Correlation between human papillomavirus infection and bladder transitional cell carcinoma

Barghi,; Haji-Mohammadmehdi-Arbab, Amir; Moghaddam, Smm Hosseini; Kazemi, Bahram

doi:10.1186/1471-2334-5-102

Cited by 43 publications

(52 citation statements)

References 14 publications

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“…In bladder cancer group, we have found that HPV 18 was the most frequent type, both in tissue and in urine samples (22.2%). These results are in line with other previous reports (20). Moreover, we found HPV 45 both in tissue (18.6%) and in urine samples (13.9%).…”

Section: Discussionsupporting

confidence: 83%

Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study

Dan

2011

Oncol Rep

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Abstract.The relationship between urothelial bladder cancer and high-risk human papillomaviruses (HR-HPV) is still a poorly understood entity, even if some studies have supposed a probably correlation. The aim of the present study was to assess the potential relationship between the presence of HR-HPV and non-muscle invasive urothelial bladder cancers (NMIBC). One hundred and thirty-seven subjects (78 patients affected by NMIBC and 59 controls) were recruited in this prospective study. HR-HPV DNA was evaluated both in urine and tumour tissues. Data from patients were compared with data from controls. The relationship between patients and controls, in terms of HR-HPV presence was performed. The relationship between all pathological data and HR-HPV presence in patient group was carried out. HR-HPV DNA in tissue was found in 27 of 78 (34.6%) tumour samples and in 6 of 59 (10.1%) specimens from TUR-P, with a statistically significant difference (p=0.0009; dF=1; 2 =10.98). HR-HPV DNA in urine was found in 36 of 78 (46.1%) samples obtained from patients, whereas in only 8 of 59 (13.5%) samples from controls (p<0.0001: dF=1; 2 =16.37). A statistical significant difference in terms of HR-HPV frequency between high-grade and low-grade urothelial bladder cancer, was found (p=0.032; RR=0.52 -95% CI 0.27-0.93; OR=0.34 -95% CI 0.13-0.90). In conclusion, this study highlights the correlation between urothelial bladder cancer and high-risk type HPV infection, suggesting the potential etiopathogenetic role of HR-HPV in urothelial bladder cancer development. IntroductionApproximately 67,160 new bladder cancer cases are expected in the United States in 2007 with 13,750 estimated deaths (1).Moreover, the high recurrence rate and the percentage of adjuvant intravesical therapy failure contribute to bladder carcinoma becoming a social problem (2). In addition, following aspects of the urothelial bladder carcinoma natural history are partially unknown: i) whether a genetic factor exists which determines its predisposition (although there are several oncogenes involved), ii) which are the major risk factors involved in its genesis preventing us from putting into practice an effective prevention campaign. Among all etiopathogenetic factors and co-factors that contribute to urothelial bladder cancer development, we focused our attention on the role of human papillomavirus (HPV), which has been considered as a possible aetiologic agent (3). HPV is one of the most common sexually transmitted infections worldwide and it is associated with lesions ranging from benign cutaneous warts to malignancies, like cervical, penile or anal cancers (4). About 13 different HPV genotypes are associated with malignancy and are referred to as high-risk HPV (HR-HPV) (5,6). The oncogenic potential of HR-HPV types lies in the oncoproteins E6 and E7, which bind to and modulate a number of different gene products, in particular, the tumour suppressors p53 and pRb. These interactions lead to a disturbance of cell cycle control and a deficiency in DNA repair, res...

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Section: Discussionsupporting

confidence: 83%

Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study

Dan

2011

Oncol Rep

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“…[10][11][12] However, in a study involving Iranian patients, HPV DNA was detected in slightly over 35% of urothelial neoplasia cases, and 81% of the viral strains identified were HPV type 18, which is considered a high-risk strain for the development of uterine cervical neoplasia. 34 More recently, Li et al 7 have also shown the presence of HPV infection in bladder cancer. They implicated HPV type 16, which is also considered a high-risk strain for the development of uterine cervical neoplasia.…”

Section: Resultsmentioning

confidence: 98%

p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma

Alexander

Kum

et al. 2012

Modern Pathology

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Squamous cell carcinoma of the urinary bladder is unusual and of unknown etiology. There is a wellestablished association between human papillomavirus (HPV) infection and the development of cervical and head/neck squamous cell carcinomas. However, the role of HPV in the pathogenesis of squamous cell carcinoma of the urinary bladder is uncertain. The purposes of this study were to investigate the possible role of HPV in the development of squamous cell carcinoma of the urinary bladder and to determine if p16 expression could serve as a surrogate marker for HPV in this malignancy. In all, 42 cases of squamous cell carcinoma of the urinary bladder and 27 cases of urothelial carcinoma with squamous differentiation were investigated. HPV infection was analyzed by both in situ hybridization at the DNA level and immunohistochemistry at the protein level. p16 protein expression was analyzed by immunohistochemistry. HPV DNA and protein were not detected in 42 cases of squamous cell carcinoma (0%, 0/42) or 27 cases of urothelial carcinoma with squamous differentiation (0%, 0/15). p16 expression was detected in 13 cases (31%, 13/42) of squamous cell carcinoma and 9 cases (33%, 9/27) of urothelial carcinoma with squamous differentiation. There was no correlation between p16 expression and the presence of HPV infection in squamous cell carcinoma of the bladder or urothelial carcinoma with squamous differentiation. Our data suggest that HPV does not play a role in the development of squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation. p16 expression should not be used as a surrogate marker for evidence of HVP infection in either squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation as neither HVP DNA nor protein is detectable in these neoplasms.

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“…Until now, conflicting findings have been reported on association between HPV infection and bladder carcinoma [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. In the present study, we analyzed urothelial bladder tumor samples for HPV in order to clarify the controversial role of HPV in bladder cancers.…”

Section: Introductionmentioning

confidence: 88%

Role of human papillomavirus in the development of urothelial carcinoma

et al. 2010

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It has been estimated that almost 10% of the worldwide cancer burden is linked to human papillomavirus (HPV) infection. Although the association between HPV and bladder carcinoma has been extensively investigated, data on the role of HPV in bladder carcinogenesis are controversial. The aim of the study was to assess the possible role of human papillomavirus in the development of urothelial bladder carcinomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. Seventy urothelial bladder carcinoma tissues were screened by nested-polymerase chain reaction (PCR) for HPV DNA with a control group of total 18 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia III (CIN III). In the study group, we did not find HPV DNA positivity in any of the urothelial carcinomas. In the control group, 15 out of 18 (83.3%) samples were positive for the HPV DNA. These results indicated that there was no association between HPV infection and urothelial carcinomas.

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Correlation between human papillomavirus infection and bladder transitional cell carcinoma

Abstract: Background: To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC).

Cited by 43 publications

References 14 publications

Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study

Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study

p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma

Role of human papillomavirus in the development of urothelial carcinoma

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