Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects

Abstract

Glaucomatous damage of the macula was common and more frequent in the inferior retina. GCIPL defect patterns as determined by SD-OCT imaging corresponded well with central VF defects. It seems macular GCIPL analysis may be useful for evaluating glaucomatous optic neuropathy.

Comparison of Two Different OCT Systems: Retina Layer Segmentation and Impact on Structure-Function Analysis in Glaucoma

“…A significant correlation between function (global MD) and morphology (MT [ 23 , 24 ] or GCIPL [ 20 , 25 , 26 ]) has been demonstrated previously. In agreement, despite the significant difference between Cirrus and Spectralis measurements, both OCTs demonstrated a significant positive association with global MD.…”

A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography

“…15–18 In cases of purely diffuse damage, a global measure may be more suitable. However, diffuse damage is often accompanied by local damage, and an ROI approach is useful in these patients.…”

Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses

“…[4][5][6][7][8][9] Although the use of optical coherence tomography (OCT) has grown in recent years, it is not clear how best to detect macular damage using OCT. Some have argued for using retinal ganglion cell plus inner plexiform layer (RGCþ), 7,8,10 or macular retinal nerve fiber layer (RNFL) 11 measurements from macular cube scans. However, for diagnosing and following glaucomatous damage, macular scans are not routinely obtained in many clinics.…”