Correlation between loose density and compactibility of granules prepared by various granulation methods

Murakami, Hideki; Yoneyama, Takashi; Nakajima, Kingo; Kobayashi, Masao

doi:10.1016/s0378-5173(01)00575-0

Cited by 38 publications

(22 citation statements)

References 14 publications

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“…In the literature, the size distribution results have varied. Hausman (7) showed a wider distribution for fluidized bed compared with high-shear granulations while others (4,10,11) have reported the reverse with large agglomerates from the high-shear granulation contributing to its wide size distribution. Different procedures were used for the granulations including liquid binder spray rate and processing time.…”

Section: Discussionmentioning

confidence: 98%

A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods

Morin

Briens

2014

AAPS PharmSciTech

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Abstract. Placebo granules were manufactured by both wet high-shear and fluidized-bed techniques. The granules were compared based on size, shape, surface morphology, and a variety of different flowability measurements. This comparison showed that granule formation and growth were different, with induction growth for high-shear granulation and steady growth for fluidized-bed granulation. Final granules from high-shear granulation were more spherical and dense compared with the irregular granules from fluidized-bed granulation. The high-shear granules demonstrated better overall flow properties.

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Section: Discussionmentioning

confidence: 98%

A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods

Morin

Briens

2014

AAPS PharmSciTech

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“…Aqueous solutions of PEG 6000 in high concentration were used successfully as the granulation liquid in a study of the effect of granulation methods on the loose density and compactability of granules. 12 Based on these findings and the literature published on melt agglomeration in rotary processors, it might be possible to prepare agglomerates with high contents of PEG without the use of elevated temperatures in a rotary processor. When suitable process conditions are used, the dissolved PEG binder will solidify in the rotary processor shortly after atomization because of the evaporation of water.…”

Section: Introductionmentioning

confidence: 87%

Investigation of a 2-step agglomeration process performed in a rotary processor using polyethylene glycol solutions as the primary binder liquid

Kristensen

2006

AAPS PharmSciTech

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The purpose of this research was to investigate the use of polyethylene glycol (PEG) solutions as the primary binder liquid in a 2-step agglomeration process performed in a rotary processor and characterize the resulting granules and their tableting characteristics. This was done by granulation of binary mixtures of microcrystalline cellulose (MCC) and either lactose, calcium phosphate, acetaminophen, or theophylline, in a 1:3 ratio, using a 50% (wt/wt) aqueous solution of PEG and water as the binder liquid. Formulations containing lactose were agglomerated using 5 different amounts of the PEG binder solution, giving rise to a PEG content in the range of 6% to 43% (wt/wt). The process outcome was characterized according to adhesion, yield, and water requirement, and the prepared granules were characterized according to size, size distribution, and flow properties as well as tableting properties. The agglomeration of all mixtures resulted in high yields of freeflowing agglomerates and gave rise to good reproducibility of the investigated agglomerate characteristics. The process allowed for the incorporation of 42.5% (wt/wt) PEG, which is higher than the percentage of PEG reported for other equipment. Tablets of sufficient strength could be prepared with all investigated excipients using 20% wt/wt PEG; higher PEG contents gave rise to adhesion and prolonged disintegration. In conclusion, agglomeration in a torque-controlled rotary processor using solutions of PEG as the primary binder liquid was found to be a robust process, suitable for the incorporation of high contents of PEG and/or drug compounds.

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“…If we could prepare microspheres made of CO3Ap, they are expected to be a good candidate for a bone substitute with excellent resorbability. Several researchers 14,15) have reported on 16) , tumbling granulation 17) , agitation fl uidized-bed granulation 18) and other methods 19) . Among them, tumbling granulation is a suitable for our purpose since large size ceramic microsphere can be prepared with high productivity and without valuable equipment.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor

et al. 2012

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Spherical carbonate apatite (CO3Ap) microspheres approximately 1 mm in diameter were fabricated by granulation of calcium hydroxide around a core followed by carbonation and phosphatization through dissolution-precipitation reaction. CO3Ap microspheres with high uniformity could not be achieved without using a core. Solid CO3Ap microspheres were obtained using a calcite core whereas hollow CO3Ap microspheres were obtained using a NaCl core. The obtained microsphere was identifi ed as B-type CO3Ap by Fourier transform infrared analysis and the carbonate content was approximately 7-8 wt% regardless of the type of core used for sample preparation. The mechanical strength of both the solid and hollow CO3Ap microspheres was suffi cient for practical use as a bone substitute.

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Correlation between loose density and compactibility of granules prepared by various granulation methods

Cited by 38 publications

References 14 publications

A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods

A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods

Investigation of a 2-step agglomeration process performed in a rotary processor using polyethylene glycol solutions as the primary binder liquid

Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor

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