“…Furthermore, metacarpal cortical bone density, which is assessed by digital X-ray radiogrammetry, is significantly associated with a DRF in elderly women [28,29]. The occurrence of DRF is significantly related to hip BMD but not lumbar spine BMD [5,27], and severity of a DRF and cortical thickness of the distal radius are not related to BMD of the lumbar spine, which is mainly trabecular [27,30]. Second, even if trabecular microstructure affects frailty of the distal radius, it may not be accurately evaluated by the lumbar spine TBS due to anatomic site differences.…”