Correlation between human papillomavirus infection and histopathological diagnosis of women in Northeast Brazil

Miranda, Paulo Henrique Oliveira de; Chagas, Bárbara Simas; Coêlho, Maria Rosângela Cunha Duarte; Neto, Jacinto da Costa Silva

doi:10.1002/jmv.26101

Cited by 6 publications

(4 citation statements)

References 41 publications

(74 reference statements)

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“…Moreover, the results observed here revealed that, when multiple infections were considered, more than half of the participants (57.8%) were infected with genotypes other than 16 and 18, which are not covered by the vaccine used in Brazil (8). This frequency is remarkably high compared to a similar study performed in Northeast Brazil (Agreste region) in women with abnormal cervical histopathological diagnosis, which found 27% of patients infected with HPV other than 16 and 18 (35). These findings have major implications for local public health policies, especially primary prevention strategies, and corroborate the need to identify the genotypic HPV diversity at the regional level.…”

Section: Discussionsupporting

confidence: 61%

High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil

Fantin

Freitas

Teles

et al. 2023

Braz J Med Biol Res

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Cervical cancer is a serious public health problem in Brazil, especially in Manaus (Amazonas), the city with the highest incidence rate of cervical cancer in the country. Persistent infection with oncogenic human papillomavirus (HPV) genotypes is the cause of disease development. The aim of this study was to investigate the prevalence of oncogenic genotypes in women at high risk for cervical precancer examined in two policlinics in Manaus. One hundred and two patients who underwent colposcopy took part in the research. The DNA samples obtained from the cervical epithelium were analyzed by PCR with type-specific primers for the detection of eight oncogenic genotypes, which were chosen based on previous studies. The presence of HPV virus was detected in all samples. The most prevalent oncogenic genotypes were 18 (47.1%) and 16 (45.1%). Interestingly, HPV 18 was considered uncommon in this region. In addition to these, genotypes 31 (19.6%), 58 (19.6%), 33 (18.6%), and 45 (15.7%) also had a relatively high frequency in this population. Fifty-six women (54.9%) had multiple infections with up to five oncogenic types. Also, the presence of genotypes other than 16 and 18 was observed in most samples (57.8%), which also deserves attention since they are not covered by currently available vaccines against HPV in Brazil. The high prevalence and multiple infections with several oncogenic HPV genotypes in association with precursor lesions for cervical cancer highlighted the need to improve strategies to prevent this disease in Amazonas.

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Section: Discussionsupporting

confidence: 61%

High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil

Fantin

Freitas

Teles

et al. 2023

Braz J Med Biol Res

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“…However, there are reported cases where PCR is negative and histology is positive (Figures 4 and 5 ) [ 70 ]. This may be related to the fact that a limited number of viral strains are considered in the PCR test [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus: Current Knowledge and Focus on Oral Health

Fiorillo

Cervino

Surace³

et al. 2021

BioMed Research International

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The human papilloma virus (HPV) is responsible for different pathological manifestations in humans. This agent gives rise to lesions of different types and in different areas of the organism, including the oral cavity. The aim of this study is to show which are the main diseases for which HPV is responsible and to bring to light some of the interceptive and therapeutic strategies. The analysis was conducted by consulting the major scientific databases with the aim of obtaining information on the characteristics of oral HPV and its management; furthermore, the literature was supported by some clinical cases proposed by the authors. The role of dentistry is essential in the early diagnosis of this type of pathologies and above all in knowing how to direct patients towards a path that can lead to patient management, especially in the event that these lesions have a malignant potential. Enhancing the knowledge and role of dentistry can lead to early diagnosis of this type of injury, intercepting a pathology that could have multiorgan implications.

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“…Human Papillomavirus (HPV) plays an important role in cervical cancer. Epidemiological studies claim that human papillomavirus (HPV) infection is a necessary condition for cervical cancer development (40)(41)(42). However, the mechanism of HPV in cervical cancer need to be further studied.…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel circRNA, hsa_circ_0065898, that regulates tumor growth in cervical squamous cell carcinoma

Ni¹,

Liu²,

Deng³

2021

Transl Cancer Res TCR

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Background: Circular RNAs (circRNAs) were reported to play an important role in regulating tumor pathogenesis. The molecular mechanism of circRNAs in cervical squamous cell carcinoma (CSCC) remains poorly understood. We aimed to identify the circRNAs differentially expressed, and to investigate the role of a novel circRNA, hsa_circ_0065898, in regulating proliferation, migration, and invasion in CSCC.Methods: The online Kaplan-Meier Plotter was used to analyze the relationship between miRNA expression and overall survival. Bioinformatics tools, such as R, Cytoscape, and Perl, were used to analyze the Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, proteinprotein interaction (PPI) network, and regulatory network. The expression level of hsa_circ_0065898 in CSCC cell lines was evaluated using quantitative polymerase chain reaction in vitro. The cell counting kit-8 (CCK-8) and transwell assays were used to assess cell proliferation, migration, and invasion.Results: circRNA expression data (GSE102686) was downloaded from the Gene Expression Omnibus database, and this included data from 5 CSCC patients and 5 normal tissues. 13 differentially expressed circRNAs were identified, which included 9 upregulated circRNAs and 4 downregulated circRNAs. GO enrichment analysis showed that the target genes of miRNAs associated with hsa_circ_0065898 were enriched in ubiquitin-protein transferase activity, ubiquitin-like protein transferase activity, core promoter sequence-specific DNA binding, mRNA 3'-UTR AU-rich region binding, core promoter binding, and so on. KEGG showed that the Hippo and p53 signaling pathways played significant role in the pathway network.Hsa_circ_0065898 was significantly overexpressed in the CSCC cell lines. Hsa_circ_0065898 facilitated cell proliferation, migration, and invasion in CSCC.Conclusions: This study identified differentially expressed circRNAs and constructed the regulatory network of hsa_circ_0065898 targeting microRNAs and mRNAs. We demonstrated that hsa_circ_0065898 promoted CSCC cell proliferation, migration, and invasion. Hence, hsa_circ_0065898 might be useful as a biomarker for CSCC diagnosis and targeted therapy.

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Correlation between human papillomavirus infection and histopathological diagnosis of women in Northeast Brazil

Cited by 6 publications

References 41 publications

High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil

High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil

Human Papilloma Virus: Current Knowledge and Focus on Oral Health

Identification of a novel circRNA, hsa_circ_0065898, that regulates tumor growth in cervical squamous cell carcinoma

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