Correlation between compression, tensile and tearing tests on healthy and calcified aortic tissues

Walraevens, Joris; Willaert, Bert; Win, Gunter De; Ranftl, Andrea; Schutter, Joris De; Sloten, Jos Vander

doi:10.1016/j.medengphy.2008.01.006

Cited by 41 publications

(32 citation statements)

References 33 publications

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“…[1][2][3] Current methods for the in vivo characterization of animal tissue include two widely used techniques: palpation and elastographic imaging. Palpation is when an individual feels the tissue for regions of either increased or decreased stiffness.…”

Section: Introductionmentioning

confidence: 99%

Cavitation rheology of the vitreous: mechanical properties of biological tissue

2010

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We demonstrate the importance of measuring the mechanical properties of biological tissue in vivo by quantifying the mechanical properties of bovine vitreous both in its native state and upon removal from the eye. The mechanical properties are determined by the cavitation rheology technique developed in our labs to determine the linear modulus. This technique involves inducing a cavitation event at the tip of a syringe that is located at an arbitrary location within the vitreous sample. The pressure at which the cavitation event occurs can be directly related to the modulus. We show that the modulus decreases upon removal of the vitreous from the ocular cavity and decreases still further when the vitreous cortex, the thin membrane that surrounds the vitreous, is removed. This study has important implications for both diagnostic science of diseased tissue and developmental biology in studying tissue properties with age.

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Section: Introductionmentioning

confidence: 99%

Cavitation rheology of the vitreous: mechanical properties of biological tissue

2010

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“…Therefore, compressive tests are widely used to determine the mechanical behavior of atherosclerotic plaque tissues. [29,30] To simulate the compressive mechanical properties of human arteries, we first measured the storage modulus (E 0 ) of healthy aortic tissue. Using dynamic mechanical analysis (DMA), we found a relatively frequency independent E' for healthy arteries that vary from E 0 % 0.1 to E 0 % 2.5 MPa (Figure 3a).…”

Section: Resultsmentioning

confidence: 99%

Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque

et al. 2016

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This paper demonstrates progress of fabricating artificial arteries (phantoms) that mimic plaque buildup. Hydrogel lumens are molded using tough polyacrylamide with regions selectively mineralized with calcium phosphate. By tuning the degree of mineralization such as calcium concentration ([Ca 2þ ], 0.4-2 M), and crystallization time (t c , 1-4 weeks), the authors control the extent of lumen occlusion. These occluded lumens significantly reduce pressure (DP % 7.79 kPa) during fluid flow compared to the non-calcified lumens (DP % 1.24 kPa). Additionally, image, chemical analysis, and compressive mechanical tests are performed to determine the effect of synthesis conditions on the composite's mechanical properties. For comparison to real arteries, the authors also present dynamic mechanical analysis of human aortic tissue.

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“…15) It has been known that calcified plaque is weaker in tensile stress than in compressive stress. 20) In short, a tensile stress on the outside of circumferential calcification by the Scoreflex balloon catheter may create the crack of calcified plaque, which was unresponsive to the conventional balloon catheter. We have also reported that the Scoreflex balloon enabled to crack the circumferential calcification on the outside of a previously underexpanded sirolimus-eluting stent that was unresponsive to highpressure inflation using a conventional balloon after aggressive RA.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Inflation Technique Using a Scoring Balloon for Severe Calcified Lesion

et al. 2017

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SummaryPercutaneous coronary intervention for the treatment of a severe calcified lesion is still one of the most technically challenging areas of interventional cardiology. Calcified lesions are a cause of stent underexpansion, which significantly increases the subsequent risks of in-stent restenosis and thrombosis, even when drug-eluting stents are used. In this report, we describe the usefulness of prolonged inflations using a scoring balloon catheter (Scoreflex) for severe calcified lesions. Prolonged inflation using a scoring balloon enables an adequate dilation for treatment of a severe calcified plaque that was unresponsive to conventional technique with or without rotational atherectomy.(Int Heart J 2017; 58: 982-987) Key words: Calcified plaque and indentation, Scoreflex T he use of drug-eluting stents (DESs) reduces the risks of repeat revascularization without an increase in death and myocardial infarction compared with the standard bare-metal stents. However, the risk of in-stent restenosis and stent thrombosis (ST) after DES implantation still remains.Percutaneous coronary intervention (PCI) for the treatment of a severe calcified lesion is still one of the most technically challenging areas of interventional cardiology.

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Correlation between compression, tensile and tearing tests on healthy and calcified aortic tissues

Cited by 41 publications

References 33 publications

Cavitation rheology of the vitreous: mechanical properties of biological tissue

Cavitation rheology of the vitreous: mechanical properties of biological tissue

Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque

Prolonged Inflation Technique Using a Scoring Balloon for Severe Calcified Lesion

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