Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Induced by Cholesterol Free-High Fructose or High Cholesterol Diet.

Abstract

SummaryWe studied the coagulative and fibrinolytic activity in in trinsic or extrinsic hyperlipidemia using 4-week-old male Wistar rats. Intrinsic hyperlipidemia was induced by a cholesterol-free high-fructose diet (HFD) and extrinsic hyperlipidemia, by a high-cholesterol diet (HCD) for 14days. In intrinsic hyperlipidemic rats fed on the HFD, serum lipids were significantly increased as compared with the levels in control rats fed on a standard diet. An apparent increase in plasma fi brinogen level and coagulant factor XIII activity was also observed in HFD rats. In extrinsic hyperlipidemic rats fed on the HCD, significant increases in plasma fibrinogen level compared with that of control rats were found with the increases in serum lipids. Activities of antithrombin III and a2-plasmin inhibitor in HFD-fed rats significantly increased compared with those of control and HFD rats. There was a significant positive correlation between plasma fibrinogen and serum total cholester ol, free cholesterol, or phospholipid in diet-induced hyperlipidemia (p< 0.01). Because of the increase in coagulant XIII activity in HFD-fed rats and the increase in a2-plasmin inhibitor activity in HCD-fed rats, both diet-induced hyperlipidemic rats were shown to have enhanced coagula tive activity compared with the control rats. These results suggest that the HFD as well as the HCD causes a pre-hypercoagulative state due to the increase in plasma fibrinogen level and activities in other coagulative and fi brinolytic factors.

The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet

“…These factors can serve as important risk factors in cardiovascular disease and as independent indicators of the progression of atherosclerosis [25]. Therefore, PT and aPTT are the most widely used measures to investigate coagulation abnormalities [26].…”

Dietary Fructose: Implications for Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism

“…Recent reviews have examined the role of dietary carbohydrates in general, 25 and sugars in particular, 26 in triglyceride metabolism and cardiovascular disease risk. It is well known from studies in animals, including rodents, [27][28][29][30] dogs, 31 and nonhuman primates, 32 that feeding diets high in energy from fructose or sucrose induces hyperlipidemia. 2 It is the fructose Figure 1.…”

Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women

“…In animal studies, consumption of diets high in fructose produces obesity, insulin resistance and dyslipidemia (Bezerra et al 2000, Elliott et al 2002, Havel 2005, Martinez et al 1994, Okazaki et al 1994, Storlien et al 1993). In humans, moderate fructose consumption has no apparent health concerns (Dolan et al 2010, Rizkalla 2010), but the health consequences of fructose consumption in large amounts are less clear, particularly its effects on substrate utilization and body weight regulation.…”