Correlation and Cross-Linking Effects in Imprinting Sites for Divalent Adsorption in Gels

Stancil, Kimani A.; Feld, Michael S.; Kardar, Mehran

doi:10.1021/jp045858f

Cited by 13 publications

(4 citation statements)

References 14 publications

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“…The development of alternatives to the synthesis of traditional monolithic polymers has been driven by both practical considerations, for example, ease of scale‐up, requirements for integration with other technologies, such as sensors, and for performance issues, for example, mass transfer or flow properties. Methods for preparation of discrete MIP particles, composites and molecularly imprinted polymer surfaces and fibers are areas that have been gaining in prominence over recent years and now constitute a significant portion of the original literature published in the molecular imprinting field …”

Section: Fundamental Aspectsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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SummaryHerein we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004 to 2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004 which were omitted in the first instalment of this series covering the years 1930 to 2003. 1 In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed.2

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Section: Fundamental Aspectsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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“…To meet the third condition, that is, the minimization of the frustration, the 'imprinting technique' [63][64][65][66][67] was adopted. In this section, we discuss the early experimental successes [77][78][79][80][81][82][83][84] of the imprinting method and the application of the Tanaka equation to imprinted gels.…”

Section: Applications To Imprinted Gel Systemsmentioning

confidence: 99%

“…We then review the experiments that have been done on adsorption of target molecules by random gels, detailing the dependence of their adsorption affinity on adsorber monomer concentration [21], salt concentration [75], and cross-linker concentration [76]. We then compare the properties of random and imprinted gels and show the early successes of the imprinting method [77][78][79][80][81][82][83][84].…”

Section: Introductionmentioning

confidence: 99%

Multiple point adsorption in a heteropolymer gel and the Tanaka approach to imprinting: experiment and theory

Ito

Chuang

Alvarez‐Lorenzo

et al. 2003

Progress in Polymer Science

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Heteropolymer gels can be engineered to release specific molecules into or absorb molecules from a surrounding solution. This remarkable ability is the basis for developing gel applications in extensive areas such as drug delivery, waste cleanup, and catalysis. Furthermore, gels are a model system for proteins, many of whose properties they can be created to mimic. A key aspect of gels is their volume phase transition, which provides a macroscopic mechanism for effecting microscopic changes. The phase transition allows one to control the gel's affinity for target molecules through tiny changes in the solution temperature, salt concentration, pH, or the like. We summarize recent experiments that systematically characterize the gel affinity as a function of adsorbing monomer concentration, solution salt concentration, and cross-linker concentration, on both sides of the phase transition. We provide a physical theory that explains the results and discuss enhancements via imprinting.

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“…4 Generally, materials with molecular recognition ability are molecular imprinting polymers (MIPs), which are commonly prepared by molecular imprinting technique (MIT). 5 MIPs are artificial, template-made receptors with the ability to recognize and bind targeted molecules. Besides the general preparation process for materials, the preparation of MIPs involves a preinteraction between the imprinted molecule and functional monomers or polymers either by covalent or noncovalent interactions, such as the electrostatic force, hydrogen bonding, and metal ion coordination, or both covalent and noncovalent interactions, as well as desorption of the imprinted molecules.…”

Section: Introductionmentioning

confidence: 99%

Protein recognition via molecularly imprinted agarose gel membrane

Lin

Tang

Xuan

2007

J Biomedical Materials Res

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Agarose gel membranes (AGMs), which could selectively recognize bovine serum albumin (BSA) and bovine hemoglobin (Hb), were prepared by molecular imprinting technique under moderate preparation conditions. Four imprinting processes, including gelation without any treatment, second gel-melting, and two glutaraldehyde crosslinking processes of fumigation or direct addition of the crosslinking agent, were developed to investigate the protein-recognition behavior of the AGMs. Results showed that the preparation processes affected the adsorption capacity and selectivity of the imprinted AGMs. Both BSA- and Hb-imprinted AGMs exhibited higher adsorption abilities for the targeted proteins (3.77-5.72 times for BSA, 1.31-2.18 times for Hb) than the nonimprinted ones. And the selectivity of BSA-imprinted AGMs for BSA molecules (the selective factor K = 3.29-4.90) was higher than that of Hb-imprinted AGMs for Hb (K = 0.32-1.17). The optimal adsorption capacity of BSA- and Hb-imprinted AGMs was 25.90 and 117.45 mg/g, respectively, when the membrane was crosslinked by glutaraldehyde with a fumigation process; the optimal selectivity of BSA- and Hb-imprinted AGMs was 4.91 when the membrane was prepared by second gel-melting process, and 0.76 when the membrane was prepared without any treatment. These findings demonstrate that the molecularly imprinted AGMs are hopeful to be used in specific protein analysis.

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Correlation and Cross-Linking Effects in Imprinting Sites for Divalent Adsorption in Gels

Cited by 13 publications

References 14 publications

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Multiple point adsorption in a heteropolymer gel and the Tanaka approach to imprinting: experiment and theory

Protein recognition via molecularly imprinted agarose gel membrane

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