Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

Abstract

The aim of this study was to evaluate the prevalence of periapical cysts, identify their clinical and microscopic features and correlate their microscopic features with the inflammatory infiltrate present in the lesion site. A total of 214 cases were collected over a 10-year period. Clinical data, including gender, age, race, symptoms and location of the lesion, were recorded. Two independent examiners with no prior knowledge of the patients' clinical data conducted the microscopic evaluations. Statistical analyses were performed using Fisher's or chi-square tests at a 5% level of significance. The results showed that periapical cysts were more prevalent in white women, with a mean age of 35 years, and in the anterosuperior region. The majority of the lesions were lined by atrophic cystic epithelium, which was associated with moderate inflammatory infiltrate in the cystic capsule (p < 0.01), with a diffuse localization pattern (p = 0.03) and absence of neutrophils (p = 0.01). Our findings suggest that periapical cysts lined by atrophic epithelium are related to the presence of moderate mononuclear inflammatory infiltrate.

Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma

“…Moreover, host responses such as inflammation (4), angiogenesis (5), and, consequently, bone resorption (1) could modify the severity and prognoses of ICALs. Differential diagnosis among all ICALs is possible only with histopathological examination (6). Moreover, it was suggested that radiographic diagnosis of ICALs should not be used for scientific investigations (7).…”

Quiste radicular de origen odontogénico

“…Scholl et al [23] reportan que el tratamiento de los quistes verdaderos consiste en: enucleación, resección radicular en caso de molares, marsupialización, tratamiento de conductos retrógrado o exodoncia del diente comprometido [23][24][25][26][27][28][29][30][31][32][33][34][35]. Las lesiones de quistes verdaderos son las que presentan menor probabilidad de resolverse mediante endodoncia convencional, puesto que están aisladas de los irritantes del canal radicular y son autosostenidas [74].…”

“…El 9% corresponde a quistes verdaderos, que disminuyen la probabilidad de eliminarse mediante tratamiento endodóntico convencional [7][8][9][10][11]29]. La mayor prevalencia de quiste radicular inflamatorio se presenta en mujeres y en edad adulta [21,33]. Algunos artículos reportan que no existe preferencia de edad ni sexo [6][7][8][9][10][11][12][13][14][15][16][17][18], mientras que otros autores reportan que esta lesión es más frecuente en el sexo masculino y que afecta la región anterior del maxilar [7-12, 22, 34, 35].…”

Immunohistochemical expression of TGF-β1 and MMP-9 in periapical lesions

“…6,7 Several immune/inflammatory mediators and proteases may be involved in the formation of periapical granulomas and radicular cysts, such as transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9). 8,9 TGF-β1 is a polypeptide member of the transforming growth factor-β superfamily of cytokines, which is secreted by platelets and inflammatory cells. It performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis and inflammation, as well as tissue repair.…”