Correlation between pairing initiation sites, recombination nodules and meiotic recombination in Sordaria macrospora.

Zickler, Denise; Moreau, Patrick J. F.; Huynh, Anh Dao; Slézec, Anne-Marie

doi:10.1093/genetics/132.1.135

Cited by 98 publications

(18 citation statements)

References 55 publications

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“…Since SICs assemble prior to SC formation and are still present in a zip1 mutant where SC is absent, Fung et al (2004) concluded that interference in budding yeast can act independently of synapsis. This independence has also been shown in Sordaria (Zickler et al, 1992). A 2006 study showed substantial interference between MSH4 foci in mice with defective SCs, although the data did not allow determination of whether MLH1 foci interfere in the absence of the SC (de Boer et al, 2006).…”

Section: Synaptonemal Complexmentioning

confidence: 77%

Meiotic Crossover Patterning

Pazhayam

Turcotte

Sekelsky

2021

Front. Cell Dev. Biol.

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Proper number and placement of meiotic crossovers is vital to chromosome segregation, with failures in normal crossover distribution often resulting in aneuploidy and infertility. Meiotic crossovers are formed via homologous repair of programmed double-strand breaks (DSBs). Although DSBs occur throughout the genome, crossover placement is intricately patterned, as observed first in early genetic studies by Muller and Sturtevant. Three types of patterning events have been identified. Interference, first described by Sturtevant in 1915, is a phenomenon in which crossovers on the same chromosome do not occur near one another. Assurance, initially identified by Owen in 1949, describes the phenomenon in which a minimum of one crossover is formed per chromosome pair. Suppression, first observed by Beadle in 1932, dictates that crossovers do not occur in regions surrounding the centromere and telomeres. The mechanisms behind crossover patterning remain largely unknown, and key players appear to act at all scales, from the DNA level to inter-chromosome interactions. There is also considerable overlap between the known players that drive each patterning phenomenon. In this review we discuss the history of studies of crossover patterning, developments in methods used in the field, and our current understanding of the interplay between patterning phenomena.

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Section: Synaptonemal Complexmentioning

confidence: 77%

Meiotic Crossover Patterning

Pazhayam

Turcotte

Sekelsky

2021

Front. Cell Dev. Biol.

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“…It must be emphasized that, unlike noteworthy cases in yeast (ENGEBRECHT et al 1990) and Sordaria (ZICKLER et al 1992) which have been studied, the close rela-tionship of homologous synapsis here to the occurrence of crossing over is strictly a relationship to reciprocal recombination, not conversion, although many of the crossovers may also be associated with conversion. However, strong relationship of existence of overall homologous synapsis to conversion only events has been found in the mer1 mutant of yeast in cases where some of the usual defects are corrected by presence of the MER2 gene in high copy number.…”

Section: Discussionmentioning

confidence: 78%

“…At zygotene in material with large chromosomes, initiation of meiotic pairing and synapsis are accompanied by the appearance of SC-associated nodules which are generally smaller and much more numerous but otherwise appear similar to pachytene RNs (ALBINI andJoms 1987; . Some studies have suggested correlation between pairing initiation sites and positions of RNs, chiasmata and recombination (ZICKLER et al 1992;STACK et al 1993). ZICKLER et al (1992) found correlations between frequency and location of reciprocal exchanges and frequency and location of late RNs in wild-type Sordaria but disparity between location of nodules and exchanges in those mutants which cause reduction in recombination but do not cause SC arrest or major abnormalities.…”

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confidence: 99%

The relationship of homologous synapsis and crossing over in a maize inversion.

Maguire¹,

Riess²

1994

Genetics

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Frequency of homologous synapsis at pachytene for a relatively short heterozygous inversion was compared to the frequency of crossover occurrence within the inversion and to the frequency of the presence of a recombination nodule within the homologously synapsed inverted region. Crossover frequencies were estimated from bridge-fragment frequencies at anaphase I and anaphase II. Recombination nodules (RNs) were observed in electron micrographs. Results show very similar frequencies of homologous synapsis and the occurrence of reciprocal recombination within the inverted region, consistent with the interpretation that establishment of homologous synapsis in this case is related to at least commitment to the form of resolution of crossover intermediates which gives rise to reciprocal recombination, not conversion only, events. An RN was generally found at pachytene in homologously synapsed inverted regions.

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“…These models are compatible with the nonequivalence observed for the translocation chromosomes in C. elegans, if one postulates that the HRR pairs homologs from a distance, followed by DNA homology searches to promote synapsis and synaptonemal complex formation based on DNA sequence. Alternatively, the HRR could be required following a DNA homology search, perhaps as the region where synapsis initiates (e.g., ZICKLER et al 1992). If the HRR were a loading site for synaptonemal complex or recombination proteins, translocations and insertions might be expected to suppress recombination by blocking the progression of the complex.…”

Section: Discussionmentioning

confidence: 99%

Two types of sites required for meiotic chromosome pairing in Caenorhabditis elegans.

McKim¹,

Peters²,

Rose³

1993

Genetics

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Previous studies have shown that isolated portions of Caenorhabditis elegans chromosomes are not equally capable of meiotic exchange. These results led to the proposal that a homolog recognition region (HRR), defined as the region containing those sequences enabling homologous chromosomes to pair and recombine, is localized near one end of each chromosome. Using translocations and duplications we have localized the chromosome I HRR to the right end. Whereas the other half of chromosome I did not confer any ability for homologs to pair and recombine, deficiencies in this region dominantly suppressed recombination to the middle of the chromosome. These deletions may have disrupted pairing mechanisms that are secondary to and require an HRR. Thus, the processes of pairing and recombination appear to utilize at least two chromosomal elements, the HRR and other pairing sites. For example, terminal sequences from other chromosomes increase the ability of free duplications to recombine with their normal homologs, suggesting that telomere-associated sequences, homologous or nonhomologous, play a role in facilitating meiotic exchange. Recombination can also initiate at internal sites separated from the HRR by chromosome rearrangement, such as deletions of the unc-54 region of chromosome I. When crossing over was suppressed in a region of chromosome I, compensatory increases were observed in other regions. Thus, the presence of the HRR enabled recombination to occur but did not determine the distribution of the crossover events. It seems most likely that there are multiple initiation sites for recombination once homolog recognition has been achieved.

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Correlation between pairing initiation sites, recombination nodules and meiotic recombination in Sordaria macrospora.

Cited by 98 publications

References 55 publications

Meiotic Crossover Patterning

Meiotic Crossover Patterning

The relationship of homologous synapsis and crossing over in a maize inversion.

Two types of sites required for meiotic chromosome pairing in Caenorhabditis elegans.

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