Correlation between eosinophil count and soil-transmitted helminth infection in children

Jiero, Syilvia; Ali, Muhammad; Pasaribu, Syahril; Pasaribu, Ayodhia Pitaloka

doi:10.1016/s2222-1808(15)60936-7

Cited by 20 publications

(33 citation statements)

References 18 publications

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“…STH infections have been largely associated with eosinophilia, especially in early stages of infection, when larval migration occurs. The association between eosinophilia and STH in the present study is consistent with results from previous work conducted in Honduras [39, 40] and other countries such as Brazil [41, 42], Philippines [43], Indonesia [44], and Spain [26]. …”

Section: Discussionsupporting

confidence: 93%

“…As a predictor of current helminthic infections, some authors consider eosinophilia's predictive value very limited [38], while others regard it as a suitable indicator of helminthiases in people from tropical and subtropical areas [26, 42, 44, 46]. Our data support the latter since eosinophilia correlated with both STH infection and intensity.…”

Section: Discussionsupporting

confidence: 79%

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Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths

Gabrie

Rueda

Rodríguez

et al. 2016

Journal of Parasitology Research

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Soil-transmitted helminth infections typically induce a type-2 immune response (Th2), but no immunoepidemiological studies have been undertaken in Honduras, an endemic country where the main control strategy is children's annual deworming. We aimed to characterize the immune profile of Honduran schoolchildren harbouring these parasitoses. Demographic and epidemiological data were obtained through a survey; nutritional status was assessed through anthropometry; intestinal parasites were diagnosed by formol-ether and Kato-Katz; and blood samples were collected to determine immunological markers including Th1/Th2 cytokines, IgE, and eosinophil levels. A total of 225 children participated in the study, all of whom had received deworming during the national campaign five months prior to the study. Trichuriasis and ascariasis prevalence were 22.2% and 20.4%, respectively. Stunting was associated with both age and trichuriasis, whereas ascariasis was associated with sex and household conditions. Helminth infections were strongly associated with eosinophilia and hyper-IgE as well as with a Th2-polarized response (increased levels of IL-13, IL-10, and IL4/IFN-γ ratios and decreased levels of IFN-γ). Pathogenic protozoa infections were associated with a Th1 response characterized by elevated levels of IFN-γ and decreased IL10/IFN-γ ratios. Even at low prevalence levels, STH infections affect children's nutrition and play a polarizing role in their immune system.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 79%

Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths

Gabrie

Rueda

Rodríguez

et al. 2016

Journal of Parasitology Research

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“…In this study eosinophil was higher in mixed STHs than in single STHs. Different with study that Sylvia et all, 2014, that there was no significant difference of eosinophil count in children with single and mixed STHs [7]. Some limitations for this study that there wss no questioner for the subjects to avoid allergies, asthma, atopic dermatitis, rheumatology, malignancy, immunodeficiency gastrointestinal which could be a factor contributing the increase of eosinophil.…”

Section: Introductionmentioning

confidence: 63%

“…[4]. STH are a group of parasitic nematode worms that cause infection in humans following either the ingestion of eggs or contact with larvae, which developed rapidly in the warm climate and moist soil that are frequently observed in both tropical and subtropical countries, particularly in developing countries [7]. Concomitant infections are common in nature and often involve parasites.…”

Section: Introductionmentioning

confidence: 99%

“…For A. lumbricoides was classified as light infection if 1 to 4999 epg; moderate infection 5000-49999 and heavy infection > 50000 epg. For T. trichiura and hookworm were classified as light infection if 1 to 999 epg; moderate infection 1000 to 9999 and heavy infection > 10000 epg [7]. Eosinophilia is defined as an increase of eosinophilic leukocytes to more than 500 cells per µl in peripheral blood or elevated percentage of eosinophils > 5% [1], [5].…”

Section: Introductionmentioning

confidence: 99%

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Eosinophilia in Children with Single and Mixed Soil Transmitted Helminthiasis

Panggabean

Nasution

Siahaan

et al. 2017

Proceedings of the 1st Public Health International Conference (PHICo 2016)

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Abstract-Worldwide, helminths infections are by far the leading cause of infection associated-eosinophilia and probably of eosinophilia of all causes. Due to behavioral aspects, partial immunity and other factors, prevalence rates and infection intensity are usually highest in children. Consequently, eosinophilia is common in tropical developing countries. Population based study in rural areas has demonstrated eosinophilia in up to 50 % in children and adults. The objective of this study was to determine eosinophilia in children with Soil Transmitted Helminthiasis (STHs) of SD Panti Asuhan AlJamiyatul Washliyah Pulo Brayan Medan. This was an observational study with cross-sectional approach. In this study, 82 children with STH enrolled. They are divided into two groups single and mixed STHs. All children were examined for eosinophilia. The results showed 40 children (48,8%) with single STHs; 42 children (51,2%) with mixed STH. The intensity of STHs were light infection 89%, moderate 7,3% and heavy infection 3,7%. Eosinophilia was found with mean 6,86% with SD 3,93 on single STHs and 10,12% with SD 6,34 on mixed STHs. It suggested that eosinophilia was higher on mixed STHs than single STH infection. Helminthic infection should be considered an important cause of eosinophilia. The absence of eosinophilia cannot exclude these parasites. However, the incidence and extent of infection related eosinophilia do not depend only on the type, intensity and stage of infection; other factors such as individual differences in innate and adaptive immune responses, epidemiological background, age at first exposure, underlying conditions, etc are important as well. There was a significant difference of eosinophil value between single and mixed STHs on children of SD Panti Asuhan Al-Jamiyatul Washliyah Pulo Brayan Medan. Eosinophilia was higher in mixed STHs.

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Correlation of Eosinofil and Basophil count with intensity of soil transmitted helminth infection among farmers in Bali

Apsari

Arwati

Dachlan

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Correlation between eosinophil count and soil-transmitted helminth infection in children

Cited by 20 publications

References 18 publications

Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths

Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths

Eosinophilia in Children with Single and Mixed Soil Transmitted Helminthiasis

Correlation of Eosinofil and Basophil count with intensity of soil transmitted helminth infection among farmers in Bali

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