Correlation between benign prostatic hyperplasia and inflammation

Abstract

Although the pathogenesis of BPH is not yet fully understood and several mechanisms seem to be involved in the development and progression, recent studies strongly suggest that BPH is an immune inflammatory disease. The T-cell activity and associated autoimmune reaction seem to induce epithelial and stromal cell proliferation. Further understanding of the role of inflammation in BPH and clinical detection of this inflammation will expand the understanding of BPH pathogenesis and its histologic and clinical progression, allow risk stratification for patients presenting with BPH-related LUTS, and suggest novel treatment strategies.

Flurbiprofen alone and in combination with alfuzosin for the management of lower urinary tract symptoms

“…In an older study, Kohnen et al reported the incidence of inflammation as high as 98.1% in surgically resected hyperplastic prostates [14]. Not only in the pathogenesis of BPH, but also in the progression of the disease, role of prostatic inflammation is growingly supported by clinical and experimental studies [9,10,15,16]. Furthermore, prostatic inflammation has been found to be associated with higher IPSS and symptom progression in BPH patients by data analysis of the large clinical study "reduction by dutasteride of prostate cancer events" also known as REDUCE [11].…”

“…Recent studies strongly suggest that BPH is an immune inflammatory disease [7]. Cytokines produced by inflammatory cells are believed to play essential roles in the development and maintenance of prostate growth by increasing growth factor production and angiogenesis [8,9,10]. Nickel et al demonstrated Citation: Gokkaya CS, Aktas BK, Ozden C, Bulut S, Karabakan M, Erkmen AE, Memis A. Flurbiprofen alone and in combination with alfuzosin for the management of lower urinary tract symptoms.…”

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

“…Studies have suggested close links among certain infections of the prostate, chronic inflammation, and the development of inflammation-associated prostatic diseases (5)(6)(7)(8)(9)(10). It has been proposed that certain infections of the prostate contribute to the development of chronic inflammation and regenerative "risk factor" lesions, referred to as proliferative inflammatory atrophy, contribute to the development of prostate cancer (3)(4)(5).…”

Histopathologic Characterization of Prostate Diseases in Madinah, Saudi Arabia

“…Although BPH is predominantly attributed to aging, genetic factors and hormonal disturbances (Nicholson and Ricke, 2011), a possible role of obesity, diet and life style is also under investigation (Tewari et al, 2012;Goluch-Koniuszy et al, 2013). Similarly the significance of chronic inflammation in pathogenesis of BPH has recently emerged (Fibbi et al, 2010) and emphasized by recent publications (Vral et al, 2012;Bostanci et al, 2013;of cancer death (Brawley, 2012a). Screening programs have increased risk of diagnosis among younger men in their 40s and 50s (Brawley, 2012b).…”