Correlation between biochemical markers of endothelial dysfunction, free radical oxidation and morphometric parameters of macular retina in pregnant women with preeclampsia

Kolenko, О.V.; Pomytkina, N.V.; Sorokin, Е.L.; Bloshchinskaya, I. A.; Pashentcev, Ya. E.

doi:10.17116/oftalma201913502139

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Як відомо з результатів останніх досліджень, SARS-CoV-2 може безпосередньо фіксуватись до ендотеліальних клітин та індукувати дисфункцію ендотелію судин, внаслідок чого виникає посилення процесів перекисного окиснення ліпідів, порушення мікроциркуляції, підвищення системного і внутрішньониркового тиску, гіпоксія [15,16]. В свою чергу маркерами ендотеліальної дисфункції вважають зниження ендотеліального синтезу оксиду азоту (NO), підвищення рівнів ендотеліну-1, фактора фон Віллебранда, інгібітора активатора плазміногену, гомоцистеїну, тромбомодуліну, розчинної молекули судинної міжклітинної адгезії B1, С-реактивного білка, мікроальбумінурію [17,18].…”

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An integrated approach to the treatment of pelvic pain associated with adenomyosis

Татарчук

Калугина

Danylova

et al. 2021

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Dysmenorrhoea and intermenstrual pelvic pain are the most common symptoms of clinical manifestations of adenomyosis, which significantly impair the quality of women’s life. Adequate and long-term pain correction and alternative therapeutic approaches became extremely important for patients with adenomyosis during the COVID-19 pandemic. Research objective: to examine the clinical efficacy of nitric oxide donor (L-arginine) in the complex treatment of pelvic pain syndrome associated with adenomyosis.Materials and methods. The study included 63 women diagnosed with adenomyosis. Patients were divided into 2 groups by simple randomization: I (D) group (n = 31) received dydrogesterone 30 mg from 5 to 25 days of the menstrual cycle, II (D+T) group (n = 32) in addition to dydrogesterone received a nitric oxide donor L-arginine (Тivortin) according to the scheme. Pelvic pain was assessed before treatment with a Visual Analogue Scale and a McGill Pain Questionnaire, and an assessment of the overall pain impact on women's well-being was based on the SF-36 Health Status Survey. The effectiveness of pelvic pain therapy was assessed after the first and third months of treatment, as well as three months after the end of therapy with the above methods.Results. Researchers achieved a therapeutic effect in the treatment of chronic pelvic pain in both study groups, but in group II (D + T) after 3 months of treatment there was a significant reduction in pelvic pain, while patients of the standard therapy group have prolonged progestogen intake. There was a further improvement in the clinical condition in group I (D) after 6 months of follow-up, as well as no recurrence of pain in group II (D + T).Conclusions. The results of study demonstrate a significant effect of Tivortin as part of complex therapy on the rate of achievement and duration of therapeutic effect in the treatment of pelvic pain associated with adenomyosis.

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An integrated approach to the treatment of pelvic pain associated with adenomyosis

Татарчук

Калугина

Danylova

et al. 2021

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Maternal blood proteomics during relapse of early preeclampsia

Nikolaeva,

Terekhina,

Momot

2023

Akušerstvo, ginekologiâ i reprodukciâ

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Aim: to study the contribution of maternal blood endothelial proteins to developing relapse of early preeclampsia (ePE).Materials and Methods. A proteomic analysis of the peripheral blood of 137 pregnant women was performed. Clinically, three groups were identified at the end of pregnancy: control (n = 40), patients with favorable course of the current and previous pregnancy; comparison group (n = 59) – patients with a history of еPE episode, but favorable course of ongoing pregnancy, and main group (n = 38) – patients with еPE relapse. Biologically active substances evidencing about impaired endothelial function were subject to dynamic monitoring (11–13, 19–21 and 27–28 weeks): activity of endothelin-1 (ET-1) and metalloproteinase ADAMTS-13, von Willebrand factor (vWF) level and homocysteine (HC)concentration. The ADAMTS-13/vWF ratio was evaluated separately.Results. For patients with recurrent еPE, a significant increase in ET-1 is characteristic at all stages of gestation: 0.92; 1.07 and 1.36 pmol/ml vs. 0.29; 0.33 and 0.29 pmol/ml in the control group (p < 0.0001 at all points). Regardless of pregnancy outcome, increasing gestational age was paralleled with elevating vWF level, however, upon еPE relapse, this parameter (Me = 343 IU) is significantly higher (p < 0.0001) than in control group (Me = 260 IU). In all groups, there was a significant decrease in ADAMTS-13 activity, whereas in main group ADAMTS-13 activity at first time point was minimal – 63.4 % (p = 0.0007 relative to control group). With regard to ADAMTS-13/vWF axis in relapsed еPE, significant differences were found compared with control group both at 11–13 weeks (0.32 versus 0.52; p < 0.0001) and at 27–28 weeks (0. 15 versus 0.22; p < 0.0001) pregnancy. The HC concentration declines with gestational age, but at first time point patients from main group had it (Me = 8.0 µmol/l) at significantly higher level than in control group (Me = 5.9 µmol/l; p < 0.00010).Conclusion. At gestational age of 11–13 weeks, all analyzed biomarkers contribute to developing еPE relapse accounting for an overall impact of 62.3 % of developing ePE risk. During pregnancy at 19–21 weeks, an imbalance in the ADAMTS-13/vWF along with elevated ET-1 levels determine the risk of disease relapse in 65.6 % of cases. It was found that at a gestational age of 27–28 weeks, the associated shift in ET-1, vWF and ADAMTS-13 magnitude accounts for 67.9 % of risk for disease relapse.

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Correlation between biochemical markers of endothelial dysfunction, free radical oxidation and morphometric parameters of macular retina in pregnant women with preeclampsia

Cited by 2 publications

References 7 publications

An integrated approach to the treatment of pelvic pain associated with adenomyosis

An integrated approach to the treatment of pelvic pain associated with adenomyosis

Maternal blood proteomics during relapse of early preeclampsia

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