.05). Ultrasound analysis showed a Youden's index of 78.97%, a positive predictive value of 93.20%, and a negative predicted value of 84.10% at the most excellent classification effect. The sensitivity was 89.0%, the specificity was 89.9%; much greater than the classification model based on the thyroid function test (sensitivity =80.6%, specificity =55.8%). Conclusions:The present study verifies the effectiveness of using TI-RADS classification for diagnosis of benign and malignant thyroid nodules, and explores the use of new analysis methods for clinical data. To reduce dependence on the doctors, ultrasound image data and clinical phenotypic data can be further used to assist clinical decision making.

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“…Thyroid cancer (TC) is a malignant tumor derived from thyroid epithelial cells, and the increased incidence of TC is a serious concern. 1,2 At present, the specific molecular mechanism of TC has not been reported. Like other malignancies, the external environmental and intracorporal genetic are known to be important factors influencing the pathogenesis of TC.…”

Section: Introductionmentioning

confidence: 98%

IL‐1RN gene polymorphisms reduces thyroid cancer risk in Chinese Han population

Zhao

et al. 2020

Molecular Carcinogenesis

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The purpose of this study was to investigate the effect of IL‐1RN polymorphisms on thyroid cancer (TC) risk in Han population. Genotypes of four single nucleotide polymorphisms (SNPs) (rs17042888, rs928940, rs3181052, and rs452204) were analyzed by Agena MassARRAY. Meanwhile, we used the logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), and significant differences were evaluated by t test and χ2 test. Findings found that allele “G” of rs452204 and rs3181052 in interleukin‐1 receptor antagonist (IL‐1RN) reduced the risk of TC. (OR = 0.72, 95% CI = 0.55‐0.94, p = .017; OR = 0.73, 95% CI = 0.56‐0.94, p = .017, respectively). Hierarchical analysis indicated that three SNPs (rs17042888, rs3181052, and rs452204) significantly reduced the risk of TC among females or individuals older than 48 years (p < .05). Our findings indicate that IL‐1RN polymorphisms may contribute to a protective role against TC risk.

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Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules

Cited by 12 publications

References 26 publications

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells

The analysis of differential diagnosis of benign and malignant thyroid nodules based on ultrasound reports

IL‐1RN gene polymorphisms reduces thyroid cancer risk in Chinese Han population

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