Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome

Nagaraja, N.; Talwar, Pankaj; Mukherjee, Bhaskar; Chakrabarty, Barun Kumar

doi:10.4103/jhrs.jhrs_115_18

Cited by 6 publications

(1 citation statement)

References 20 publications

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“…Seven studies[ 29 30 31 32 33 34 35 ] have evaluated the impact of PPE on the live birth rate in fresh IVF cycles. Five studies have reported the impact on clinical pregnancy rate (CPR)[ 36 37 38 39 40 ] [ Table 1 ].…”

Section: P Remature P Rogesterone ...mentioning

confidence: 99%

Premature Progesterone Elevation in in vitro Fertilisation Cycles – Current Perspectives

Gurunath

2022

Journal of Human Reproductive Sciences

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The impact of premature elevation of progesterone (PPE) on the day of the trigger on pregnancy outcome in in vitro fertilisation (IVF) cycles has been a matter of contention and debate for decades. Research over the last 30 years has indicated that PPE >1.5 ng/ml is associated with declining live birth rates following fresh embryo transfer. Freeze-only approach has become a universal solution to overcome the issue of PPE. However, the topic is still mired with controversy. Few studies have not shown a negative impact on pregnancy rates. The impact of PPE on embryological parameters such as oocyte and embryo quality and ploidy is still very controversial. An important contentious issue is the choice of the threshold P value above which it is considered abnormal and a freeze-all strategy would be cost-effective. Currently, though a cutoff of >1.5 ng/ml is widely used, practices are not uniform and varying thresholds from 0.4 to 3 ng/ml are utilised. This review addresses the current understanding of PPE in IVF and the above controversies. The incidence, aetiology and source of progesterone rise, impact on endometrial receptivity, oocyte and embryo quality, impact on live birth and cumulative live birth and impact on frozen embryo transfer and donor oocyte cycles are discussed. Current controversies regarding the optimal threshold, assay performance and future directions are addressed.

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Section: P Remature P Rogesterone ...mentioning

confidence: 99%

Premature Progesterone Elevation in in vitro Fertilisation Cycles – Current Perspectives

Gurunath

2022

Journal of Human Reproductive Sciences

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Predictive Role of Progesterone Levels for IVF Outcome in Different Phases of Controlled Ovarian Stimulation for Patients With and Without Endometriosis: Expert View

Bila,

Makhadiyeva,

Dotlic

et al. 2024

Reprod. Sci.

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Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility

Zhang

Wang

et al. 2021

BMC Pregnancy Childbirth

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Background This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility. Methods We retrospectively analyzed the clinical data of 854 cycles due to fallopian tube associated infertility in vitro fertilization fresh embryo transfer. The clinical data had been collected from January 2010 to December 2018 and was divided into 7 groups depending on the progesterone level on human chorionic gonadotropin administration day. Live birth rates and observation trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups; Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone ≥ 1.25 ng/ml). We then compared the ovulation results and clinical outcomes among the 3 groups. Results There were no significant differences in age, infertility years, gonadotropin dosage, gonadotropin days, Luteinizing hormone level on human chorionic gonadotropin day, 2 pronuclear fertilization rates, clinical pregnancy rates, live birth rates, full-term birth rate, and preterm birth rates among the three groups. However body mass index (p = 0.001), basal luteinizing hormone (p = 0.034), estrogen peak (p < 0.001), number of oocytes obtained (P < 0.001) were significantly different. Conclusions Progesterone level on human chorionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0 and 1.25 ng/ml may lead to good clinical pregnancy outcomes.

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Correlation between serum progesterone level on the day of ovulation trigger during In vitro fertilization and its effect on treatment outcome

Cited by 6 publications

References 20 publications

Premature Progesterone Elevation in in vitro Fertilisation Cycles – Current Perspectives

Premature Progesterone Elevation in in vitro Fertilisation Cycles – Current Perspectives

Predictive Role of Progesterone Levels for IVF Outcome in Different Phases of Controlled Ovarian Stimulation for Patients With and Without Endometriosis: Expert View

Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility

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