Correlation Between Neonatal Cranial Ultrasound, MRI in Infancy and Neurodevelopmental Outcome in Infants with a Large Intraventricular Haemorrhage with or without Unilateral Parenchymal Involvement

Vries, L.S. de; Rademaker, Karin J; Groenendaal, Floris; Eken, P.; Haastert, Ingrid C. van; Vandertop, W. P.; Gooskens, R. H. J. M.; Meiners, Linda C.

doi:10.1055/s-2007-973558

Cited by 75 publications

(28 citation statements)

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“…44 Moreover, abnormalities of MRI signals from the posterior parietal periventricular crossroad in older preterm infants may have a prognostic value for evaluating the outcome of perinatal PVL. 45 Another interesting finding, frequently observed in survivors of very preterm birth 46,47 and after the perinatal PVL, [48][49][50] is the significant reduction of the corpus callosum. As callosal fibres represent a substantial component of periventricular crossroads, 3 it is not surprising that hypoxic-ischaemic lesions of the corpus callosum represent both an essential component of selective vulnerability of periventricular pathways as well as a frequent abnormality of corticocortical connections.…”

Section: Comparison Of Mri and Histological Findingsmentioning

confidence: 99%

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

Kostović

Judaš

2006

Develop Med Child Neuro

141

117

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The aim of this paper is to evaluate correlative magnetic resonance imaging (MRI) and histological parameters of development of cortical afferents during pathfinding and target selection in transient fetal cerebral laminas in human fetuses and preterm infants. The transient fetal subplate zone, situated between the fetal white matter (i.e. intermediate zone) and the cortical plate, is the crucial laminar compartment for development of thalamocortical and corticocortical afferents. The prolonged coexistence of transient (endogenously active) and permanent (sensorydriven) circuitry within the transient fetal zones is a salient feature of the fetal and preterm cortex; this transient circuitry is the substrate of cerebral functions in preterm infants. Another transient aspect of organization of developing fibre pathways is the abundance of extracellular matrix and guidance molecules in periventricular crossroads of projection and corticocortical pathways. Both the subplate zone and periventricular crossroads are visible on MRI in vivo and in vitro. Hypoxic-ischaemic lesions of periventricular crossroads are the substrate for motor, sensory, and cognitive deficits after focal periventricular leukomalacia (PVL). Lesions of distal portions of the white matter and the subplate zone are the substrate for diffuse PVL. The neuronal elements in transient fetal zones form a developmental potential for plasticity after perinatal cerebral lesions.Our understanding and interpretation of structural and functional consequences of cerebral lesions in human fetuses and preterm infants largely depends on knowledge of neurogenetic cellular events that can be demonstrated by in vivo neuroimaging. A necessary step in this approach is the correlation between magnetic resonance imaging (MRI) and histological organization during different phases of histogenesis. Namely, in the fetal cerebrum, early neurogenetic cellular events (i.e. proliferation, migration, aggregation, cell death, growth of axons, and the establishment of neuronal connections) proceed according to the specific timetable within transient, histologically recognizable fetal zones which do not have an equivalent in the adult brain. 1 During the last third of gestation, neuronal proliferation and migration are mostly completed 1 whereas the development of axonal pathways 2,3 and the differentiation of cortical neurons 4 become the most prominent neurogenetic events. Synaptogenesis continues as the dominant neurogenetic event during postnatal life. In addition to precise timing, these neurogenetic events also display a characteristic spatial occurrence: neuronal proliferation occurs in the ventricular and subventricular zones, whereas neuronal migration and growth of axons occur predominantly in the intermediate zone (the fetal white matter) and the subplate zone, which is situated between the intermediate zone and the cortical plate. 1 Neuronal differentiation and synaptogenesis begin in the transient subplate zone 5 and continue in the cortical plate. 1,5 Recent research in...

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Section: Comparison Of Mri and Histological Findingsmentioning

confidence: 99%

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

Kostović

Judaš

2006

Develop Med Child Neuro

141

117

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“…Consequent periventricular venous infarction is often hemorrhagic and may damage the descending corticospinal tracts, resulting in hemiparesis. 23 Previous studies have shown that periventricular venous infarction can occur also prenatally and can be detected in term born children. 16 In a case series supplied with a literature review of prenatally developed hemorrhages, the mean age of prenatal hemorrhages was 30 gestational weeks with a range of 20-37 weeks.…”

Section: Discussionmentioning

confidence: 99%

Presumed Perinatal Stroke

et al. 2015

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It is unknown why some infants with perinatal stroke present clinical symptoms late during infancy and will be identified as infants with presumed perinatal stroke. The risk factors and clinical and radiological data of 42 infants with presumed perinatal stroke (69% with periventricular venous infarction and 31% with arterial ischemic stroke) from the Estonian Pediatric Stroke Database were reviewed. Children with presumed perinatal stroke were born at term in 95% of the cases and had had no risk factors during pregnancy in 43% of the cases. Children with periventricular venous infarction were born significantly more often (82%) vaginally (P = .0213) compared to children with arterial stroke (42%); nor did they require resuscitation (P = .0212) or had any neurological symptoms after birth (P = .0249). Periventricular venous infarction is the most common type of lesion among infants with the presumed perinatal stroke. Data suggest that the disease is of prenatal origin.

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“…The clot itself may obscure the ventricle due to complete filling of the lumen. IVH may or may not be associated with an intra parenchymal haemorrhage [16].…”

Section: Pitfalls Of Usg Studymentioning

confidence: 99%

Ultrasonographic Evaluation of the Neonatal Brain in Cases of Birth Asphyxia

Giri¹

2016

IJARS

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Introduction: Hypoxic ischemic encephalopathy (HIE) is a common condition in newborns as a result of birth asphyxia. Affected neonates display a number of clinical features by which the condition may be suspected. Aim:To study the different varieties of gross anatomical defects of the neonatal brain in cases of HIE as seen by ultrasonography. Materials and Methods:Ultrasonography (USG) of the neonatal brain was done in 100 cases of hypoxic ischemic encephalopathy (HIE) during the first and second weeks of life, through anterior, posterior and mastoid fontanelles.The results were analysed to display the spectrum of abnormalities in the affected babies.Results: A large proportion of the neonates had a normal study (47%), followed by intracranial haemorrhage (24%), cerebral oedema and infarction (17%), dilatation of ventricles (5%), and others (7%). Conclusion:Intracranial haemorrhage is the commonest consequence of hypoxic ischemic encephalopathy. The large number of normal studies shows the need for combining ultrasonography with other imaging modalities in selected cases.Radiology Section

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Correlation Between Neonatal Cranial Ultrasound, MRI in Infancy and Neurodevelopmental Outcome in Infants with a Large Intraventricular Haemorrhage with or without Unilateral Parenchymal Involvement

Abstract: Combining neonatal US with MRI in infancy enhances our understanding of the long-term effects of severe haemorrhagic brain lesions, occurring in preterm infants.

Cited by 75 publications

References 1 publication

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

Presumed Perinatal Stroke

Ultrasonographic Evaluation of the Neonatal Brain in Cases of Birth Asphyxia

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