Correlation between Bacterial Wound Colonization and Skin-Graft Loss in Burn Patients

Wellkamp, Lukas; Obed, Doha; Enechukwu, Anieto Onochie Matthias; Bingoel, Alperen S.; Dastagir, Khaled; Vogt, Peter M.

doi:10.1093/jbcr/irac129

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…If this keeps happening, the wound can become chronic and stop healing. [43][44][45][46] Therefore, it is vital to remove the contaminating microbes during the inflammation phase. In recent decades, numerous antibacterial agents have been developed and the existence of antibacterial materials could be classified into the following types: antibiotics, antibacterial nanoparticles and others.…”

Section: Factors Affecting Wound Healingmentioning

confidence: 99%

“…The presence of Gram-positive bacteria is notable in the early stages of infection, whereas Gram-negative bacteria appear in the stably established wounds. 43,45,46 According to the findings of recent clinical trials, using contemporary wound dressings may be the most convenient, affordable, and successful way to treat unhealed wounds. As a result, wound dressing development has a lot of potential.…”

Section: Antibacterial Propertymentioning

confidence: 99%

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Animal tissue-derived biomaterials for promoting wound healing

Cao

Lin

et al. 2023

Mater. Horiz.

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Section: Factors Affecting Wound Healingmentioning

confidence: 99%

Section: Antibacterial Propertymentioning

confidence: 99%

Animal tissue-derived biomaterials for promoting wound healing

Cao

Lin

et al. 2023

Mater. Horiz.

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Poison Turned Panacea: Arsenic Trioxide Loaded Hydrogel for Inhibiting Scar Formation in Wound Healing

Xu,

Wang,

Han

et al. 2024

ACS Biomater. Sci. Eng.

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Without intervention, the natural wound healing process can often result in scarring, which can have detrimental effects on both the physical and mental well-being of patients. Therefore, it is crucial to develop biomaterials that can promote healing without scarring. Regulating the Yes-associated protein-1/PDZ-binding motif (YAP/TAZ) signaling pathway is possible to reduce excessive fibrosis of fibroblasts and proliferation of vascular endothelial cells, ultimately impacting scar formation. Arsenic trioxide (ATO), an ancient drug with medicinal and toxic properties, has shown promise in regulating this pathway. An ATO-loaded hydrogel dressing (ATO@CS/SA) was created to facilitate scarless wound healing, utilizing chitosan (CS) and sodium alginate (SA) to prevent direct contact of ATO with the wound tissue and minimize potential side effects. In vitro studies demonstrated that low concentrations of ATO did not impact cell viability and even promoted proliferation and migration. Co-culturing the hydrogel with fibroblasts and vascular endothelial cells led to decreased expression levels of YAP and TAZ. Animal studies over a 90-day period revealed significant inhibition of scar formation with this system. Histological experiments further confirmed that the decreased expression of YAP and TAZ was responsible for this outcome. In conclusion, when administered at the appropriate dose, ATO can be repurposed from a traditional poison to a therapeutic agent, effectively suppressing excessive cell fibrosis and blood vessel proliferation and offering a novel approach to scar-free treatment.

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Update burn surgery: overview of current multidisciplinary treatment concepts

Schlottmann,

Lorbeer

2024

Innovative Surgical Sciences

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The treatment of severe burn injuries is an essential part of plastic-reconstructive surgery. Severe burned patients are treated in burn centers, which have highly specialized technical and personnel equipment. In addition to clear recommendations for prehospital management, intensive care therapy is usually required for extensive burn wounds. Shock therapy in burns primarily involves balanced fluid resuscitation according to hemodynamic monitoring, vasopressor support, pain management, temperature regulation, oxygen therapy, and comprehensive supportive care to stabilize the patient’s condition. Surgical treatment is still based on wound debridement and the gold standard of autologous split-thickness skin grafting. Besides skin transplantation, surgical management of burns may also involve the application of various topical therapies to promote wound healing, reduce pain, and prevent infection. These therapies may include antimicrobial dressings, skin substitutes, growth factors, or specialized wound care products. Once the acute treatment has been completed, multidisciplinary rehabilitation treatment takes place, which begins in the acute hospital and continues in the outpatient and inpatient rehabilitation areas. Surgical treatment of the secondary complications of burns and scars is also an important component of burn care. Comprehensive knowledge of the various components and players involved in the care of severely burned patients is, therefore, required in order to achieve the best possible outcome for the patient.

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Correlation between Bacterial Wound Colonization and Skin-Graft Loss in Burn Patients

Cited by 3 publications

References 29 publications

Animal tissue-derived biomaterials for promoting wound healing

Animal tissue-derived biomaterials for promoting wound healing

Poison Turned Panacea: Arsenic Trioxide Loaded Hydrogel for Inhibiting Scar Formation in Wound Healing

Update burn surgery: overview of current multidisciplinary treatment concepts

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