Correlation between intimal thickness and fluid shear in human arteries

Friedman, Morton H.; Hutchins, Grover M.; Bargeron, C. B.; Deters, O. J.; Mark, F.

doi:10.1016/0021-9150(81)90027-7

Cited by 314 publications

(165 citation statements)

References 10 publications

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“…In both the coronary artery and the aorta, a negative association between shear stress and intimal thickness was indicated. [23][24] Unlike the TA, the AA contains the renal, mesenteric and iliac artery bifurcations. The coronary arteries are of smaller caliber than the aorta.…”

Section: Discussionmentioning

confidence: 99%

Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Homma

Troxclair

Zieske³

et al. 2008

Atherosclerosis

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Section: Discussionmentioning

confidence: 99%

Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Homma

Troxclair

Zieske³

et al. 2008

Atherosclerosis

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“…After 2 weeks, the smooth muscle cell content of the arterial wall does not appear to change, but matrix production continues, resulting in intimal thickening. 29 Hemodynamic forces have been shown to modulate intimal hyperplasia (IH) at regions prone to atherogenesis 30 and to restenosis after percutaneous transluminal coronary angioplasty 31 by regulation of VSMC proliferation 32 and migration. 6 Kohler and Jawien 6 showed that early IH is increased when flow is reduced after balloon injury of the rat carotid artery.…”

Section: Discussionmentioning

confidence: 99%

Increased Flow and Shear Stress Enhance In Vivo Transforming Growth Factor-β1 After Experimental Arterial Injury

Song

Kocharyan

Fortunato

et al. 2000

ATVB

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Abstract-We have previously demonstrated that high-flow (HF) conditions inhibit experimental intimal hyperplasia.We hypothesized that such flow conditions may alter transforming growth factor-␤1 (TGF-␤1) after mural injury. The right common carotid artery (CCA) was balloon-injured in 54 New Zealand White male rabbits. Flow was thereafter preserved (normal flow [NF]), reduced by partial outflow occlusion (low flow [LF]), or increased by ligation of the left CCA (HF). Four sham-operated animals served as uninjured controls. Mean blood flow and pressure in the right CCA were measured before and after flow modulation and before euthanasia (3, 7, and 14 days). TGF-␤1 mRNA and protein levels in the right CCA were determined by Northern and ELISA analyses at each time point. At 7 and 14 days, intimal hyperplasia was quantified, and the transmural localization of TGF-␤1 was determined by immunohistochemical analysis. Mean flow was reduced from 22Ϯ1 to 10Ϯ3 mL/min in the LF group and increased to 34Ϯ2 mL/min in the HF group (PϽ0.001). Blood pressure was not different among the flow groups for all time points. Wall shear stress was markedly decreased in the LF group to 14Ϯ4 dyne/cm 2 and increased in the HF group to 63Ϯ6 dyne/cm 2 at 7 days compared with values in uninjured controls (39Ϯ2 dyne/cm 2 , PϽ0.001) and the NF group (44Ϯ7 dyne/cm 2 , PϽ0.001). At 14 days, wall shear stress was similar among the flow groups. The intima-to-media ratio was 5-and 2-fold greater in the LF group than in the HF and NF groups at 14 days. mRNA levels for TGF-␤1 and its active ligand were increased in the HF group by at least 2-and 3-fold, respectively, at 3 and 7 days compared with levels in uninjured controls and the LF group (PϽ0.05) but were not different among the flow groups at 14 days. TGF-␤1 preferentially localized in the abluminal vascular smooth muscle cells of the HF arterial segments. Flow-and shear-mediated release of TGF-␤1 may therefore play a role in abrogating the proliferative and migratory response of vascular smooth muscle cells in the early stages after mural injury.

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“…Therefore, a thorough understanding of blood dynamics in human vessels is of great interest, as it is well known that the flow pattern interacts directly with the vessel walls and, thus, can cause both beneficial and detrimental effect on its endothelium (type of cells that cover blood vessels) walls (Friedman et al [2] and Ku et al [3]). A deep knowledge of blood-flow patterns is essential to identify relationships between the patterns and the diseases that form on arteries and vein branches, therefore, the study of physiological blood flow is quite important and nowadays the computational simulation is playing a significant role in this field.…”

Section: Introductionmentioning

confidence: 99%

Investigation of spiral blood flow in a model of arterial stenosis

Paul

Larman

2009

Medical Engineering & Physics

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Abstract:The spiral component of blood flow has both beneficial and detrimental effects in human circulatory system (Stonebridge and Brophy [1]). We investigate the effects of the spiral blood flow in a model of three-dimensional arterial stenosis with a 75% cross-sectional area reduction at the centre by means of computational fluid dynamics (CFD) techniques. The standard k-ω model is employed for simulation of the blood flow for the Reynolds number of 500 and 1000. We find that for Re=500 the spiral component of the blood flow increases both the total pressure and velocity of the blood, and some significant differences are found between the wall shear stresses of the spiral and non-spiral induced flow downstream of the stenosis. The turbulent kinetic energy is reduced by the spiral flow as it induces the rotational stabilities in the forward flow. For Re=1000 the tangential component of the blood velocity is most influenced by the spiral speed, but the effect of the spiral flow on the centreline turbulent kinetic energy and shear stress is mild. The results of the effects of the spiral flow are discussed in the paper along with the relevant pathological issues.

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Correlation between intimal thickness and fluid shear in human arteries

Cited by 314 publications

References 10 publications

Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Increased Flow and Shear Stress Enhance In Vivo Transforming Growth Factor-β1 After Experimental Arterial Injury

Investigation of spiral blood flow in a model of arterial stenosis

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