Correlation Between Endogenous Serum Cortisol and Central Serous Retinopathy: A Clinical Study

Abstract

AIMS AND OBJECTIVES To measure the serum cortisol level in patients with acute CSR and thereby assess causal relation of steroid in CSR.  To compare the serum cortisol levels with different clinical parameters of CSR and to prove or refute their association.

Serum cortisol and serum testosterone levels in idiopathic central serous chorioretinopathy

“…Yannuzzi [13] has given a detailed description of the association of ICSC with male sex, middle age and stress, the features of which are competitive drive, a sense of urgency, an aggressive nature, a hostile temperament, intense and sustained drive to achieve, state of restlessness, perception of all responsibilities with an element of challenge, extraordinary mental and physical alertness, desire for recognition and advancement, frequent involvement with deadlines and multiple simultaneous tasks. Ruma Das et al [14] , Shaik M Zakir et al [9] in their study reported similar male dominancy. Various studies show a higher prevalence in men ranging from 72% to 88% with a peak around 45 years in men and higher in women though no age is immune [9] .…”

“…They also reported a significant difference. Similarly Ruma Das et al [14] found that when the cases and controls were compared for mean serum cortisol levels (diurnal samples), statistical significance was obtained with higher values in cases both for the morning ~ 116 ~ (p=0.001) and evening levels. Mean serum cortisol levels compared between ink-blot pattern and smoke-stack patterns on FFA had no statistical significance in either sample.…”

“…Maximum controls (66.67%) had a BCVA of 6/18-6/36, followed by 4 patients with 6/6-6/12 (26.67%) and 1 case had a BCVA of less than 6/60 (6.67%). Ruma Das et al [14] in their study reported that 24 cases (48%) had a best corrected visual acuity of 6/18-6/36; 22 cases (44%) had a BCVA of 6/6 -6/12, while 4 cases (8%) had BCVA of ≤6/60. Maximum controls (30) had a BCVA of 6/18 -6/36 (58%), followed by 11 patients with 6/6 -6/12 (22%); 10 cases had a BCVA of less than 6/60 (20%).…”