Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma

Abstract

Purpose To investigate the correlation between changes in lamina cribrosa (LC) structure using enhanced depth imaging (EDI) and severity of visual field (VF) affection in primary open-angle glaucoma (POAG). Patients and Methods This prospective cross-sectional study was carried out on 52 glaucomatous eyes of 28 POAG patients who attended Tanta University Eye Hospital and 40 normal eyes of 20 age-matched normal subjects from April 2020 to March 2021. POAG patients were classified according to the modified Hodapp–Anderson–Parrish grading scale based on the MD of the standard automated perimetry (SAP) visual field into two groups: group (1) – mild-to-moderate POAG patients (MD ≤ 12 dB), group (2) – severe POAG patients (MD ≥ 12 dB) and the third group included normal (control) age- and gender-matched individuals. Results There was no statistically significant difference between the three groups regarding lamina cribrosa thickness nor lamina cribrosa area and there was no statistically significant correlation between MD and LC thickness, LC area (P-value=0.395 and 0.644). There was a statistically significant correlation between MD and anterior lamina cribrosa surface depth (P-value=0.002) and there was a statistically significant positive correlation between MD and prelaminar neural tissue (PLNT) thickness and prelaminar neural tissue (PLNT) area (P-value= 0.023 and <0.001, respectively). Conclusion EDI-OCT is a useful biomarker of structural changes in ONH and LC, and we recommended it to be a part of the routine monitoring of patients with POAG.

Temporal Protrusion of the Optic Disc Implicated in Central Visual Field Abnormalities in High Myopia: Two Case Reports

“…Considering that the RNFL between the optic disc and macula is referred to as the PMB and is responsible for central vision [ 23 ], it is reasonable to assume that the fLCD between the optic disc and macula implicates central VF abnormalities. Furthermore, the prelaminar tissue’s thickness in our cases was notably thinner compared to healthy individuals, potentially resulting from RNFL thinning secondary to the development of fLCD, affecting the central VF [ 24 , 25 ]. The large, unusual morphology of the optic disc protruding toward the macula may be a crucial risk factor for fLCD and central VF disturbance in highly myopic eyes.…”

Khảo sát tương quan giữa thông số lá sàng với độ dày lớp sợi thần kinh và tổn thương thị trường ở bệnh nhân glôcôm góc mở nguyên phát

“…Trong đó, độ dày lá sàng có tương quan thuận trung bình với chỉ số MD (Spearman; r = 0,486, p < 0,001). Đối với thông số độ sâu lá sàng, Basty và Fayed đồng ý với nghiên cứu của chúng tôi rằng có một mối tương quan nghịch đáng kể giữa độ sâu lá sàng và chỉ số MD [10], [13]. Martha Kim nhận thấy mối tương quan có ý nghĩa giữa mức độ nghiêm trọng của bệnh glôcôm khi được đo bằng chỉ số MD và độ sâu lá sàng.…”

Comparative Evaluation of Lamina Cribrosa Anatomical Parameters with Retinal Nerve Fiber Layer Thickness Defects In Primary Open-angle Glaucoma Cases And Controls

“…The onset of LC morphological aberrations occurs way before the initiation of GON, hence its imaging and observation can be regarded as an early sign of glaucomatous damage. 5,6 Exploration of anatomical parameters of LC is advantageous and promises to play a vital role in management of glaucoma. LC can be visualized by non-invasive imaging using spectral domain ocular coherence tomography (SD-OCT) with EDI.…”