Correlation between knowledge and attitudes of female high school students regarding cervical cancer in Denpasar, Bali

Abstract

Background: MRCC is a devastating disease with poor long-term outcomes. The addition of bevacizumab (BEV) to chemotherapy (CT) significantly improved overall survival (OS) in MRCC patients (pts). Aim: to characterize clinico-pathologic features associated with CR and its impact on outcome of MRCC pts. Methods: Single-institution prospective series of MRCC pts who were treated with 1 st line CT between 2005 and 2018. CR was defined by Response Evaluation Criteria in Solid Tumors (RECIST v1). Prognostic and predictive value of "Moore criteria" was evaluated.Results: 98 pts (61% squamous; 29% adenocarcinoma; 8% others) with median age of 49 years (28-77) were investigated. 57 pts (58%) had prior CT-radiation; 73 pts (75%) had recurrent/persistent disease (39 pts > 12 months (m) disease free interval) and 23 pts (24%) were stage IVb at diagnosis (47% visceral involvement). Moore risk distribution: 9 high, 53 medium, 9 low risk. 70 pts (72%) platinum-based-CT (PCT) (46% Cisplatin; 26% Carboplatin); 24 pts (25%) received CT þ BEV. After a median followup of 21.2 m, overall response rate (RR) was 59%, median PFS was 7 m (CI95% 6-9) and median OS 14 m (CI95% 11-24). Moore criteria correlated with prognosis (highrisk pts had significantly worse OS, HR ¼ 25, p < 0.001). Higher RR was observed among low and intermediate risk pts (77% and 54%) as compared to high (11%, p < 0.001). CRs occurred in 21/94 (22%) evaluable pts (BEV group 5/23; non-BEV 16/ 71, p ¼ 1). Factors associated with CR in univariate analysis: no visceral involvement (OR ¼ 1.54, p < 0.01), no prior CT (OR ¼ 1.85, p ¼ 0.04) and Moore criteria low/intermediate (vs. high, OR ¼ 2.36, p ¼ <0.01). Median time to CR and median duration of CR were 4.6 m (4.1 -5.3) and 7.4 m (3.6-NR), respectively. CR significantly impacted on PFS (14.6 m vs 6.5 m non-CR, p < 0.001) and OS (NR vs 11 m non-CR, p < 0.001). Nine pts discontinued treatment due to toxicity (1 pt had vesico-vaginal fistula related to BEV). Conclusions: CR is a meaningful surrogate marker for improved PFS and OS in MRCC pts treated with 1 st line CT. In our series, visceral involvement, prior CT and Moore criteria were identified as predictive markers for CR. Legal entity responsible for the study: A. Oaknin.

Prevalence and Correlates of Cervical Cancer Prevention Knowledge Among High School Students in Ghana

“…Phase 1: Item Generation and Content Validity. A pool of 23 candidate items drawn from the previous literature and survey instruments assessing cervical cancer and HPV knowledge among adolescents, both in and out of school, were considered for selection (Ayissi et al, 2012;Bardaji et al, 2018;Bowyer et al, 2013;Martianus et al, 2018;Poudel & Sumi, 2019). In line with the recommendations of Lynn (1986), 12 experts including health behavior scientists (n=4), epidemiologists (n=2), nurses (n=2), doctors (n=2), and psychologists (n=2) were purposively selected from the research team's research and clinical networks.…”

“…There are a disproportionately small number of studies about cervical cancer knowledge among high school girls. Of ten studies identified in the literature ( Ayissi et al, 2012 ; Bardaji et al, 2018 ; Bowyer et al, 2013 ; Ifediora & Azuike, 2018 ; Lee et al, 2014 ; Mapanga et al, 2019 ; Martianus et al, 2018 ; Opoku Agyemang & Manortey, 2018 ; Poudel & Sumi, 2019 ; Rashwan et al, 2013 ), only three were conducted in Western Africa. In Cameroon, more than 70% of girls have been reported to have knowledge about cervical cancer risk factors and HPV vaccination ( Ayissi et al, 2012 ; Bardaji et al, 2018 ).…”