Correlation between neutrophil/lymphocyte ratio and Ranson score in acute pancreatitis

Abaylı, Bahri; Gençdal, Genco; Değirmencioğlu, Şerife

doi:10.1002/jcla.22437

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…A few studies have investigated the relationship between NLR and outcome in patients with AP. Abaylı et al analyzed 435 patients with AP and found that NLR was greater in the group with a Ranson score ≥3 than the group with a Ranson score <3; thus, he concluded that NLR was a simple, practical, and effective marker for diagnosis of AP severity compared with current scoring systems. O'Connell et al revealed that NLR above five increased the risk of ICU admission.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Huang

Chen

Yang

et al. 2019

Clinical Laboratory Analysis

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Objectives We aimed to evaluate the values of neutrophil‐to‐lymphocyte ratio (NLR) and white blood cell (WBC) in predicting severity of acute pancreatitis (AP) with different etiologies. Methods We compared NLR and WBC levels in patients with different etiologies and AP severity. The optimal cutoff value for them to predict severe acute pancreatitis (SAP) was determined by receiver operating characteristic (ROC) curve analysis. Results Both NLR and WBC were elevated in patients with SAP. After subgrouping AP by etiology, NLR was predictive of SAP only in hypertriglyceridemia‐induced AP (HTG‐AP), while WBC could effectively predict severity in both gallstone and HTG‐AP. The best cutoff value of WBC for predicting SAP in gallstone AP patients was 12.81 × 109/L, with sensitivity and specificity of 78.9% and 70.2%. The best cutoff value for NLR and WBC to differentiate HTG‐SAP was more than 5.88 and 15.89 × 109/L, respectively, with sensitivity and specificity of 87% and 50% for NLR and 56.5% and 75.76% for WBC. Conclusions Our study firstly demonstrated that NLR selectively played a role in HTG‐AP, while WBC could predict the severity of both gallstone and HTG‐AP. Furthermore, we firstly elucidated that NLR was more sensitive and accurate in judging the severity of HTG‐AP compared with WBC.

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Section: Discussionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Huang

Chen

Yang

et al. 2019

Clinical Laboratory Analysis

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“…Huang et al demonstrated that NLR is more sensitive and accurate than WBC in determining the severity of HTG-AP [18]. Abayli and Gencdal conducted a correlation study between the NLR and Ranson score on 435 AP patients and found that NLR is a simpler, more practical, and effective parameter for diagnosing the severity of AP compared with the current scoring system [22]. Li et al showed that compared with PNI, CRP, RDW, and LMR, the NLR is the most powerful indicator of overall survival and has the highest prognostic value in AP patients [9].…”

Section: Disease Markersmentioning

confidence: 99%

Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis

Kong

Bao

et al. 2020

Disease Markers

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Background. Acute pancreatitis (AP) is a life-threatening disease caused by a variety of factors, and once it progresses to severe acute pancreatitis, the prognosis is poor. The purpose of this study was to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR) for predicting the severity of acute pancreatitis. Materials and Methods. We searched the databases of PubMed, EMBASE, Web of Science, and Cochrane Library to identify eligible studies using the NLR to predict the severity of AP. The sensitivity (SEN), specificity (SPE), negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were combined using a bivariate mixed model. Results. A total of 10 articles containing 394 cases and 1319 controls were included in the study. The combined SEN, SPE, NLR, PLR, DOR, and AUC are 79% (73%-84%), 71% (59%-80%), 0.30 (0.21-0.41), 2.7 (1.8-4.0), 9 (5-18), and 0.82 (0.78-0.85), respectively. Conclusions. NLR has a moderately high diagnostic value in predicting the severity of acute pancreatitis.

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“…Furthermore, it is easy to obtain NLR and is less affected by physiological factors and specimen treatment [ 9 ]. Recent studies have found that NLR is closely related to the occurrence, severity, and prognoses of many acute diseases, such as acute coronary syndrome [ 10 ], acute ischemic stroke (AIS) [ 11 ], acute pancreatitis [ 12 ], acute respiratory distress syndrome [ 13 ], acute appendicitis [ 14 ], and acute type A aortic dissection [ 15 ]. During the development of systemic inflammatory response, WBCs are the effector cells of inflammatory response and the effector mediator of inflammatory conduction.…”

Section: Introductionmentioning

confidence: 99%

Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells

Cheng

Zhou

et al. 2021

Open Life Sciences

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The role of inflammation has been identified in the pathogenesis of diabetic ketoacidosis (DKA). The neutrophil/lymphocyte ratio (NLR) and white blood cells (WBC) can be used to predict a systemic inflammatory response. Changes in NLR and WBC levels have never been explored in type 1 diabetes mellitus (T1DM) patients with DKA and an uninfected state. This retrospective study included a total of 644 participants. NLR and WBC were measured in the control group (n = 316) and in T1DM patients with mild-DKA (n = 92), severe-DKA (n = 52), and non-DKA (n = 184) in an uninfected state. Then, we assessed the independent predictors of DKA occurrence in T1DM patients in an uninfected state. The diagnostic performance of variables was determined by receiver operating characteristic curve analysis. Serum NLR of T1DM patients is significantly higher than that of normal controls, and if DKA occurs, NLR increases further and increases with the severity of DKA. In addition to diastolic blood pressure, blood urea nitrogen, glycated hemoglobin (HbA1c), and WBC, NLR was also independently associated with DKA in T1DM patients with an uninfected state (OR = 1.386, 95% CI: 1.127–1.705, p = 0.002). Furthermore, the diagnosis analysis showed that except for NLR and WBC, the area under the curve (AUC) of indicators with a statistical difference in patients with and without DKA were 0.747 for DKA diagnosis, and after the addition of NLR and WBC, the AUC was 0.806. The increased NLR level represents a low-cost and highly accessible predictor for DKA in T1DM patients with an uninfected state. The addition of inflammation indicators can play a statistically significant role in the prediction model of the DKA occurrence.

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Correlation between neutrophil/lymphocyte ratio and Ranson score in acute pancreatitis

Abstract: Quick diagnosis is essential in AP. Current scoring systems for AP diagnosis are complicated, whereas NLP is a simple, practical, and effective marker.

Cited by 16 publications

References 18 publications

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis

Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells

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