Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with parkinsonism

Kuya, Keita; Shinohara, Yuki; Miyoshi, Fumito; Fujii, Shinya; Tanabe, Yuji; Ogawa, Toshihide

doi:10.1007/s00234-016-1644-7

Cited by 39 publications

(37 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to age‐matched controls, PD patients showed reduced volume and contrast‐to‐noise‐ratio of the SNc, and both measurements, though SNc volume more than contrast ratio, showed a positive correlation with the corresponding striatal 123 I‐FP‐CIT binding. A similar significant correlation between SNc volume and striatal specific binding ratio of 123 I‐FP‐CIT has been reported in a cohort of 23 patients with parkinsonism (17 PD, 3 MSA, 1 PSP, 1 spinocerebellar degeneration, and 1 ET) . Taken together findings from these two studied suggest that loss of nigral neuromelanin is directly associated with loss/dysfunction of striatal dopamine presynaptic terminals and can be potentially used as a biomarker of nigrostriatal dysfunction.…”

Section: Neuromelanin Sensitive Mrisupporting

confidence: 78%

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Pavese

Tai

2018

Movement Disord Clin Pract

View full text Add to dashboard Cite

Background Recent developments in magnetic resonance imaging (MRI) techniques have offered new research opportunities to visualize in vivo substantia nigra pathology in Parkinson's disease (PD). This paper summarizes the main findings of nigrosome imaging and neuromelanin sensitive MRI studies in patients with PD and other parkinsonisms. Methods The PubMed database was searched from 2005 to 2017 using the following keywords: Parkinson's disease and parkinsonism, in combination with MRI, nigrosome, neuromelanin, and iron. Only publications in English were included. Results Nigrosome or dorsal nigral hyperintensity abnormalities are studied using T2* and susceptibility weighted imaging MRI sequences in most studies, whereas Neuromelanin imaging is usually performed using T1‐weighted fast spin echo sequence. Nigrosome abnormalities have been consistently demonstrated in PD patients, and nigrosome imaging has high sensitivity and specificity in distinguishing PD from healthy controls, though it is unable to reliably separate PD from atypical parkinsonisms. Reduced neuromelanin‐related signals and/or volume loss in neuromelanin containing structures have been found in PD patients, and neuromelanin sensitive MRI imaging can also discriminate PD patients from healthy controls with high accuracy, though there is a degree of heterogeneity in the imaging findings. Preliminary findings suggested that longitudinal change of neuromelanin signal could be detected in PD, raising the possibility of using it as a marker of disease progression. Conclusion Nigrosome imaging and neuromelanin sensitive MRI are promising tools to study nigral pathology and to improve the diagnosis of PD. However, further studies are required to standardize analysis approaches, confirm longitudinal changes, and assess their generalizability.

show abstract

Section: Neuromelanin Sensitive Mrisupporting

confidence: 78%

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Pavese

Tai

2018

Movement Disord Clin Pract

View full text Add to dashboard Cite

show abstract

“…Sasaki et al . reported that the paramagnetic T1 shortening area in NM‐MRI was clearly correlated with NM‐SNc in gross specimens, suggesting that the high signal intensity areas corresponded to NM‐containing neurons . Colloby et al .…”

Section: Discussionmentioning

confidence: 96%

“…Previous neuropathological studies reported an association between the number of surviving NM‐containing neurons and the functional state of those neurons’ axon terminals . Therefore, NM‐SNc may predict not only the number of dopaminergic neurons but also the terminal function . Furthermore, PD pathology occurs asymmetrically and motor symptoms manifest unilaterally.…”

Section: Discussionmentioning

confidence: 99%

“…Specific fast spin‐echo T1‐weighted magnetic resonance imaging (MRI) at 3 Tesla (neuromelanin MRI; NM‐MRI) can detect neuromelanin in dopaminergic neurons in the SNc . Kuya et al .…”

Section: Introductionmentioning

confidence: 99%

“…Kuya et al . reported a significant correlation between the size of the NM‐positive SNc area (NM‐SNc) on NM‐MRI and the mean putaminal specific binding ratio (SBR) on DaT‐SPECT. Therefore, both neuroimaging tools might be useful for monitoring and evaluating dopaminergic neuronal degeneration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuromelanin or DaT‐SPECT: which is the better marker for discriminating advanced Parkinson's disease?

