Correlation between Ocular Manifestations and Their Complications as Opposed to Visual Acuity and Treatment in Behcet's Disease

Paović, Jelena; Paović, Predrag; Sredovic, Vojislav

doi:10.1155/2013/842673

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…It is noteworthy that the literature encloses some controversial studies regarding the correlation between macular thickness and visual acuity. Several studies reported moderate to strong correlations between macular thickness and visual acuity, however, some reported weak or no correlation 9 , 10 , 11 , 12 , given the fact that the alterations or disruption of particular retinal sublayers, including ORL, may be associated with visual acuity.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography – A Predictor of Visual Acuity in Schizophrenia

Bozali

Yalınbaş

2022

Klin Monbl Augenheilkd

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Background The aim of this study was to evaluate the thickness of the outer retinal layer (ORL) together with macular thickness and changes in the retinal nerve fiber layer (RNFL) in patients with schizophrenia in comparison with healthy controls. Methods This study included 114 eyes of 57 patients diagnosed with schizophrenia and 114 eyes of 57 healthy controls. Central foveal thickness (CFT), central macular thickness (CMT), and ORL thickness were measured in both groups via the images obtained by spectral-domain optical coherence tomography (SD-OCT). RNFL was also assessed in four quadrants (inferior, superior, temporal, nasal). CMT measurements were presented as the average thickness of the macula in the central 1 mm area on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. The ORL thickness was defined as the distance between the external limiting membrane and retinal pigment epithelium at the center of the foveal pit. Results The mean age of 57 patients was 37 ± 10 years, of whom 34 (60%) were male and 23 (40%) female. No statistically significant difference was found between groups in terms of age and gender (p = 0.8 for age, p = 0.9 for gender). There was no statistically significant difference in the mean CMT between the two groups (p = 0.1). The mean ORL thickness in the two groups was 99.8 ± 8.3 and 103.7 ± 6.2, respectively, and was significantly decreased in the schizophrenia group (p = 0.005). RNFL analysis demonstrated significant thinning in the inferior and superior quadrants compared to healthy controls (p < 0.001 and p = 0.017, respectively). Conclusions SD-OCT findings – especially ORL and RNFL thickness – may be related to the neurodegenerational changes in schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography – A Predictor of Visual Acuity in Schizophrenia

Bozali

Yalınbaş

2022

Klin Monbl Augenheilkd

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“…[ 6 7 8 ] Previous studies have reported many systemic treatments with limited success in improving VA (8.8–24.8%) in BD with ocular involvement. [ 9 10 11 12 13 14 15 ]…”

Section: Introductionmentioning

confidence: 99%

Characteristics of macular edema in behcet disease after intravitreal bevacizumab injection

Ghassemi

Mirak

Chams

et al. 2017

J Ophthalmic Vis Res

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Purpose:To investigate the effect of intravitreal bevacizumab (IVB) injection on macular edema (ME) secondary to Behcet's disease.Methods:This prospective case series included 15 patients with bilateral ME due to Behcet's disease. Intravitreal bevacizumab was injected into the more severely involved eye; the contralateral eye was evaluated as the control. Patients were followed up with comprehensive ocular examination, optical coherence tomography, and fluorescein angiography (FA) for a minimum of 6 months by a single ophthalmologist.Results:Patients with a mean age of 30.6 ± 7.4 years received a mean number of 3.3 IVB injections during the 6 months. The mean preinjection vision was 0.6 ± 0.3 and 0.4 ± 0.4 LogMAR in the case and control groups, respectively, with no significant improvement at 6 months. Mean central foveal thickness was 375.3 ± 132.1 and 307.2 ± 84.5 μm in the case and control groups, respectively, and these changed to 401 ± 199.9 (P = 0.65) and 307.7 ± 82.8 μm (P = 0.73) at month 6, respectively. A statistically nonsignificant improvement in ME was observed during the first 3 months in the case group. However, it did not persist up to month 6 on an as-needed basis. IVB injections caused a disproportionate decrease in the thickness of macular subfields. A reduction in disc leakage was observed on FA (P = 0.058). Logistic regression analysis revealed no statistically significant predictive factor for an improvement in visual acuity (VA) and a reduction in foveal thickness.Conclusion:During a 6-month period, IVB injections based on an as-needed protocol provided no statistically significant improvement in VA and ME.

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“…Classically it presents with a triad of oral aphthous ulcers, genital ulcers, and uveitis. Nevertheless, it can also compromise other systems and organs less frequently, such as the central nervous system, cardiovascular, skin, gastrointestinal, renal, pulmonary, and musculoskeletal systems [1][2][3][4].…”

mentioning

confidence: 99%

“…The prevalence of BD varies with demographic profiles and is determined by environmental and genetic factors [2]. Turkey has the highest prevalence of BD, with 420 per 10,000 inhabitants [1,5].…”

mentioning

confidence: 99%

Swept-source optical coherence tomography angiography findings in a patient with Behçet’s disease: a case report

Bueso-Ponce¹,

Rivera-Valdivia²,

Salgado-Cerrate³

et al. 2021

Ophthalmol J

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Behçet's disease (BD), also known as "silk road disease" [1], was first described in 1937 [2]. This multisystemic rheumatologic disease is characterized by necrotizing, chronic, and occlusive vasculitis, of unknown cause, which affects arteries and veins, with recurrent self-limited episodes [1-3]. Classically it presents with a triad of oral aphthous ulcers, genital ulcers, and uveitis. Nevertheless, it can also compromise other systems and organs less frequently, such as the central nervous system, cardiovascular, skin, gastrointestinal, renal, pulmonary, and musculoskeletal systems [1][2][3][4].

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Correlation between Ocular Manifestations and Their Complications as Opposed to Visual Acuity and Treatment in Behcet's Disease

Cited by 6 publications

References 36 publications

Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography – A Predictor of Visual Acuity in Schizophrenia

Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography – A Predictor of Visual Acuity in Schizophrenia

Characteristics of macular edema in behcet disease after intravitreal bevacizumab injection

Swept-source optical coherence tomography angiography findings in a patient with Behçet’s disease: a case report

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