Correlation between Bactericidal Activity of Fosfomycin Trometamol
in an in vitro Model of the Urinary Bladder and Susceptibility Testing

C, Pinasi; Albini, E.; Marca, G

doi:10.1159/000472868

Cited by 7 publications

(5 citation statements)

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“…The drug has a favourable pharmacokinetic pattern, it shows antibacterial activity against uropathogens like Escherichia coil (MICS0 < 2 rag/I), Proteus mirabilis (MRC50 2-8 mg/I) and Staphylococcus saprophyticus (MRC50 32-128 mg/I) [13], and it penetrates into leucocytes and shows no cross-resistance with other antibiotics because of its unique chemical structure [14].…”

Section: -I I]mentioning

confidence: 99%

Fosfomycin trometamol in a single dose versus seven days nitrofurantoin in the treatment of acute uncomplicated urinary tract infections in women

Pienbroek

Hermans

et al. 1993

Pharm World Sci

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In general practice acute uncomplicated urinary tract infections in women are treated with different courses of antibiotics. In this study the efficacy and tolerability of a single dose of 3 g fosfomycin trometamol and the conventional treatment with nitrofurantoin 50 mg four times daily for seven days were compared. In a randomized, double-blind, double-dummy trial in 31 general practices in the Netherlands 231 patients with symptoms of acute dysuria, stranguria and/or urinary frequency received treatment. Evaluation was based on resolution of symptoms, dipslide results and side-effects at 4, 9 and 42 days after starting the treatment. The clinical cure rates and bacteriological cure rates were not significantly different between the treatment groups. Side-effects were reported at day 4 by 43% of the women receiving single-dose treatment, compared with 25% of the women in the seven-day treatment group, a significant difference. At day 9 the groups did not significantly differ in the number of patients with side-effects. Almost all side-effects were mild and gastro-intestinal complaints were reported most. Taking into account the convenience of taking a single dose we conclude that fosfomycin trometamol is a reasonable alternative to 7 days nitrofurantoin 50 mg four times a day in the treatment of women with symptoms of acute uncomplicated urinary tract infections in general practice.

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Section: -I I]mentioning

confidence: 99%

Fosfomycin trometamol in a single dose versus seven days nitrofurantoin in the treatment of acute uncomplicated urinary tract infections in women

Pienbroek

Hermans

et al. 1993

Pharm World Sci

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“…Our previous study showed a highly significant correlation between bactericidal activity data obtained in this in vitro model and clinical efficacy of antibiotics [4]. Similar pharmacokinetics simulation models have also been used to estimate the optimum dosage of antibiotics [5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Effect of Levofloxacin on Strains with Equal Susceptibility in anin vitro Urinary Bladder Model

Takahashi

Sano²,

Nishimura³

et al. 1998

Chemotherapy

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The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10⁷ CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simulated to its clinically achievable urinary levels at the recommended dosage (100 mg 3 times daily). An isolate of P. aeruginosa for which the MIC of LVFX was 16 µg/ml was completely eradicated after 10 h of exposure to LVFX. On the other hand, 40 h of exposure to LVFX were required for complete eradication of an isolate of E. faecalis with equal susceptibility, although the bacterial count was rapidly reduced to 10² CFU/ml in the early phase of the exposure. It was concluded that LVFX exerts a more potent bactericidal effect on P. aeruginosa than on E. faecalis despite a similar susceptibility of these organisms to LVFX.

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“…All of the equipment was assembled to simulate the human urinary bladder system. Some of the selected literature established in vitro bladder models based on the same models or with some modifications [two bladder models (13,15) were modified from the model reported by Abbott et al (21); eight bladder models (16,17,19,30,32,33,35,38) were modified from the model reported by Stickler et al (49); two bladder models (32,39) were modified from the model reported by Gaonkar et al (43); one bladder model (28) was modified from the model reported by Fu et al (36); two bladder models (31,34) was modified from the model reported by Andersen et al (37); one bladder model (45) was modified from the model reported by Stickler et al (55); one bladder model (48) was modified from the model reported by Getliffe et al (59); six bladder models (19,41,(50)(51)(52)(53) were modified from the model reported by Stickler et al (58); one bladder model ( 62) was modified from the model reported by Stickler et al (64); 11 bladder models (63,(65)(66)(67)(68)(69)(70)72,73,…”