Okuzumi

Hatano

Kamagata

et al. 2019

Euro J of Neurology

View full text Add to dashboard Cite

Background and purposeWhether the neuromelanin‐positive substantia nigra pars compacta area (NM‐SNc) on neuromelanin magnetic resonance imaging (NM‐MRI) and the specific binding ratio (SBR) on 123I‐N‐v‐fluoropropyl‐2b‐carbomethoxy3b‐(4‐iodophenyl)nortropane single photon emission computed tomography (DaT‐SPECT) can be correlated with motor fluctuations (MFs) in advanced Parkinson's disease (PD) was investigated.MethodsThirty‐five PD patients (60 ± 13 years) and 23 healthy individuals as controls (59 ± 19 years) were enrolled. The relationships between NM‐MRI and DaT‐SPECT were prospectively examined in two subgroups divided according to the presence or absence of MFs. Multivariate analysis was performed using the Cox proportional hazard model to screen for association factors.ResultsThe NM‐SNc size was correlated with the SBR (Spearman's ρ = 0.43, P < 0.05). The NM‐SNc size was significantly reduced in PD with MFs compared with the subgroup without (P < 0.001), whereas the SBR did not significantly differ between the groups. NM‐SNc size was a significant association factor for MFs (hazard ratio 0.94, P = 0.04). In receiver operating characteristic analysis of the factors for MF occurrence, the area under the receiver operating characteristic curve of the NM‐SNc size showed a significant difference of 0.89 (P < 0.05) but no significant difference was found in the SBR.ConclusionsNM‐SNc size was significantly correlated with the SBR in PD, but several factors in advanced PD were more closely associated with NM‐SNc size than the SBR. NM‐MRI might reflect the status of advanced PD more accurately than DaT‐SPECT. Therefore, NM‐MRI appears to provide a better marker for discriminating advanced PD than DaT‐SPECT.

show abstract

Magnetic Susceptibility Associates With Dopaminergic Deficits and Cognition in Parkinson's Disease

et al. 2020

View full text Add to dashboard Cite

The objective of this study was to assess the relationship between nigrostriatal magnetic susceptibility and dopamine transporter abnormality and their associations with behavioral and cognitive impairments in patients with Parkinson's disease (PD). Methods: For this case-control study, we enrolled 41 patients with PD and 20 age-matched healthy controls. All participants underwent global physical and cognitive assessments, 3-Tesla brain magnetic resonance imaging including quantitative susceptibility mapping (QSM; iron deposition measure), and 123 IN -v-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane single-photon emission computed tomography (dopamine transporter measure). We subdivided the striatum into the putamen, caudate nucleus, and nucleus accumbens and measured the nigrostriatal QSM values and dopamine transporterspecific binding ratios using an atlas-based approach. Results: The patients with PD had higher QSM values in the substantia nigra and subdivisions of the striatum than did the healthy controls. The striatal dopamine transporter-specific binding ratios were not correlated with the QSM values of the substantia nigra but were inversely correlated with those of the striatum (putamen, r = −0.478, P = 0.009; caudate nucleus, r = −0.462, P = 0.011). The QSM values of the putamen were positively correlated with motor parkinsonism scores (Movement Disorder Society Unified Parkinson's Disease Rating Scale, r = 0.505, P = 0.003), and those of the caudate nucleus were negatively correlated with cognitive impairment scores (Montreal Cognitive Assessment, r = −0.525, P < 0.001). Conclusions: This study showed that striatal iron accumulations were correlated with dopaminergic deficits and neurophysiological signs in patients with PD, highlighting the potential of QSM as an auxiliary biomarker for parkinsonism and cognitive dysfunction.

show abstract

Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with parkinsonism

Abstract: Decrease of the high signal intensity region of the SNc on neuromelanin-sensitive MRI would indicate damage to the nigrostriatal dopaminergic function as well as loss of dopaminergic neurons. We conclude that neuromelanin-sensitive MRI is a useful diagnostic biomarker for parkinsonism.

Cited by 39 publications

References 36 publications

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Nigrosome Imaging and Neuromelanin Sensitive MRI in Diagnostic Evaluation of Parkinsonism

Neuromelanin or DaT‐SPECT: which is the better marker for discriminating advanced Parkinson's disease?

Magnetic Susceptibility Associates With Dopaminergic Deficits and Cognition in Parkinson's Disease

Contact Info

Product

Resources

About