Correlation between Obstructive Sleep Apnea Syndrome and Cardiac Disease Severity

Abstract

Background. Obstructive sleep apnea (OSA) syndrome is one of the most common respiratory disorders in humans. There is emerging evidence linking OSA to vascular disease, particularly hypertension. The underlying pathophysiological mechanisms that link OSA to cardiovascular diseases such as hypertension, congestive heart failure, and atrial fibrillation are not entirely understood. The aim of this study was to investigate the association of obstructive sleep apnea hypopnea syndrome (OSAHS) with coronary atherosclerotic disease (CAD). Methods. A questionnaire survey based on Berlin questionnaire and Epworth Sleepiness Scale (ESS) was conducted among 406 patients to assess demographic data and the symptoms, such as excessive daytime sleepiness and snoring. Epworth Sleepiness Scale and Berlin questionnaire were completed by all of the patients. Venous blood samples were obtained for biochemical tests. Characteristics of coronary arteries were collected from angiographies' reports. All patients were divided into two groups based on results from Berlin questionnaire: low risk patients for OSA and high risk patients for OSA. Data were analyzed by SPSS software version 13. Results. Mean age of patients was 61.8 ± 10.5. 212 (52.2%) patients were categorized as high risk group for apnea. Also, excessive daytime sleepiness was reported in 186 patients (45.8%). The severity of coronary artery involvement, daytime sleepiness, and electrocardiogram abnormalities was significantly higher in high risk patients for OSA compared with low risk patients. High risk patients had higher level of FBS and LDL and lower level of HDL cholesterol (P < 0.05). Conclusion. Our study found a strong correlation between the number of stenotic vessels and OSA. Based on our findings, OSA can be a predisposing factor for cardiac diseases.

Probability of obstructive sleep apnea in male patients with systolic heart failure and some related factors

“…Probably the difference between the findings can be due to the kind of study, the age of the subjects, selecting only males, and suffering from a systolic kind of heart failure in the current study and the difference in OSA evaluation method. Change and increase in the probability of OSA was observed in older patients more than in the younger ones (35). Probably poor function of muscles of holding the airway open has a role in increasing apnea in the aged people.…”

HIV-Associated Neurocognitive Disorders: The Relationship of HIV Infection with Physical and Social Comorbidities

“…The literature on sleep and HIV and neurocognition had focused on the CNS effects of efavirenz but this effect on sleep and neurocognition can be variable in duration [ 147 ]. Sleep disorders are also associated with other medical conditions including metabolic syndrome and cardiovascular disease [ 148 – 152 ]. The synergistic effect of sleep disorders and cardiovascular and metabolic complications on neurocognition in HIV patients has not been reported extensively.…”

The Importance of Proximal RCA Stenosis is Associated with Severe OSAS Patients

“…In an another study conducted on patients with acute coronary syndrome, more chronic total occlusion lesions were detected in OSAS patients compared to patients without OSAS [19]. It has been reported that multivessel disease and coronary artery calcification are more common in OSAS patients [20][21][22]. In our study we investigated whether there is a specific relationship between SX score and OSAS patients and coronary segments.…”