Correlation between Patient-Reported Symptoms and Ankle-Brachial Index after Revascularization for Peripheral Arterial Disease

Abstract

Improvement in quality of life (QoL) is a primary treatment goal for patients with peripheral arterial disease (PAD). The current study aimed to quantify improvement in the health status of PAD patients following peripheral revascularization using the peripheral artery questionnaire (PAQ) and ankle-brachial index (ABI), and to evaluate possible correlation between the two methods. The PAQ and ABI were assessed in 149 symptomatic PAD patients before, and three months after peripheral revascularization. Mean PAQ summary scores improved significantly three months after revascularization (+49.3 ± 15 points, p < 0.001). PAQ scores relating to patient symptoms showed the largest improvement following revascularization. The smallest increases were seen in reported treatment satisfaction (all p’s < 0.001). As expected the ABI of treated limbs showed significant improvement post-revascularization (p < 0.001). ABI after revascularization correlated with patient-reported changes in the physical function and QoL domains of the PAQ. Twenty-two percent of PAD patients were identified as having a poor response to revascularization (increase in ABI < 0.15). Interestingly, poor responders reported improvement in symptoms on the PAQ, although this was less marked than in patients with an increase in ABI > 0.15 following revascularization. In conclusion, data from the current study suggest a significant correlation between improvement in patient-reported outcomes assessed by PAQ and ABI in symptomatic PAD patients undergoing peripheral revascularization.

Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community

“…Staying physically active is an important goal for older adults as a determinant of the ability to sustain independent living. Because several lifestyle (eg, smoking cessation or supervised exercise) or medical (eg, cilostazol or revascularization) interventions have demonstrated improvement in physical function among patients with PAD,45, 46, 47 it seems important to identify the contribution of PAD to the reduction of physical components of QOL in older adults. It is important to keep in mind that reduced QOL was also observed in those with borderline low ABI (<1.00) in our study.…”

Rivaroxaban plus aspirin for the prevention of ischaemic events in patients with cardiovascular disease: a cost-effectiveness study

“…The transition probability to ‘moderate PAD’ was calculated from the probability of MALE, multiplied with the proportion of acute and chronic limb ischaemia from COMPASS; 22% of these patients transitioned to ‘moderate PAD. 15 The transition probability to ‘severe PAD’ was calculated from the number of major vascular amputations and the population at risk in COMPASS, assumed to be patients with a revascularisation history ( Tables 1 and 2 in Anand et al.). 1 No data were available to model PAD progression on clopidogrel, therefore probabilities were assumed equal to aspirin.…”

Association between health status and long‐term mortality after percutaneous revascularization of peripheral artery disease

“…After 2 years of follow-up among 364 patients following an unscripted management plan for PAD, including a low rate of revascularization (18.9%), 36% were deemed treatment nonresponders with <5-point improvement in PAQ summary score. In another study, Je et al studied PAQ summary score change among 149 patients that underwent endovascular (n ¼ 100) and open surgical (n ¼ 49) revascularization for symptomatic PAD [23]. Among the study cohort, 22% failed to achieve an improvement in ABI !…”