Correlation between periodontal disease and oral cancer risk: A meta-analysis

Ye, Lili; Jiang, Yushi; Liu, Weidong; Tao, Hai-Biao

doi:10.4103/0973-1482.200746

Cited by 60 publications

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“…Different from all-cause death, the definite relevance between periodontal disease and cardiovascular mortality in CKD people is not observed in the present meta-analysis, which excludes the mechanism that elevated all-cause mortality is mediated by cardiovascular disease progression. A large number of publications have suggested that periodontal disease correlated significantly with death from various kinds of cancer [ 60 , 61 ], diabetes [ 62 ], and respiratory disease [ 63 , 64 ]. In addition, the study by Ruokonen also revealed that noncardiovascular systemic diseases, such as infection, and malignant disease were the main causes of death among CKD populations, which show significant association with periodontal disease [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies

et al. 2017

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AbstractsBackgroundPeriodontal disease occurs relatively prevalently in people with chronic kidney disease (CKD), but it remains indeterminate whether periodontal disease is an independent risk factor for premature death in this population. Interventions to reduce mortality in CKD population consistently yield to unsatisfactory results and new targets are necessitated. So this meta-analysis aimed to evaluate the association between periodontal disease and mortality in the CKD population.MethodsPubmed, Embase, Web of Science, Scopus and abstracts from recent relevant meeting were searched by two authors independently. Relative risks (RRs) with 95% confidence intervals (CIs) were calculated for overall and subgroup meta-analyses. Statistical heterogeneity was explored by chi-square test and quantified by the I2 statistic.ResultsEight cohort studies comprising 5477 individuals with CKD were incorporated. The overall pooled data demonstrated that periodontal disease was associated with all-cause death in CKD population (RR, 1.254; 95% CI 1.046–1.503; P = 0.005), with a moderate heterogeneity, I2 = 52.2%. However, no evident association was observed between periodontal disease and cardiovascular mortality (RR, 1.30, 95% CI, 0.82–2.06; P = 0.259). Besides, statistical heterogeneity was substantial (I2 = 72.5%; P = 0.012). Associations for mortality were similar between subgroups, such as the different stages of CKD, adjustment for confounding factors. Specific to all-cause death, sensitivity and cumulative analyses both suggested that our results were robust. As for cardiovascular mortality, the association with periodontal disease needs to be further strengthened.ConclusionsWe demonstrated that periodontal disease was associated with an increased risk of all-cause death in CKD people. Yet no adequate evidence suggested periodontal disease was also at elevated risk for cardiovascular death.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-017-0680-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies

et al. 2017

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“…CP patients are at substantial risk for developing deadly oral cancers, 90% of which are recurrent OSCC having less than 50% survival rate 5 , 6 . It has been denoted that patients with CP are more susceptible to poorly differentiated OSCC than those without periodontitis, thus indicating the association of periodontal disease with the development as well as advancement of oral cancers 7 , 8 . A recent cohort study emphasizes the role of periodontal disease in incident cancer risk among postmenopausal women 9 .…”

Section: Introductionmentioning

confidence: 99%

Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation

Arjunan

Meghil

et al. 2018

Sci Rep

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Chronic periodontitis (CP) is a microbial dysbiotic disease linked to increased risk of oral squamous cell carcinomas (OSCCs). To address the underlying mechanisms, mouse and human cell infection models and human biopsy samples were employed. We show that the ‘keystone’ pathogen Porphyromonas gingivalis, disrupts immune surveillance by generating myeloid-derived dendritic suppressor cells (MDDSCs) from monocytes. MDDSCs inhibit CTLs and induce FOXP3 + Tregs through an anti-apoptotic pathway. This pathway, involving pAKT1, pFOXO1, FOXP3, IDO1 and BIM, is activated in humans with CP and in mice orally infected with Mfa1 expressing P. gingivalis strains. Mechanistically, activation of this pathway, demonstrating FOXP3 as a direct FOXO1-target gene, was demonstrated by ChIP-assay in human CP gingiva. Expression of oncogenic but not tumor suppressor markers is consistent with tumor cell proliferation demonstrated in OSCC-P. gingivalis cocultures. Importantly, FimA + P. gingivalis strain MFI invades OSCCs, inducing inflammatory/angiogenic/oncogenic proteins stimulating OSCCs proliferation through CXCR4. Inhibition of CXCR4 abolished Pg-MFI-induced OSCCs proliferation and reduced expression of oncogenic proteins SDF-1/CXCR4, plus pAKT1-pFOXO1. Conclusively, P. gingivalis, through Mfa1 and FimA fimbriae, promotes immunosuppression and oncogenic cell proliferation, respectively, through a two-hit receptor-ligand process involving DC-SIGN+hi/CXCR4+hi, activating a pAKT+hipFOXO1+hiBIM−lowFOXP3+hi and IDO+hi- driven pathway, likely to impact the prognosis of oral cancers in patients with periodontitis.

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“…However, the correlation between HPV and OC is inconclusive mainly due to different subsites of the oral cavity being combined as a single entity in national reports [14, 15]. Finally, two independent meta-analyses correlated OC with processed meat consumption (RR = 1.91, 95% CI (1.19–3.06)) and periodontal disease (OR = 3.21, 95% CI (2.25–4.16)) [16, 17]. …”

Section: Introductionmentioning

confidence: 99%

Trends and Spatial Patterns of Oral Cancer Mortality in Ecuador, 2001–2016

Núñez-González

Delgado‐Ron

Gault

et al. 2018

International Journal of Dentistry

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The aims of this study were to describe the temporal trend of OC from 2001 to 2016 and to analyze the space and space-time clusters of high mortality due to OC in Ecuador from 2011 to 2016. Methods. The present study is a mixed ecological study; the time trends were obtained using a Joinpoint regression model, space-time scan statistics was used to identify high-risk clusters, and Global Moran I index was calculated. Results. In Ecuador, between 2001 and 2016, OC caused a total of 1,025 deaths. Crude mortality rates significantly increased, with an APC (annual percentage change) of 2.7% (p=0.009). The age-standardized mortality rate did not significantly increase (APC: 1.73%; p=0.08). The most likely cluster was detected in 2015, included 20 cantons. The second cluster included 38 cantons, in the years 2014 to 2016. The Global Moran I index for the study period showed a negative spatial autocorrelation (−0.067; p=0.37). Conclusion. Mortality due to OC in Ecuador significantly increased over the 16-year study period, the young groups being the most affected. Ecuadorian provinces present high variability in types of OC and cancer rates.

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Correlation between periodontal disease and oral cancer risk: A meta-analysis

Abstract: Our present meta-analysis indicated that periodontal disease can increase the oral cancer risk by nearly 2-fold.

Cited by 60 publications

References 0 publications

Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies

Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies

Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation

Trends and Spatial Patterns of Oral Cancer Mortality in Ecuador, 2001–2016

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