Correlation between glycemic control markers and lipid profile in type 2 diabetes mellitus and impaired glucose tolerance

Biradar, Satish Basanagouda; Desai, Anasuya Sangaraj; Kashinakunti, Sangappa Virupaxappa; Manjula, R; Kallaganad, Gurupadappa; Devaranavadagi, Basavaraj

doi:10.18203/2349-3933.ijam20182489

Cited by 6 publications

(6 citation statements)

References 21 publications

(29 reference statements)

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“…In our study we observed significantly high FBS and HbA1c in hyperglycemic patients (pre-diabetic and diabetic) compared to controls. Our result was consistent with that of Shrestha S et al [11] and Birader SB et al [12].…”

Section: Discussionsupporting

confidence: 94%

“…High HbA1c level indicates poor glycemic control that significantly increases the risk of atherovascular diseases [5]. HbA1c implicates the glycemic status of over previous [8][9][10][11][12] weeks and thus serves as a useful indicator of diabetes progression and onset of its complications [6]. Not only in diabetic patients, HbA1c also acts as marker of CVD in healthy individuals too [7].…”

Section: Introductionmentioning

confidence: 99%

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Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

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Background: Subclinical inflammation characterized by elevated inflammatory markers is found in diabetic patients. Inflammation, an important cardiovascular risk factor, is elevated in diabetics with poor glycemic control than those with good control. Aim: To study the effect of glycemic status on inflammatory markers in pre-diabetes and diabetes. Methods: This study included 300 subjects divided into 3 groups; Control: 100, Pre-diabetes: 100 patients and Diabetes: 100 patients. Basic details of all the participants like age and gender were recorded and laboratory investigations like fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), IL-6, CRP, fibrinogen, uric acid and adiponectin were conducted. Results: Compared to controls, the levels FBS, HbA1c, IL-6, CRP, fibrinogen and uric acid were elevated and adiponectin was decreased in pre-diabetes and diabetes. The inflammatory parameters (IL-6, CRP, fibrinogen, uric acid and adiponectin) were significantly correlated with glycemic parameters (FBS, HbA1c) in diabetes, i.e. r=0.28, r=0.55, r=0.2, r=0.48 and r=-0.4 respectively in case of FBS and r=-0.39, r=0.48, r=0.21, r=0.33 and r=-0.53 respectively for HbA1c. Similarly, in pre-diabetes, FBS correlated significantly with adiponectin (r=-0.19), fibrinogen (r=0.29) and uric acid (r=0.18) while that with HbA1c was significant with adiponectin (r=-0.31), IL-6 (r=0.25), CRP (r=0.21) and fibrinogen (r=0.3). Conclusion:The strong correlations observed between glycemic control parameters and inflammation parameters in prediabetes and diabetes suggested the crucial involvement of inflammation in the diabetes development. So better control of glycemia can cause significant reduction in inflammation and arrest the health burden.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

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“…Dyslipidemia makes diabetics prone to heart disease (CHD and other atherosclerosis complications). Our result concurrent with Sultania S et al (18) , Bhambhani GD et al (19) & Biradar SB et al (20) .…”

Section: Methodssupporting

confidence: 91%

“…Biradar SB et al 2018 (20) the study T2DM patients showed significant increases in TGL and VLDL serum, further the study showed increases in TC and LDL levels that were not statistically significant compared to normal healthy control group. T2DM patients experienced a significant decrease in HDL compared to the normal control group.…”

Section: Result: Graph 1: Showing Age Group Wise Distribution Of T2dmmentioning

confidence: 89%

Study of Hba1c, Lipid Profile and Cyclophilin-a in Diabetes Mellitus

Jha¹,

Badade²,

Rai³

et al. 2019

IJMBS

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Introduction: Diabetes is a chronic disease that occurs when not enough insulin is produced by the pancreas or the body does not use the insulin produced. Because of increased blood glucose levels in the body, serious heart, kidneys, blood vessels, nerves and eyes damage are caused. Report says about 400 million people suffer from diabetes. Therefore present study is aimed to assess levels of HbA1c, Lipid profile and Cyclophilin A in diabetic patient. Material and Methods: The present study includes total 126 subjects comprising of 66 type 2 Diabetes Mellitus patients and 60 healthy individual. Blood samples are collected from the all subjects were processed for HbA1c, Lipid Profile and Cyclophilin A estimation, from OPD and General Medicine Wards. HbA1c is estimated by HPLC, lipid Profile by AU480 and the Cyclophilin A by ELISA method using commercially available Qayee-bio ELISA kit. Conclusion: Present study showed significantly increased levels of HbA1c, Lipid Profile and Cyclophilin A in T2DM patients. The elevated lipid profile may be due to the complication of Diabetic mellitus. CyA is increased as an inflammation marker. Keywords: T2DM: Type 2 diabetes mellitus, HbA1c: Glycosylated Hemoglobin, CyA: Cyclophilin-A

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“…Increase in the serum levels of the hepatic enzymes may lead to reduced concentrations of total protein (TP) and albumin in the serum [7]. Poor glycaemic control during diabetes mellitus causes hyperlipidaemia, which is associated with an increased flux of free fatty acid due to insulin resistance [8,9].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant status and hepato-protective role of Anchomanes difformis in streptozotocin-induced diabetes in male Wistar rats

2020

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SummaryIntroduction: The liver is involved in the metabolism of xenobiotics and their metabolites and it is vulnerable to oxidative damage. Hyperglycaemia is highly implicated in the progression of diabetes mellitus, and adversely affects the liver. Though, conventional hypoglycaemic drugs may be effective in reducing blood glucose, they do not appear to be effective in attenuating the progression of diabetes and its complications.Objective: This study evaluated the ameliorative effects of Anchomanes difformis on hyperglycaemia and hepatic injuries in type 2 diabetes.Methods: Type 2 diabetes was induced in male Wistar rats with a single intraperitoneal injection of streptozotocin (40 mg/kg BW) after two weeks of fructose (10%) administration. Aqueous extract of A. difformis (200 and 400 mg/kg BW) and glibenclamide (5 mg/kg BW) were administered orally for six weeks. Blood glucose concentrations were measured. Serum levels of liver dysfunction markers (ALT, AST, and ALP), total cholesterol, triglycerides, HDL- and LDL-cholesterol were investigated. Total protein, albumin, and globulin were also assessed. Antioxidant parameters: ORAC, GSH, GSSG, SOD, CAT and FRAP were evaluated in the liver while ORAC, FRAP and lipid peroxidation were determined in the serum. Histological examination of the liver tissue was carried out.Results: Treatment with aqueous extract of A. difformis significantly (p<0.05) reduced blood glucose and reversed steatosis in the diabetic-treated rats. The antioxidant status of diabetic-treated rats was significantly (p<0.05) improved. Serum levels of liver dysfunction markers were significantly (p<0.05) reduced in diabetic-treated rats.Conclusion: The findings in this study revealed that 400 mg/kgBW Anchomanes difformis was more effective than 200 mg/kg BW in ameliorating diabetes-induced hepatopathy, however, both doses of Anchomanes difformis demonstrated more antidiabetic ability than glibenclamide. Anchomanes difformis may be a novel and potential therapeutic agent in the management of diabetes and resulted hepatic injuries.

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Correlation between glycemic control markers and lipid profile in type 2 diabetes mellitus and impaired glucose tolerance

Cited by 6 publications

References 21 publications

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Study of Hba1c, Lipid Profile and Cyclophilin-a in Diabetes Mellitus

Antioxidant status and hepato-protective role of Anchomanes difformis in streptozotocin-induced diabetes in male Wistar rats

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