Correlation between functional and anatomical assessments by multifocal electroretinography and optical coherence tomography in central serous chorioretinopathy

Abstract

To evaluate the correlation between functional and anatomical assessments with multifocal electroretinography (mfERG) and optical coherence tomography (OCT) in patients with acute central serous chorioretinopathy (CSC). Thirty-four eyes of 34 patients with acute CSC underwent mfERG and OCT examinations. First-order mfERG N1 and P1 response amplitudes and latencies were analyzed.OCT parameters measured included central subretinal fluid (SRF) thickness, central retinal thickness, total central foveal thickness, vertical, and horizontal diameters of SRF, and macular volume. Correlation analyses were performed between best-corrected visual acuity (BCVA), mfERG parameters, and OCT measurements. Correlation analysis showed that logMAR BCVA was significantly correlated with mfERG N1 amplitudes of rings 1 and 2 (P = 0.006), N1 latency of ring 4 (P = 0.012), and P1 latency of ring 1 (P = 0.036). No significant correlation was observed between logMAR BCVA and any of the OCT measurements. For the correlation between mfERG parameters and OCT measurements, mfERG N1 and P1 latencies of the paracentral rings were significantly correlated with the central SRF thickness (P < or = 0.024), diameters of the SRF (P < or = 0.018), and macular volume (P < or = 0.030). MfERG responses but not OCT measurements correlated with logMAR BCVA in patients with acute CSC. The amount of SRF nonetheless correlated with the mfERG N1 and P1 latencies of the paracentral rings, suggesting that impairment in the conduction of electrical responses in the paracentral macula is proportional to the severity of serous macular detachment in CSC. MfERG and OCT can complement each other in the functional and anatomical assessments in CSC.

Quantitative and Qualitative Spectral Domain Optical Coherence Tomography Analysis of Subretinal Deposits in Patients with Acute Central Serous Retinopathy

“…However, we found that neither total central retinal thickness nor central neurosensory retinal thickness was correlated with baseline or final BCVA. This is in concordance with findings of Yip et al [30], who found no correlation between BCVA and both central retinal and total central foveal thickness in acute CSR patients [30]. Additionally, Yip et al [30] found no correlation between BCVA and horizontal and vertical diameters of SRF, as did we.…”

Testing the clinical value of multifocal electroretinography and microperimetry and the effects of intravitreal therapy with ranibizumab on macular function in the course of wet age-related macular degeneration: a 1-year prospective study

“…However, no significant correlation was observed between the mfERG and any of the retinal thickness measured with OCT. Comparably, Yip et al reported no significant correlation between the mfERG of various rings and the OCT parameters in eyes with central serous chorioretinopathy 36. These findings demonstrate that functional assessment using mfERG better reflects the level of VA, and not anatomical evaluation by OCT.…”

Ranibizumab in the treatment of choroidal neovascularisation due to age‐related macular degeneration: an optical coherence tomography and multifocal electroretinography study

“…Finally, the visual acuity and the retinal response density of the foveal area (ring 1) seemed to have little relationship with the foveal thickness. Yip and colleagues reported no significant correlation between the mfERGs of various rings and the OCT parameters in eyes with central serous chorioretinopathy 15 . Also, no significant correlation was observed between the logMAR visual acuity and any of the OCT measurements.…”

“…This may be explained by the fact that macular oedema is only one parameter that can affect visual acuity and the electrical activity of the macula. There are other possible factors that can affect macular function, including the chronicity of the disease, composition of sub‐retinal fluid and pre‐existing photoreceptor damage 15,17 …”