Correlation and Prediction of Oxygen Index from Oxygen Saturation Index in Neonates with Acute Respiratory Failure

Abstract

Objective: To evaluate the correlation between the oxygen index (OI) and the oxygen saturation index (OSI, measured by pulse oximetry and noninvasively) in neonates with acute respiratory failure and to predict the OI from the OSI. Study Design: A retrospective cohort study was conducted in neonates requiring invasive mechanical ventilation who had arterial blood gas between 2018 to 2019 at a neonatal intensive care unit. The correlation between OI and OSI was analyzed by using the Pearson correlation coefficient. Results: A total of 636 measurements from 68 neonates (35 preterm and 33 terms) were recruited into the study. There was a strong correlation between the OI and the OSI (r = 0.90) in all neonates. The correlation between the OI and the OSI in persistent pulmonary hypertension of the newborn, congenital cyanotic heart disease, and other causes of respiratory failure also showed a strong correlation (r = 0.88, 0.93, and 0.88, respectively). The correlation was strong in neonates with an oxygen saturation less than 85% (r = 0.88), those with oxygen saturation ranging from 85% to 95% (r = 0.87), and also in preterm and term infants (gestational age < 28, 28−34, 34−36, and ≥ 37 weeks, r = 0.87, 0.92, 0.89, and 0.90, respectively). There were strong accuracy measures of the OI for OI cutoffs of 5, 10, 15, and 20 (area under the curve > 0.85). The equation relating the OI and OSI was represented by: OI = (2.3 × OSI) – 4. Conclusions: The OSI has a strong correlation with the OI, is a reliable assessor of the severity of respiratory failure in neonates without arterial sampling, and has high accuracy when the OI < 40.

Respiratory parameters as a predictor of hospital outcomes in newborns requiring medical evacuation

“…В работе g. Maneenil и соавт. [15] продемонстрирована достоверная, сильная корреляционная связь между обоими вариантами индекса оксигенации, коэффициент корреляции составил от 0,88 до 0,93 в зависимости от нозологии и сохранил значение 0,88 при сатурации менее 85 %. Подобные результаты получены H.K.…”

Predicting the need for intensive care correction during pre-transport stabilization of newborns, requiring medical evacuation

“…N. Khalesi et al указывают на клинически приемлемую точность сатурационного индекса оксигенации, близкую к традиционному индексу оксигенации [29]. В работе G. Maneenil et al продемонстрирована достоверная, сильная корреляционная связь между обоими вариантами индекса оксигенации, коэффициент корреляции составил от 0,88 до 0,93 в зависимости от нозологии, в том числе и при низких значениях сатурации [30]. Аналогичные результаты публикует H.K.…”

Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome

“…69 The initial derivation of the OSI was shown to have reasonable sensitivity and specificity for defining acute lung injury and ARDS among children using AECC criteria, 69 and a strong linear relationship between the OI and the OSI has been described in paediatric populations. 10,70,71 The OI or OSI thresholds are used as the hypoxaemia criteria for ARDS among paediatric patients who are invasively mechanically ventilated, in part because mean airway pressure accounts for differences in baseline ventilator management, including PEEP strategy. 15 Neither the OI nor the OSI has been incorporated into official guidelines as a diagnostic criterion or riskstratification tool for ARDS in adults, but their prognostic validity has been studied in several settings.…”