Section: Model Construction and Analysismentioning

confidence: 99%

“…Twenty-five studies reported different culture mediums, such as tryptone liquid culture (36) and MHB culture m e d i u m ( 1 3-1 5 , 2 1 , 5 6 , 6 1 , 6 3 , 6 6 -7 2 , 7 4 , 7 5 , 7 7 -8 4 ) . M e a n w h i l e , 1 7 s t u d i e s r e p o r t e d h u m a n u r i n e (20,24,25,28,29,33,46,48,49,57,58,61,65,(71)(72)(73)76), and the remaining 32 studies reported artificial urine. Undoubtedly, urine that could be used as a culture medium is the closest simulation of the human environment.…”

Section: Infection Mediamentioning

confidence: 99%

“…, latex(39,43,50,58,60), Foley catheter(22,47,48,53,56,59) with no statement of the specific materials, agar plates(13,15,57,62,65,68,70,71,73), and silicone(14,16-18,24- 30,32,33-38,40,41,49,51,52,54,55). The other eight studies(20,23,31,(43)(44)(45)58,60) also reported some materials, while the remaining 17 studies(61,63,65,67,69,72,74,75,(78)(79)(80)(81)(82)(83)(84)(85)(86) did not explicitly report infection vectors.…”

mentioning

confidence: 99%

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In vitro dynamic bladder models for studying urinary tract infections: a narrative review

Xiong¹,

Xie²,

Liu³

2021

Ann Palliat Med

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Experimental models of the bladder are key to studying the pathogenic mechanism of catheterrelated bacterial biofilm infection. Although numerous studies have reported multiple models, these model designs were heterogeneous. This study aimed to review the status quo and explore the problems associated with in vitro dynamic bladder models for studying urinary tract infections (UTIs). The PubMed and SinoMed databases were searched from their inception to February 2020. Studies regarding in vitro bladder models related to UTIs were reviewed based on a bibliometric evaluation of their basic characteristics and model analysis. A total of 74 papers and 44 bladder models were included in this study. The results were as follows: (I) urine transmission devices: 10 studies applied the gravity effect of culture media, while the others used peristaltic pumps, and 11 of them combined stirring or rotating forces. The flow rates in all studies ranged from 15 µL/min to 50 mL/min. (II) Bladder model: two studies reported on simulating the bladder using plastic bags, while the others reported on glass cylinders or fermenters with a capacity of 200 to 700 mL. E. coli and P. mirabilis were the main bacterial strains. (III) Infection carrier: six studies reported planktonic bacteria as their infection carrier, while 45 studies reported silica gel, rubber, polyurethane, silicone, polytetrafluoroethylene, or perfusion bag. (IV) Infection medium: 25 studies reported the culture medium. Thirty-two studies reported artificial urine, while 17 studies reported human urine. (V) Research analysis: 45 studies investigated the bacterial biofilm formation in the bladder model. Thirty-six studies compared the effects of various drug coatings, diverse material surfaces, or different materials. Only five studies compared distinct bladder models. The included studies' main defects were the single simulation of bladder urodynamics, divers parameter settings, and non-standard experimental modeling. Our analysis showed for the first time that in vitro dynamic bladder models could provide new ideas for exploring the mechanism and prevention of bacterial biofilm infection in urinary implanted biomaterials. Due to the limitations of the included studies, more high-quality studies are needed to verify the conclusions above further.

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Correlation between Bactericidal Activity of Fosfomycin Trometamol in an in vitro Model of the Urinary Bladder and Susceptibility Testing

Cited by 7 publications

References 0 publications

Fosfomycin trometamol in a single dose versus seven days nitrofurantoin in the treatment of acute uncomplicated urinary tract infections in women

Fosfomycin trometamol in a single dose versus seven days nitrofurantoin in the treatment of acute uncomplicated urinary tract infections in women

Bactericidal Effect of Levofloxacin on Strains with Equal Susceptibility in anin vitro Urinary Bladder Model

In vitro dynamic bladder models for studying urinary tract infections: a narrative review

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