Correlation and presentation of thyroid functional status with thyroid autoantibodies in long-term follow-up of autoimmune thyroiditis: A study of 116 cases

Chou, Kuei-Mei; Huang, Bie-Yui; Chen, Chih-Huang; Lin, Jen‐Der; Chiu, Sherry Yueh Hsia; Lee, Chin‐Chan

doi:10.1016/j.jfma.2013.05.017

Cited by 8 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found in our study that high TgAb titer, TSH, age, PLNs presence, and PLNs volume at the time of diagnosis were predictive of hypothyroidism development during the course of CAT. Similar to our results, a previous study has also reported that high titer of TgAb and advanced age could be a possible predictor of hypothyroidism in CAT (18).…”

Section: Discussionsupporting

confidence: 93%

Relationship of paratracheal lymph nodes with the progression of chronic autoimmune thyroiditis: 5-year follow-up results

Akbaba¹,

Berker²,

Işık³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: To examine changes in paratracheal lymph nodes (PLNs) and the relationship with the course of the disease in patients with chronic autoimmune thyroiditis (CAT) 5 years after diagnosis. Materials and methods:A total of 169 patients with newly diagnosed CAT and 53 healthy subjects were included in the study. All patients underwent ultrasonographic (US) examinations of the thyroid, paratracheal regions, and examined thyroid function tests. Eighty-four patients who were euthyroid at baseline and who were contacted 5 years after the diagnosis were reevaluated by US and thyroid function tests. Results:The PLNs frequency was significantly higher in the CAT group than the controls (75.1 % vs. 30.1 %, P < 0.001). Among the 84 patients who were euthyroid at the time of diagnosis and were contacted again after 5 years, 15 developed hypothyroidism. Initially, PLNs were present in all patients who developed hypothyroidism and were significantly higher than in those who remained euthyroid (respectively 100% vs. 68.7%, P = 0.009). PLN presence and PLN volume in patients who were euthyroid at baseline predicted hypothyroidism at the end of 5 years. Conclusion:PLNs may be used as an indicator of disease progression. In addition, patient age and baseline TSH levels are other factors that predict the development of hypothyroidism in time.

show abstract

Section: Discussionsupporting

confidence: 93%

Relationship of paratracheal lymph nodes with the progression of chronic autoimmune thyroiditis: 5-year follow-up results

Akbaba¹,

Berker²,

Işık³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Nonetheless, the prevalence of positive TSH-R-Abs among the patient populations in these studies is quite similar to what we found in our study. Some studies have not reported positive TSH-R-Abs in AIT, yet others have published surprisingly high percentages of TSH-R-Ab positivity (2,14). Our study raised the question as to how useful the information from measurements of TSH-R-Abs might be in Hashimoto's thyroiditis.…”

Section: Discussionmentioning

confidence: 70%

“…Secondly, the number of participants is modest which prevents us from finding the true prevalence as well as additional significant associations. Finally, only euthyroid and hypothyroid patients were selected, as the differentiation between thyrotoxicosis in Graves' disease or Hashimoto's thyroiditis with positive TSH-R-Abs is an ambitious task, even in the presence of cytological data (13,14).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…While a few surveys about euthyroid patients showed the prevalence rate between 9% and 23% (4,12). Two studies reported the prevalence of elevated antibody in 13.6% and 78.3% of hyperthyroid AIT patients, respectively (13,14). Some publications have described a negative correlation between TSH-R-Ab levels and the thyroid volume (12,(15)(16)(17) or the function (12,15,18), while others did not (9).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frequency Profile and Clinical Correlations of TSH Receptor Antibodies in Euthyroid and Hypothyroid Patients Having Autoimmune Thyroiditis

