A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods

Morin, Garett; Briens, Lauren

doi:10.1208/s12249-014-0134-7

Cited by 41 publications

(13 citation statements)

References 7 publications

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“…Circularity generally depends on the method of granulation. 21) Our results were similar to those obtained with granules produced by rotary granulation, which indicated that the mechanism of granulation in our study was rotation of granules in the vessel.…”

Section: Available Water Content Range For 20% Ibp Granulessupporting

confidence: 90%

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Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer

Eda

Miyazaki

Uchino

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

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A concise spherical granulation method is required to prepare extemporaneously granules remanufactured from oral dosage forms for administration to individuals who cannot swallow tablets or capsules. In this study, we determined the feasibility of spherical granulation using a planetary centrifugal mixer. A model formulation, 20% ibuprofen (IBP) granules, was prepared using a lactose/cornstarch (7 : 3, w/w) mixture or D-mannitol as diluents, and changes in granule characteristics (mean diameter (d50), distribution range of granule size (span), and yield) were evaluated according to the amount of water added and the granulation time. The amount of water was assessed using the plastic limit value as measured using a digital force gauge. We successfully produced granules, and larger amounts of water and longer granulation times resulted in larger d50 values and smaller span values. The optimal granulation time was 45 s and the optimal water contents were 70 and 67.5% of the plastic limit value for the lactose/cornstarch mixture and D-mannitol, respectively. When compared to commercial 20% IBP granules, powder X-ray diffraction and differential scanning calorimetry analyses showed that the granulation process did not alter the crystallinity of the drug. Thus, this novel granulation method using a planetary centrifugal mixer may be a promising technique for compounding in pharmacies and in pharmaceutical manufacturing.

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Section: Available Water Content Range For 20% Ibp Granulessupporting

confidence: 90%

“…In previous studies that determined PL values, a wet mass was produced using a mortar and pestle, and then rolled into a rod by hand. 20) In the present method, a wet mass was produced in a closed vessel using a mixer, and force measurements were acquired within in a few seconds using a digital gauge.…”

Section: Resultsmentioning

confidence: 99%

Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer

Eda

Miyazaki

Uchino

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…-3 -more irregular shape than those produced by using rotating drums and mechanical shear mixer (Jacob, 2007;Ji, Fitzpatrick, Cronin, Fenelon, & Miao, 2017;Morin & Briens, 2014).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Impact of fluidized bed granulation on structure and functional properties of the agglomerates based on the durum wheat semolina

Bellocq

Cuq

Ruiz

et al. 2018

Innovative Food Science & Emerging Technologies

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The granulation step determines the production yield and the final characteristics of the agglomerated couscous grains of durum wheat. The objective of the present work was to explore the capability of the fluidised bed technology to produce agglomerates of durum wheat semolina. The impacts of different processing conditions have been investigated on the structure and functional properties of the agglomerates. The size, shape, water content, compactness, and mechanical strength of the granules were measured. The fluidized bed agglomeration process has been found to produce agglomerates of durum wheat with different attributes compared to those produced by granulation using the low shear mixers. The results were discussed in regard to the hydro-textural approach, in order to get a better understanding of the mechanisms and relationships between process, structure, and properties. Two major agglomeration mechanisms contribute to the growth of the wet agglomerates: a fractal-structuring process followed by a phenomenon of densification. By studying the evolution of the compactness, diameter and water content, it was demonstrated that inter granular arrangements led to an expansion followed by a densification of the wet agglomerates. A relationship was proposed to describe the growth using a fluidized bed of the wet agglomerates of durum wheat semolina

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“…In fluid bed granulators, the powder bed is first fluidized by a flow of air injected upward through a distributor plate at the base of the granulator, and then the liquid binder is sprayed through a nozzle onto the fluidized bed to agglomerate powder in granules. When binder spraying is stopped, the granules continue to dry in the fluidizing airstream, avoiding the use of a following drying step [18]. This type of granulator is flexible, relatively easy to scale, difficult for cohesive powders, and good for coating applications [16].…”

Section: Wet Granulation Process: Apparatus and Process Parameters 2mentioning

confidence: 99%

Inside the Phenomenological Aspects of Wet Granulation: Role of Process Parameters

Simone¹,

Caccavo²,

Dalmoro³

et al. 2018

Granularity in Materials Science

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Granulation is a size-enlargement process by which small particles are bonded, by means of various techniques, in coherent and stable masses (granules), in which the original particles are still identifiable. In wet granulation processes, the powder particles are aggregated through the use of a liquid phase called binder. The main purposes of sizeenlargement process of a powder or mixture of powders are to improve technological properties and/or to realize suitable forms of commercial products. A modern and rational approach in the production of granular structures with tailored features (in terms of size and size distribution, flowability, mechanical and release properties, etc.) requires a deep understanding of phenomena involved during granules formation. By this knowledge, suitable predictive tools can be developed with the aim to choose right process conditions to be used in developing new formulations by avoiding or reducing costs for new tests. In this chapter, after introductive notes on granulation process, the phenomenological aspects involved in the formation of the granules with respect to the main process parameters are presented by experimental demonstration. Possible mathematical approaches in the granulation process description are also presented and the one involving the population mass balances equations is detailed.

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A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods

Cited by 41 publications

References 7 publications

Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer

Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer

Impact of fluidized bed granulation on structure and functional properties of the agglomerates based on the durum wheat semolina

Inside the Phenomenological Aspects of Wet Granulation: Role of Process Parameters

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