Correlation Between Macular Thickness and Glaucomatous Visual Fields

Boling, Whitney; WuDunn, Darrell; Cantor, Louis B.; Hoop, Joni; James, Morgan H.; Nukala, Vamsi

doi:10.1097/ijg.0b013e318239c32b

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…This is based on the assumption that the center of optic nerve is 5 mm from the fovea and the physiological blind spot is 15 degrees from fixation. 16 VF defects within the central 8 points were classified as follows: no central defect, superior VF defect, inferior VF defect, and a defect involving both hemifields. The "no central defect" was defined as no point with P < 0.01 or smaller within the central 8 points on the pattern deviation probability map.…”

Section: Pattern Of Central Vf Defectsmentioning

confidence: 99%

Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects

Jeong

Kang

Kim

et al. 2015

Journal of Glaucoma

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Section: Pattern Of Central Vf Defectsmentioning

confidence: 99%

Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects

Jeong

Kang

Kim

et al. 2015

Journal of Glaucoma

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“…Asymmetry has been shown to be a sensitive indicator for early glaucoma [ 70 ]. Because the central portion of the visual field is affected from the macular ganglion cell loss, structural and function correlation needs to shift toward using the more central part of the visual field [ 71 ].…”

Section: Central Serous Chorioretinopathymentioning

confidence: 99%

Selective and complementary use of Optical Coherence Tomography and Fluorescein Angiography in retinal practice

Shoughy

Kozák

2016

Eye and Vis

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The current field of posterior pole and retinal imaging of the human eye has expanded into detailed analyses of the macula, retinal periphery, individual retinal layers, vitreoretinal interface, imaging of the choroid and the optic nerve head. The challenge in retinal imaging is the enduring pursuit of deeper penetration into tissues, increased resolution to the cellular level, and interpretation of observations. How much deeper can we go and with what resolution and reproducibility? These are fundamental questions for experts in search of novel imaging modalities. New discoveries may resolve existing controversies, but inevitably stimulate new questions. Emerging technologies in retinal imaging include adaptive optics retinal imaging and optical coherence tomography-based retinal angiography.In this review, the focus of our discussion will be the discrepancy between the findings (interpretation) of one imaging technology that do not agree or are not even found with a complementary technology. If a clearly seen abnormality is present with one technology but absent in another, what are the possible explanations? Following is a summary of key concepts of retinal and optic nerve imaging modalities and current controversies regarding their interpretation and/or limitations.

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“…In 1998, Zeimer et al [ 4 ] first suggested imaging of the macula as a potential structure for the diagnosis of glaucoma, and it has now been widely demonstrated that thinning of the macula occurs in glaucoma as a result of the retinal ganglion cells (RGC) loss typical of this pathology [ 5 , 6 ]. Several authors have studied the correlation between perimetry and macular thickness [ 7 – 13 ]. Most of them used simple correlation and linear regression between global indices and by sectors.…”

Section: Introductionmentioning

confidence: 99%

Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry

Jaumandreu

Muñoz‐Negrete

Oblanca

et al. 2018

Journal of Ophthalmology

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Purpose To study the structure-function relationship in glaucoma and healthy patients assessed with Spectralis OCT and Humphrey perimetry using new statistical approaches. Materials and Methods Eighty-five eyes were prospectively selected and divided into 2 groups: glaucoma (44) and healthy patients (41). Three different statistical approaches were carried out: (1) factor analysis of the threshold sensitivities (dB) (automated perimetry) and the macular thickness (μm) (Spectralis OCT), subsequently applying Pearson's correlation to the obtained regions, (2) nonparametric regression analysis relating the values in each pair of regions that showed significant correlation, and (3) nonparametric spatial regressions using three models designed for the purpose of this study. Results In the glaucoma group, a map that relates structural and functional damage was drawn. The strongest correlation with visual fields was observed in the peripheral nasal region of both superior and inferior hemigrids (r = 0.602 and r = 0.458, resp.). The estimated functions obtained with the nonparametric regressions provided the mean sensitivity that corresponds to each given macular thickness. These functions allowed for accurate characterization of the structure-function relationship. Conclusions Both maps and point-to-point functions obtained linking structure and function damage contribute to a better understanding of this relationship and may help in the future to improve glaucoma diagnosis.

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Correlation Between Macular Thickness and Glaucomatous Visual Fields

Abstract: As a predictable and significant structural relationship exists between macular thickness and VF defects, macular scan OCT should be studied further and considered more carefully in the diagnosis and management of glaucoma.

Cited by 7 publications

References 8 publications

Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects

Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects

Selective and complementary use of Optical Coherence Tomography and Fluorescein Angiography in retinal practice

Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry

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