Mekova¹,

Boyanov²

2019

Turk J Endocrinol Metab

View full text Add to dashboard Cite

Objective: The current understanding regarding the clinical significance of TSH receptor antibodies in chronic autoimmune thyroiditis is controversial. The aim of this study was to examine the frequency of elevated TSH receptor antibodies in euthyroid and hypothyroid autoimmune thyroiditis. Furthermore, their associations with the levels of thyroid hormones and autoantibodies (thyroid peroxidase and thyroglobulin antibodies [TgAb]), and the thyroid volume were also investigated. Material and Methods: This cross-sectional study included recently diagnosed euthyroid (N=86) and hypothyroid (N=54) autoimmune thyroiditis patients along with the patients who were on levothyroxine replacement (N=66). The levels of TSH, free T4, free T3, TSH receptor antibodies, thyroid peroxidase, and thyroglobulin antibodies were measured using ECLIA (Roche Diagnostics, Switzerland). A 9 MHz transducer (Fukuda Corp., Japan) for thyroid ultrasound and a 14 MHz transducer (Ultrasonix Medical Corp., Canada) for Doppler ultrasound were employed. Statistical analyses were done with the help of IBM SPSS 19.0 software. Results: The elevated levels of TSH receptor antibodies were observed in 6.3% of the participants (12 females and 1 male) and exclusively in hypothyroid subjects, who were either untreated (7.4%) or on levothyroxine treatment (7.6%). The highest and the lowest prevalence of positive TSH receptor antibodies were seen in patients with positive thyroglobulin antibodies & negative thyroid peroxidase (17.6%) and positive thyroid peroxidase & negative thyroglobulin antibodies (3.3%), respectively. Higher levels of TSH receptor antibodies were associated with a shorter duration of the disease (22 vs. 36 months), lower titers of thyroglobulin antibodies (281.2 vs. 400.9 UI/L), decreased thyroid volumes (9.4 vs. 14.2 cm 3) and an increased prevalence of orbitopathy (23.1 vs. 4.1%). In the whole study population, TSH receptor antibodies levels were related to fT4 (linear R2=0.271, p=0.039), titers of thyroid peroxidase (quadratic, R2=0.048, p=0.034), and thyroid volume (compound R2=0.041, p=0.011). However, in the TSH receptor antibodies positive patients, the correlation was seen only with the levels of thyroid peroxidase (compound R2=0.503, p=0.032). Conclusion: TSH receptor antibodies positivity cannot be considered negligible in Hashimoto's thyroiditis. The elevated levels of TSH receptor antibodies might result in a predisposition to a more unstable thyroid function, lower thyroid volumes, specific profiles of thyroid peroxidase, and thyroglobulin antibodies and a higher prevalence of thyroid-associated ophthalmopathy.

show abstract

“…Prummel et al [24] found that positive rate of TPOAb in population with normal thyroid function may reach 12% to 26%, often accompanied by TGAb positive, of which positive rates were similar [25], and patients with high titers of TGAb were more likely to develop hypothyroidism [26]. In this study, the positive rates of TPOAb, TGAb and simultaneous detection rate of TPOAb and TgAb were 39.92% (99/248), 39.11% (97/248) and 31.45% (78/248) respectively in the patients with thyroid dysfunction, which is consistent with the results reported by Zhao Rencheng [27], subclinical hypothyroidism patients with autoantibody positive accounting for 1/3 to 1/2, indicating that thyroid autoantibody involved in the pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine

Hou¹,

Zhaoxin²,

Wang³

et al. 2017

SJPH

View full text Add to dashboard Cite

Abstract:In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.

show abstract

Correlation and presentation of thyroid functional status with thyroid autoantibodies in long-term follow-up of autoimmune thyroiditis: A study of 116 cases

Abstract: In our study, most patients were HT; this may be because of the early diagnosis and treatment of AT in our clinic. Although antithyroperoxidase antibody (TPOAb) is a hallmark antibody of HT, it cannot predict the initial presentation and clinical outcome.

Cited by 8 publications

References 25 publications

Relationship of paratracheal lymph nodes with the progression of chronic autoimmune thyroiditis: 5-year follow-up results

Relationship of paratracheal lymph nodes with the progression of chronic autoimmune thyroiditis: 5-year follow-up results

Frequency Profile and Clinical Correlations of TSH Receptor Antibodies in Euthyroid and Hypothyroid Patients Having Autoimmune Thyroiditis

Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine

Contact Info

Product

Resources

About