2020
DOI: 10.1155/2020/8078412
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Correlation between C-reactive Protein with Malondialdehyde in Systemic Lupus Erythematosus Patients

Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus … Show more

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Cited by 6 publications
(7 citation statements)
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“…The increase of anti-dsDNA levels in SLE is caused by the function of Th2 cells that increased more than normal, leading to the overreactivity of B cell, thus producing autoantibody and causing tissue damage (Atik et al, 2020). In this study, the anti-dsDNA levels in PIL mice have been proven to increase due to pristane injection.…”
Section: The Effect Of Ns On the Level Of Anti-dsdna In Pil Micementioning
confidence: 71%
See 1 more Smart Citation
“…The increase of anti-dsDNA levels in SLE is caused by the function of Th2 cells that increased more than normal, leading to the overreactivity of B cell, thus producing autoantibody and causing tissue damage (Atik et al, 2020). In this study, the anti-dsDNA levels in PIL mice have been proven to increase due to pristane injection.…”
Section: The Effect Of Ns On the Level Of Anti-dsdna In Pil Micementioning
confidence: 71%
“…The latest journal mentioned that the SLE cannot be cured because the present treatment is still only targeting symptomatic relief. It is due to the etiology of this disease which is still hard to be discovered; thus, the specific therapy is also still hard to be determined (Atik et al, 2020). The three major common etiologies of SLE are genetic, hormonal, and environmental factors (Finzel et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Female was typically predisposed to developed SLE as shown in this study with normally affects 30-year-old female and has 5-year disease duration, this data is similar with previous studies in our country and anywhere else. 12,22 Dysregulation of immune responses in SLE patients is caused by the autoimmunity process and immunosuppressant therapy. Moreover, fluctuating disease activity may exacerbate this condition.…”
Section: Discussionmentioning
confidence: 99%
“…Tissue samples and ELISA kit standards were labeled with biotin-labeled antibodies, and 3,3’,5,5’ tetramethylbenzidine (TMB) substrates were added. A spectrophotometer was used to measure the optical density of the samples at a wavelength of 450 nm [ 16 ].…”
Section: Methodsmentioning
confidence: 99%