Background: The prevalence of coronary heart disease (CHD) is increasing worldwide. The main purpose of this study was to investigate the prevalence of CHD and related risk factors in the population of Shahedieh cohort in Yazd, central Iran.Method: This cross-sectional analytical study was performed on the data of the first phase of the Yazd Shahedieh cohort study, which started in 2016 and included about 10,000 people from the urban population of 35-70 years old in Yazd Shahedieh – Yazd, Iran. Descriptive statistics were used to describe the variables and Chi-square test and multiple binary logistic regression models were used for analysis by reporting the modified odds ratio. All analyzes were performed in SPSS 19 software with a significance level of 5%. Results: The prevalence of the CHD was 8.08% (769 patients). The results of multiple binary logistic regression identified aging, low level of education, smoking, female gender, abnormal LDL, family history, diabetes and blood pressure as risk factors for CHD. The odds of getting CHD over the age of 60 was about 6 times than those aged 30-40, in the illiterate people it was about two times than the university. Smoking, family history, hypertension and diabetes increased the odds of getting CHD by 1.67, 1.59, 3.48 and 1.64. Smoking, family history, hypertension and diabetes increased the odds of getting CHD by 1.67, 1.59, 3.48 and 1.64, times than others, respectively.Conclusion: The prevalence of the disease in Iran was relatively high. According to the effect size, the most important risk factors for the disease were age over sixty years and blood pressure.