Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma

Golubović, Mileta; Asanin, Bogdan; Jelovac, Drago; Petrović, Milan; Antunović, Marija

doi:10.2298/vsp1001019g

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Tumour size determines whether tumour will develop into high or low risk group by virtue of recurrence and regional metastasis of lip SCC. As per the review of literature, the possibility for regional metastases increases 2.8 folds with the increase of lip SCC size over 2 cm in diameter (Golubović et al, 2010).…”

Section: Discussionmentioning

confidence: 83%

Invasive Lower Lip Squamous Cell Carcinoma Mimicking Traumatic Fibroma: Case Report

Hange¹

2020

JSRMBS

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Carcinoma of lip develops due to formation of malignant cells in the lips and it is the most common site for squamous cell carcinoma (SCC) in the head and neck region. Oral cavity is among top five leading sites of cancer, regardless of gender distribution across India. Squamous cell carcinoma of lip occurs at myriad locations along the upper or lower lip or commissure of lip, but majority (80% to 95%) of cases are seen on the lower lip region. Majority of oral cavity carcinoma cases (> 90%) are seen in patients above the age of 45, having a male predilection in distribution. Lesions that includes up to one third of the lower lip are typically treated with V-type or W-type excisions. Lesions affecting between one to two thirds of the lower lip are typically treated by regional flaps of Abbe or Estlander. Larger lesions involving more than two thirds of the lower lip are treated with Bernard flap for middle lesions and nasolabial transpositional flap for lateral lesions. Alternatively, definitive radiotherapy can be used for local control of early-stage epithelial malignancies of the lips such as basal cell and squamous cell carcinomas, but usually reserved for selected situations, also side effects of irradiation limits its use. Local resection along with elective SOHND is mandatory for long term survival rate and to avoid substantial worse prognosis. This case report describes an unusual presentation of carcinoma of lip mimicking benign soft tissue swelling.

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Section: Discussionmentioning

confidence: 83%

Invasive Lower Lip Squamous Cell Carcinoma Mimicking Traumatic Fibroma: Case Report

Hange¹

2020

JSRMBS

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“…It is a factor that allows the distribution of oral cancer patients in groups with a higher or lower risk of recurrence and/or metastatic disease. According to the literature, the risk for regional metastases increases 2.8 times with increasing of lip SCC size over 2 cm in diameter ( 4 ). The authors present the case of a patient with squamous cell carcinoma of the upper lip pointing out the importance of early detection and complete surgical removal of such tumors concerning the fact that this case suggests a higher prognostic significance of the size of the upper lip cancer, as well as the infiltration in tumor-surrounding tissue, mainly the perineural and perivascular spread, than the degree of its histological differentiation for the development of metastatic changes in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…According to a comprehensive study from Israel, SCC is a dominant type of lip cancer, mostly among men aged over 53 and exposed to UV-radiation ( 3 ). In a retrospective–prospective study, epidemiological data showed that in almost half (45%) of the oral cavity SCC cases among the population in Montenegro, both lower and upper lip were affected ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Unusual Growth of Upper Lip Squamous Cell Carcinoma: A Case Report

Stojanović¹,

Jovanović²,

Vuckovic³

2015

Iran Red Crescent Med J

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Introduction:Squamous cell carcinoma is the most common type of lip and oral cavity cancers. In majority of cases it follows quite common course, and after the surgery it does not produce any harm. This case presents unusual and unexpected growth of upper lip squamous cell carcinoma with severe cosmetic problems, and possible health threats.Case Presentation:A 46-year-old woman noticed on her upper lip “a spot, the size of a wheat grain”, which grew rapidly and reached the size of 0.6 cm during a two-week period. The lesion was red, hard and painful, attached to the skin. It was surgically removed, and primary histopathological finding was follicular keratosis. Recurrent tumor appeared seven days after the operation, with the extreme swelling of the upper lip. The patient was sent to a tertiary hospital, where fungal or bacterial infection was excluded. The change on the patient’s upper lip reached the size of 5 × 2 cm, as soft, reddish nodular tumor. Squamous cell carcinoma was diagnosed after the histopathological audit. With the second surgical intervention the tumor was removed and the defect reconstructed.Conclusions:Prognosis of this type of tumor, apart from its size and differentiation level, depends on infiltration in tumor-surrounding tissue, perineural and perivascular spread. Therefore, it is always necessary to analyze the removed skin especially on margins.

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“…Basic morphological features for estimation of the malignancy level include the histological grade, nuclear grade, mitotic index and nucleocytoplasmic ratio [37][38][39][40]. These parameters are significantly correlated with the degree of tumor infiltration of marginal resection tissue [41,42]. Studies have shown differences in the survival rate of patients with OSC [4][5][6].…”

Section: Markermentioning

confidence: 99%

Expression of PCNA, CD-31 and HER-2 in Serbian patients with oral squamous cell carcinoma

Loncarevic

Brajković

Gardasevic

et al. 2019

ARCH BIOL SCI BELGRA

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Several studies have investigated the expression of tumor markers, including p53, HER-2, PCNA, EGFR, VEGFR CD-31 and Bcl-2 in patients with oral squamous carcinoma (OSC). This study aimed to determine the expression of proliferating cell nuclear antigen (PCNA), endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31) and human epidermal growth factor receptor-2 (HER-2) according to OSC stage. The prospective study included 62 patients diagnosed with OSC stages II and III. Surgical specimens were obtained from tumor and peritumoral tissues. We determined the pathohistological degree of tumor differentiation and the immunohistochemical expression of PCNA, CD-31 and HER-2 for each specimen. Immunohistochemical analysis of the expression of PCNA in tumor cells demonstrated poor staining of immunoreactive tumor cells in 23 patients (10 in stage II, 7 in stage IIIa and 6 in stage IIIb). Moderately expressed PCNA-immunoreactivity in the tumor cells in 17 patients (7 in stage II, 6 in stage IIIa and 4 in stage III), and extremely strong PCNA-immunoreactive staining in tumor cells of 10 patients with IIIb stage, was observed. These results suggest that PCNA expression combined with pathohistological findings could possess a prognostic value in determining the survival rates for patients with oral squamous cell carcinoma.

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Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma

Cited by 5 publications

References 16 publications

Invasive Lower Lip Squamous Cell Carcinoma Mimicking Traumatic Fibroma: Case Report

Invasive Lower Lip Squamous Cell Carcinoma Mimicking Traumatic Fibroma: Case Report

Unusual Growth of Upper Lip Squamous Cell Carcinoma: A Case Report

Expression of PCNA, CD-31 and HER-2 in Serbian patients with oral squamous cell carcinoma

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